Abstract
Introduction: Pantoprazole is a very suitable drug for the treatment of numerous acid-related conditions in humans and mammals. Owing to its short half-life (0.9 - 1.9 h), it is ideal for sustained release formulation.
Methods: This study was aimed at developing pantoprazole gastroretentive (GR) controlledrelease tablets and to determine the effects of this formulation and processing parameters on drug release and other critical quality attributes of directly compressed tablets produced using different matrix-forming polymers, namely, Hydroxypropyl methylcellulose (HPMC), chitosan, sodium alginate, maize starch, kappa- carrageenan, and propyl vinyl pyrrolidine PVP K- 30 when formulated into effervescent Floating Drug Delivery Systems (FDDS).
Results: The buoyancy lag time of less than 5 seconds and a total floating time of more than 12 hours for all batches is a good indication of achieved floatation for FDDS.
Conclusion: Validation processes initiated with the five batches indicated that the polymer blends had the potential for the formulation of pantoprazole FDDS and, hence, could enhance patient compliance and better treatment outcomes due to their sustained release potentials.
Keywords: Buoyancy lag time, controlled release tablets, gastro-retentive drug delivery- effervescence tablets, floating tablets, k-carrageenan, ulcer, proton pump inhibitors, pantoprazole.
Call for Papers in Thematic Issues
Gut microbiota in gastrointestinal and non-gastrointestinal diseases
The complex interplay between gut microbiota and human health has become a focal point in medical research. For this reason, the aim of this special issue is to explore the multifaceted role of gut microbiota in both gastrointestinal and non-gastrointestinal diseases. Regarding the dynamic symbiosis between the microbial communities residing ...read more
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