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Review Article

miR-26a是人类疾病诊断和预后中具有巨大潜力的关键治疗靶点

卷 31, 期 18, 2024

发表于: 09 January, 2024

页: [2550 - 2570] 页: 21

弟呕挨: 10.2174/0109298673271808231116075056

价格: $65

摘要

MicroRNA-26a (miR-26a)属于非编码调节性小分子RNA，是抑制基因表达的基础转录后调控因子，在人类疾病的各个过程中发挥重要作用，如抑郁症、肾缺血再灌注损伤、肝损伤和一些难治性癌症。在这篇综述中，我们阐述了miR-26a的研究结果，重点介绍了其在动物模型或体外细胞培养中的功能，以模拟临床上最常见的人类疾病。此外，我们还阐明了miR-26a在增强抗肿瘤药物抗肿瘤活性中的潜在机制。重要的是，miR-26a的失调与许多慢性和恶性疾病有关，特别是与大脑中的神经系统疾病如抑郁症和神经退行性疾病以及癌症如甲状腺乳头状癌、肝细胞癌等有关。由此可见，miR-26a极有可能成为治疗神经系统疾病和癌症的潜在治疗靶点。尽管在过去的几十年里，mirna的研究取得了很大的进展，但仍有许多有待发现，特别是关于它们在人类复杂疾病中的潜在机制和作用。因此，我们分析了miR-26a在慢性和恶性疾病中的作用，并讨论了miR-26a的失调及其在这些疾病的发生和发病机制中的功能作用，这将有助于在不久的将来了解其作为诊断和治疗疾病的新生物标志物的机制。

关键词: miR-26a，生物标志物，人类疾病，表达水平，靶基因，心脏纤维化。

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