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摘要
范围:非酒精性脂肪性肝病(NAFLD)在全球范围内的患病率很高,而且还在不断增长。线粒体是调节细胞能量稳态的基础。然而,在这种能量过载的情况下,线粒体控制机制可能会被超越。受损的线粒体会恶化 NAFLD 的进展。饮食和生活方式的改变是 NAFLD 预防和治疗的主要建议。一些多酚在不同的 NAFLD 和肥胖模型中改善了线粒体功能。 目的:本研究旨在讨论多酚作为靶向线粒体的非药物方法在预防和治疗 NAFLD 中的潜在作用,分析多酚化学结构的影响、局限性和临床预测。 方法:考虑了体内和体外 NAFLD 模型。使用以下关键词进行研究搜索:非酒精性脂肪肝、肝脂肪变性、线粒体、线粒体活性、线粒体动力学、线粒体功能障碍、线粒体形态、线粒体嵴、融合、裂变、多酚、类黄酮、花青素和/或生物活性化合物。 结论:多酚是一类具有多样性的生物活性分子,其生物活性作用很大程度上取决于其化学结构。这些生物活性化合物可以提供一种有趣的非药理学方法来预防和治疗 NAFLD,调节线粒体动力学和功能。然而,线粒体在接受 NAFLD 治疗的受试者中的作用尚未完全阐明。研究时应说明这些化合物的剂量和生物利用度。
关键词: 生物活性化合物,肝脂肪变性,线粒体功能障碍,肥胖,酚类化合物。
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