摘要
锌 (Zn2+)是体内的重要微量元素之一。对大量的酶和转录因子蛋白的正常功能是必须的。然而,细胞外液可能包含微摩尔的Zn2+,但是胞内Zn2+ 浓度总体上维持在亚纳摩尔浓度;这种跨过细胞膜的大变化主要由Zn2+运输系统的Zn2+挤压引起。有趣地是,系统调查揭示Zn2+可能调节部分活性,先前一直认为依赖于钙(Ca2+)。,这也得到了新发现的支持,一些Ca2+可渗透通道如电压依赖性钙离子通道(VDCCs)、天门冬氨酸(MMDA)、氨甲基磷酸受体(AMPA-Rs) 对Zn2+也有渗透性。因此,Zn2+在生理和病理的进展方面的重要性现在得到广泛研究。本综述,我们描述了细胞内Zn2+动力学和Zn2+调节的生理病理方面的Zn2+渗透膜分子,尤其是Zn2+渗透离子通道。
关键词: 钙,荧光成像,离子通道,锌
Current Medicinal Chemistry
Title:Zinc-Permeable Ion Channels: Effects on Intracellular Zinc Dynamics and Potential Physiological/Pathophysiological Significance
Volume: 22 Issue: 10
Author(s): Koichi Inoue, Zaven O'Bryant and Zhi-Gang Xiong
Affiliation:
关键词: 钙,荧光成像,离子通道,锌
摘要: Zinc (Zn2+) is one of the most important trace metals in the body. It is necessary for the normal function of a large number of protein s including enzymes and transcription factors. While extracellular fluid may contain up to micromolar Zn2+, intracellular Zn2+ concentration is generally maintained at a subnanomolar level; this steep gradient across the cell membrane is primarily attributable to Zn2+ extrusion by Zn2+ transporting systems. Interestingly, systematic investigation has revealed that activities, previously believed to be dependent on calcium (Ca2+), may be partially mediated by Zn2+. This is also supported by new findings that some Ca2+-permeable channels such as voltage-dependent calcium channels (VDCCs), N-methyl-D-aspartate receptors (NMDA), and amino-3- hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPA-Rs) are also permeable to Zn2+. Thus, the importance of Zn2+ in physiological and pathophysiological processes is now more widely appreciated. In this review, we describe Zn2+- permeable membrane molecules, especially Zn2+-permeable ion channels, in intracellular Zn2+dynamics and Zn2+ mediated physiology/pathophysiology.
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Koichi Inoue, Zaven O'Bryant and Zhi-Gang Xiong , Zinc-Permeable Ion Channels: Effects on Intracellular Zinc Dynamics and Potential Physiological/Pathophysiological Significance, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150209153750
DOI https://dx.doi.org/10.2174/0929867322666150209153750 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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