摘要
菌落刺激因子(G-CSF) 具有多模型的神经保护作用,并且来自多种转导研究累积的临床数据统计上证实了G-CSF作为一种缺血性中风治疗剂的选择的功效。G-CSF激活了抗凋亡、抗氧化和抗炎的信号通路,并且促进了血管生成和神经再生。本文中,我们总结了在神经保护作用中G-CSF的作用和由G-CSF调节的相应的信号转导通路,并且讨论了其作为一种治疗中风的新药的潜力。
关键词: 菌落刺激因子,神经保护,中风,治疗
Current Medicinal Chemistry
Title:New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients
Volume: 22 Issue: 10
Author(s): Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles and John H. Zhang
Affiliation:
关键词: 菌落刺激因子,神经保护,中风,治疗
摘要: Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
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Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles and John H. Zhang , New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150209153606
DOI https://dx.doi.org/10.2174/0929867322666150209153606 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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