摘要
早产儿的新生儿脑缺血(NBH)是早产造成的不幸后果。并发症的结果是分流装置依赖性和长期结构性变化如出血后脑积水、脑室周围白质软化、胶质增生和神经机能障碍。许多动物模型用来研究这种情况,并且许多基本机制、病因和后果的影响开始被了解。NBH是一种重要的临床状况,其治疗也许会潜在避开分流器并发症和改善机能恢复(大脑麻痹和认知障碍)。出血后脑积水影响易受到伤害的新生儿人群,在针对此分子机制的背景下,本综述突出了新生儿血管-神经网络的病理生理发现。
关键词: 大脑麻痹,实验性的,胚矩阵出血,脑积水,智力落后,新生大鼠,神经机能障碍
Current Medicinal Chemistry
Title:Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Volume: 22 Issue: 10
Author(s): Tim Lekic, Damon Klebe, Roy Poblete, Paul R. Krafft, William B. Rolland, Jiping Tang and John H. Zhang
Affiliation:
关键词: 大脑麻痹,实验性的,胚矩阵出血,脑积水,智力落后,新生大鼠,神经机能障碍
摘要: Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.
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Cite this article as:
Tim Lekic, Damon Klebe, Roy Poblete, Paul R. Krafft, William B. Rolland, Jiping Tang and John H. Zhang , Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150114152421
DOI https://dx.doi.org/10.2174/0929867322666150114152421 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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