摘要
神经退行性疾病,如阿尔茨海默病(AD)和帕金森病(PD)的特征为神经元的进行性丧失和随后的认知减退。他们主要发生于年龄较大的人群。由于平均寿命的增加,社会上遭受这些疾病的痛苦继续变得更沉重和突出。尽管有大量的研究,虽然这些疾病的病理生理机制已经被归因于脑内氧化、炎症和凋亡损伤,然而这些疾病的准确病因仍然未知。并且,目前没有对抗神经退变性变化的有望治疗剂。梓醇,主要存在于开花植物地黄根部的一种环烯醚萜葡萄糖苷类化合物,显示其有抗氧化作用、抗炎、抗细胞凋亡和其它神经保护作用的性质,对体内外模型的缺氧/缺血性损伤、AD和PD起到神经保护作用。因此它也许对治疗缺氧/缺血性损伤或神经退行性疾病代表一种潜在治疗剂。基于我们的研究及其它文献上的报道,在此我们全面综述了梓醇抗病理状况的神经保护作用,尤其是其在神经变性状态和涉及的潜在机制中的作用。
关键词: 梓醇,神经退行性疾病,神经保护,氧化应激,炎症,线粒体,核因子-κB,神经营养因子
Current Medicinal Chemistry
Title:Catalpol: A Potential Therapeutic for Neurodegenerative Diseases
Volume: 22 Issue: 10
Author(s): B. Jiang, R.F. Shen, J. Bi, X.S. Tian, T Hinchliffe and Y. Xia
Affiliation:
关键词: 梓醇,神经退行性疾病,神经保护,氧化应激,炎症,线粒体,核因子-κB,神经营养因子
摘要: Neurodegenerative disorders, e.g., Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by the progressive loss of neurons and subsequent cognitive decline. They are mainly found in older populations. Due to increasing life expectancies, the toll inflicted upon society by these disorders continues to become heavier and more prominent. Despite extensive research, however, the exact etiology of these disorders is still unknown, though the pathophysiological mechanisms have been attributed to oxidative, inflammatory and apoptotic injury in the brain. Moreover, there is currently no promising therapeutic agent against these neurodegenerative changes. Catalpol, an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models. It may therefore represent a potential therapeutical agent for the treatment of hypoxic/ischemic injury and neurodegenerative diseases. Based on our studies and those of others in the literature, here we comprehensively review the role of Catalpol in neuroprotection against pathological conditions, especially in neurodegenerative states and the potential mechanisms involved.
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Cite this article as:
B. Jiang, R.F. Shen, J. Bi, X.S. Tian, T Hinchliffe and Y. Xia , Catalpol: A Potential Therapeutic for Neurodegenerative Diseases, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150114151720
DOI https://dx.doi.org/10.2174/0929867322666150114151720 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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