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Current Pharmaceutical Design

Volume 25, 46 Issues, 2019
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 24

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Number 46



Perspective   Open Access



Editorial   Open Access

Mineralocorticoid Receptor Antagonists in Cardiovascular Medicine: Looking for the Forest Among the Trees

, 24(46): 5489 - 5490

Konstantinos V. Stavropoulos, Konstantinos P. Imprialos, Michael Doumas and Charles J. Faselis


DOI: 10.2174/138161282446190426120024


Review Article

The Mechanisms of Actions of Aldosterone and its Antagonists in Cardiovascular Disease

, 24(46): 5491 - 5499

Panteleimon Pantelidis, Michail Sideris, Margus Viigimaa, Konstantinos Avranas, Pavlos Deligkaris, Ioanna Zografou and Dragan Lovic*


DOI: 10.2174/1381612825666190215100502


Review Article

Mineralocorticoid Receptor Antagonists in Essential and Resistant Hypertension

, 24(46): 5500 - 5507

Konstantinos P. Imprialos, Sofia Bouloukou, Georgios Kerpiniotis, Alexandra Katsimardou, Dimitrios Patoulias, Constantinos Bakogiannis and Charles Faselis*


DOI: 10.2174/1381612825666190306163310


Review Article

Mineralocorticoid Receptor Antagonists in Primary Aldosteronism

, 24(46): 5508 - 5516

Konstantinos Stavropoulos, Christodoulos Papadopoulos, Konstantinos Koutsampasopoulos, Georgios Lales, Christos Mitas and Michael Doumas*


DOI: 10.2174/1381612825666190311130138


Review Article

The Role of Mineralocorticoid Receptor Antagonists in Heart Failure with Reduced Ejection Fraction

, 24(46): 5517 - 5524

Vasilios Papademetriou*, Maria Toumpourleka, Konstantinos P. Imprialos, Sofia Alataki, Alexandros Manafis and Konstantinos Stavropoulos


DOI: 10.2174/1381612825666190219141326


Review Article



Review Article

Mineralocorticoid Receptor Antagonists for Nephroprotection: Current Evidence and Future Perspectives

, 24(46): 5528 - 5536

Pantelis A. Sarafidis*, Evangelos Memmos, Maria-Eleni Alexandrou and Aikaterini Papagianni


DOI: 10.2174/1381612825666190306162658


Current Pharmaceutical Design, Volume 25 (2019) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 25 (2019) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 25 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 25 (2019) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 25 (2019) - Number 2


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 25 (2019) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



The Function of RAS Mutation in Cancer and Advances in its Drug Research


Shijie Chen, Fengyang Li , Dan Xu, Kai Hou, Weirong Fang and Yunman Li *


View Abstract View on PubMed


3D Printing Technology: A New Milestone in the Development of Pharmaceuticals


Anish Chandekar, Dinesh K. Mishra*, Sanjay Sharma, Gaurav K. Saraogi, Umesh Gupta and Gaurav Gupta


View Abstract


Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments


Elisa Magli, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Irene Saccone, Vincenzo Santagada, Giuseppe Caliendo* and Beatrice Severino


View Abstract View on PubMed



Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment


Allison B. Reiss*, Andrew Silverman, Muhammed Khalfan, Nicholas A. Vernice, Lora J. Kasselman, Steven E. Carsons and Joshua De Leon


View Abstract



Preventive Role of Resveratrol Against Inflammatory Cytokines and Related Diseases


Tanzir Rafe, Parvez Ahmed Shawon, Liyad Salem, Nafij Imtiyaj Chowdhury, Farjana Kabir, Shah Mehedi Bin Zahur, Rowshon Akther, Humaira Binte Noor, Md Mohabbulla Mohib and Md. Abu Taher Sagor*


View Abstract View on PubMed


Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer


Chang Gao, Ya-Nan Peng, Hai-Zhou Wang, Shi-Lin Fang, Meng Zhang, Qiu Zhao and Jing Liu*


View Abstract


Abstracts Ahead of Print

Recent Advances in the Use of Algal Polysaccharides for Skin Wound Healing


Suneel Kumar, Ileana Marrero-Berrios, Maciej Kabat and Francois Berthiaume*


View Abstract


Applications of Magnetic Liposomes in Cancer Therapies


Anilkumar T. S, K.T. Shalumon and Jyh-Ping Chen*


View Abstract





Structure and bioactivities of porphyrans and oligoporphyrans


Lihua Geng, Jing Wang, Zhongshan Zhang, Yang Yue and Quanbin Zhang*


View Abstract


Carrageenan: A Wonder Polymer from Marine Algae for Potential Drug Delivery Applications


Dilshad Qureshia, Suraj Kumar Nayaka, Samarandra Majib, Doman Kim, Indranil Banerjeea and Kunal Pala*


View Abstract


Alginate nanoparticles for drug delivery and targeting


Patr Severino, Classius F da Silva, Luciana N. Andrade, D. de Lima Oliveira, J. Campos and Eliana B. Souto*


View Abstract


Applications of algal polysaccharides and derivatives in therapeutic and agricultural fields


Bouissil S., Pierre G., El Alaoui-Talibi Z., Michaud P., El Modafar C. and Delattre C.*


View Abstract


Sulfated polysaccharides from macroalgae for bone tissue regeneration


Jayachandran Venkatesan*, Sukumaran Anil, Sneha Rao, Se-Kwon Kim and Ira Bhatnagar


View Abstract


Published Contents

Editor's Choice



Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems

, 2018; 24(43): 5147 - 5163

Nagarani Thotakura, Lokesh Kaushik, Vipin Kumar, Simran Preet and Penke Vijaya Babu*


DOI: 10.2174/1381612825666190206211458



Role of Polymers in 3D Printing Technology for Drug Delivery - An Overview

, 2018; 24(42): 4979 - 4990

Ankit Jain, Kuldeep K. Bansal*, Ankita Tiwari, Ari Rosling and Jessica M. Rosenholm*


DOI: 10.2174/1381612825666181226160040





The Role of TGF-β Signaling Regulatory MicroRNAs in the Pathogenesis of Colorectal Cancer

, 2018; 24(39): 4611 - 4618

Reyhaneh Moradi-Marjaneh, Majid Khazaei, Gordon A. Ferns and Seyed H. Aghaee-Bakhtiari*


DOI: 10.2174/1381612825666190110150705



Rivaroxaban versus Clopidogrel for Peripheral Artery Disease: A Clinico-Economic Approach of the COMPASS Trial

, 2018; 24(38): 4516 - 4517

Diamantis I. Tsilimigras, Demetrios Moris*, Georgios Karaolanis, Stavros K. Kakkos, Konstantinos Filis and Fragiska Sigala


DOI: 10.2174/1381612825666190101100832



Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease

, 2018; 24(37): 4436 - 4444

Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Maryam Ghandehari, Seyed Mohammad Reza Parizadeh, Seyed Mahdi Hassanian, Majid Rezayi, Majid Ghayour-Mobarhan, Gordon A. Ferns and Amir Avan*


DOI: 10.2174/1381612825666181219162655



Potential of Natural-Based Anticancer Compounds for P-Glycoprotein Inhibition

, 2018; 24(36): 4334 - 4354

Jelena Dinić, Ana Podolski-Renić, Marko Jeremić and Milica Pešić*


DOI: 10.2174/1381612825666190112164211



Open Access Articles



Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy

, 2018; 24(41): 4911 - 4920

Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*





Novel Data on the Prevalence, Identification, Scouting, and Treatment of Familial Hypercholesterolaemia

, 2018; 24(31): 3597 - 3598

Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos and Vasilios G. Athyros





Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24(26): 3143 - 3151

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky




Novel Technologies for Dipeptide Drugs Design and their Implantation

, 2018; 24(26): 3020 - 3027

Tatiana A. Gudasheva*, Rita U. Ostrovskaya and Sergey B. Seredenin




Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example

, 2018; 24(22): 2530 - 2540

Jian Han, Yonghong Xia, Lejun Lin, Zuoguang Zhang, Hui Tian and Kefeng Li*





Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production

, 2018; 24(18): 2012 - 2022

Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*




Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24(13): 1366 - 1376

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*




Development of Peptide Vaccines in Dengue

, 2018; 24(11): 1157 - 1173

Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*





Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2018; 24(5): 576 - 594

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo





Most Cited Articles

Review Article

Polyphenols: Potential use in the prevention and treatment of cardiovascular diseases

, 1 January 2018; 24(2): 239-258.

Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo F.G. Cicero, Giuseppe Lippi, Manfredi Rizzo*, Peter P. Toth and Maciej Banach


DOI: 10.2174/1381612824666180130112652


Review Article

Curcumin: A natural pan-HDAC inhibitor in cancer

, 1 January 2018; 24(2): 123-129.

Sara Saffar Soflaei, Amir Abbas Momtazi-Borojeni, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar*


DOI: 10.2174/1381612823666171114165051


Review Article

Recent findings in molecular basis of inflammation and anti-inflammatory plants

, 2018; 24(14): 1551-1562.

Sedigheh Kazemi, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei*


DOI: 10.2174/1381612824666180403122003


Review Article

Colchicine pharmacokinetics and mechanism of action

, 2018; 24(6): 659-663.

Christos Angelidis*, Zoi Kotsialou, Charalampos Kossyvakis, Agathi-Rosa Vrettou, Achilleas Zacharoulis, Fotios Kolokathis, Vasilios Kekeris and Georgios Giannopoulos


DOI: 10.2174/1381612824666180123110042


Review Article

Rapid-acting antidepressants

, 2018; 24(22): 2556-2563.

Jeffrey M. Witkin*, Daniel E. Knutson, Gabriel J. Rodriguez and Samuel Shi


DOI: 10.2174/1381612824666180730104707


Review Article

Signaling pathways in inflammation and anti-inflammatory therapies

, 2018; 24(14): 1449-1484.

Yiu To Yeung, Faisal Aziz, Angelica Guerrero-Castilla and Sandro Arguelles*


DOI: 10.2174/1381612824666180327165604


Research Article

PNitro-Tyr-PseAAC: Predict nitrotyrosine sites in proteins by incorporating five features into Chou’s general PseAAC

, 2018; 24(34): 4034-4043.

Ahmad W. Ghauri, Yaser D. Khan, Nouman Rasool, Sher A. Khan* and Kuo-Chen Chou


DOI: 10.2174/1381612825666181127101039


Research Article

Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity

, 2018; 24(5): 576-594.

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo


DOI: 10.2174/1381612823666170711112510


Review Article

Potential use of nanomedicine for the anti-inflammatory treatment of neurodegenerative diseases

, 2018; 24(14): 1589-1616.

Maria Dolores Cayero-Otero, Ana M. Espinosa-Oliva*, Antonio J. Herrera, Irene Garcia-Dominguez, Mercedes Fernandez-Arevalo, Lucia Martin-Banderas and Rocio M. de Pablos


DOI: 10.2174/1381612824666180403113015


Review Article

Statins and contrast-induced nephropathy: A systematic review and meta-analysis

, 2018; 23(46): 7141-7148.

Alexandros Briasoulis*, Mohan Pala , Tesfaye Telila , Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi , Evangelos Oikonomou and Dimitris Tousoulis


DOI: 10.2174/1381612823666170913170527


Review Article

Cytoprotective polyphenols against chronological skin aging and cutaneous photodamage

, 1 January 2018; 24(2): 99-105.

Sergio Davinelli*, Juan Carlos Bertoglio, Ascanio Polimeni and Giovanni Scapagnini


DOI: 10.2174/1381612823666171109102426


Review Article

Curcumin as an adjunct therapy and microRNA modulator in breast cancer

, 1 January 2018; 24(2): 171-177.

Saeed Norouzi, Muhammed Majeed, Matteo Pirro, Daniele Generali and Amirhossein Sahebkar*


DOI: 10.2174/1381612824666171129203506


Review Article

Statins and oxidative stress in the cardiovascular system

, 2018; 23(46): 171-177.

Saeed Norouzi, Muhammed Majeed, Matteo Pirro, Daniele Generali and Amirhossein Sahebkar*


DOI: 10.2174/138161282366617092613033


Review Article

Antibacterial coatings based on chitosan for pharmaceutical and biomedical applications

, 2018; 24(8): 866-885.

Juliana Miguel Vaz, Daniele Pezzoli, Pascale Chevallier, Clayton Souza Campelo, Gabriele Candiani and Diego Mantovani*


DOI: 10.2174/1381612824666180219143900


Review Article

Cell stress signaling cascades regulating cell fate

, 2018; 24(27): 3176-3183.

Rohit Gundamaraju*, Ravichandra Vemuri, Wai Chin Chong, Dominic P. Geraghty and Rajaraman Eri


DOI: 10.2174/1381612824666180711122753



Most Accessed Articles

Advances in Binding Free Energies Calculations: QM/MM-Based Free Energy Perturbation Method for Drug Design

, 2013; 19(26): 4674-4686.

R.S. Rathore, M. Sumakanth, M. Siva Reddy, P. Reddanna, Allam Appa Rao, Mark D. Erion and M.R. Reddy


DOI: 10.2174/1381612811319260002


Recent Advances in Cancer Therapy: An Overview

, 2010; 16(1): 3-10.

A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals and G. Capella


DOI: 10.2174/138161210789941847


Reversal of Novel Anticoagulants in Emergent Surgery and Trauma: A Comprehensive Review and Proposed Management Algorithm

, 2018; 24(38): 4540-4553.

Leonidas Palaiodimos*, Jeremy Miles, Damianos G. Kokkinidis, Christos Barkolias, Anil K. Jonnalagadda, Dimitrios Papaconstantinou, Maximos Frountzas, Evangelos P. Misiakos and Dimitrios Schizas


DOI: 10.2174/1381612825666181226150629



Computer-aided Drug Design and Drug Pharmacokinetic Prediction: A Mini-review

, 2018; 24(26): 3014-3019.

Jamshid Tabeshpour, Amirhossein Sahebkar*, Mohammad Reza Zirak, Majid Zeinali, Mahmoud Hashemzaei, Sajed Rakhshani and Saleh Rakhshani*


DOI: 10.2174/1381612824666180903123423




Association of SLCO1B1 Polymorphisms and Atorvastatin Safety and Efficacy: A Meta-analysis

, 2018; 24(34): 4044-4050.

Yaming Du, Sizheng Wang, Zhangyong Chen, Shusen Sun, Zhigang Zhao* and Xingang Li*


DOI: 10.2174/1381612825666181219163534


The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer

, 2018; 24(32): 3767-3777.

Ashfaq Ur Rehman, Mueed Ur Rahman, Muhammad T. Khan, Shah Saud, Hao Liu, Dong Song, Pinky Sultana, Abdul Wadood and Hai-Feng Chen*


DOI: 10.2174/1381612824666181106100837



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