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Current Pharmaceutical Design

Volume 27, 46 Issues, 2021
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

,

Volume 27

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Number 3





Review Article





Review Article

Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

, 27(3): 357 - 366

Md. Sahab Uddin*, Md. Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A. Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez and Ghulam Md Ashraf*


DOI: 10.2174/1381612826666200531151004


Review Article

Targeting Xanthine Oxidase by Natural Products as a Therapeutic Approach for Mental Disorders

, 27(3): 367 - 382

Miquel Martorell*, Xavier Lucas, Pedro Alarcón-Zapata, Xavier Capó, Maria Magdalena Quetglas-Llabrés, Silvia Tejada and Antoni Sureda


DOI: 10.2174/1381612826666200621165839


Review Article

Phytosterols: Targeting Neuroinflammation in Neurodegeneration

, 27(3): 383 - 401

Raju Dash, Sarmistha Mitra, Md. Chayan Ali, Diyah Fatimah Oktaviani, Md. Abdul Hannan, Sung Min Choi and Il Soo Moon*


DOI: 10.2174/1381612826666200628022812


Review Article

Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease

, 27(3): 402 - 414

Md. Sahab Uddin*, Sharifa Hasana, Jamil Ahmad, Md. Farhad Hossain, Md. Mosiqur Rahman, Tapan Behl, Abdur Rauf, Ausaf Ahmad, Abdul Hafeez, Asma Perveen and Ghulam Md Ashraf*


DOI: 10.2174/1381612826666201118092422


Review Article (Mini-Review)

Prospects for miR-21 as a Target in the Treatment of Lung Diseases

, 27(3): 415 - 422

Yan Ding, Yapeng Hou, Yanhong Liu, Xiaoyong Xie, Yong Cui and Hongguang Nie*


DOI: 10.2174/1381612826999200820160608


Current Pharmaceutical Design, Volume 27 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print




Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections


Arquimedes Gasparotto Junior*, Sara Emília Lima Tolouei, Francislaine Aparecida dos Reis Lívero, Francielli Gasparotto, Thaise Boeing and Priscila de Souza


DOI: 10.2174/1381612827666210114150607
View Abstract View on PubMed


Impact of Sex on Office White Coat effect Tail: A Review


Xavier Humbert*, Sophie Fedrizzi, Agnès Hofferer, Mathieu Bansard, Anne-Laure Huet, Christiane Bedier, Andry Rabiaza, Jeanne Le Bas, François LE Bas, Joachim Alexandre and Paolo Emilio Puddu


DOI: 10.2174/1381612827999210112204306
View Abstract View on PubMed



Pregnancy and Viral Hepatitis: Current Concepts


Nikoletta Maria Tagkou, Georgios Kondylis and Evangelos Cholongitas*


DOI: 10.2174/1381612826666201210113841
View Abstract View on PubMed



Cardio-protective Effects of Glucagon-like Peptide-1 Receptor Agonists: An Overview of Systematic Reviews and Publication Overlap


Stefanos Zafeiropoulos, Areti Pagiantza, Ioannis Doundoulakis, Nikolaos Stalikas, Ioannis Farmakis, Athanasios Samaras, Christina Antza and George Giannakoulas*


DOI: 10.2174/1381612827666210119103153
View Abstract View on PubMed


Risk Prediction Models and Scores in Hypertrophic Cardiomyopathy


Thomas D. Gossios*, Konstantinos Savvatis, Thomas Zegkos, Despina Parcharidou, Haralambos I Karvounis and Georgios K Efthimiadis


DOI: 10.2174/1381612827666210125121115
View Abstract


Abstracts Ahead of Print

Identification of butyrylcholinesterase and monoamine oxidase B targeted ligands and their putative application in Alzheimer’s treatment: A computational strategy


Nasimudeen R Jabir, Md Tabish Rehman, Shams Tabrez*, Raed F. Alserihi, Mohamed F AlAjmi, Mohd Shahnawaz Khan, Fohad Mabood Husain and Bakrudeen Ali Ahmed*


DOI: 10.2174/1381612827666210226123240
View Abstract



Recent updates on current and upcoming biomarkers for cardiovascular diseases


Ashif Iqubal, Aamir Khan, Adeeba laeeq, Kabil Malhotra, Mohd. Asif Ansari and Syed Ehtaishamul Haque*


DOI: 10.2174/1381612827666210224143047
View Abstract


COVID-19: Epidemiology, Pathology, Diagnosis, Treatment, and Impact


Saimon Shahriar, Md. Sohel Rana, Md. Sabbir Hossain, Ariful Karim, Tasneem Nayla Mredula, Nadia Nourin, Md. Sahab Uddin* and Md. Shah Amran*


DOI: 10.2174/1381612827666210224142446
View Abstract


Complex Treatment and Prosthetic Rehabilitation of an Acquired Maxillofacial Defect with Tumor Invasion: Case Report


Li Jiajing, Ekaterina V. Kochurova, Narasimha M Beeraka, Natalya V. Lapina, Chang Weilong, Dmitrii M. Belousov, Elizaveta V. Mikhaylenko, Vladimir N. Nikolenko, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland, Marco Avila-Rodríguez and Gjumrakch Aliev*


DOI: 10.2174/1381612827666210224141559
View Abstract


Statistically Designed Extraction of Herbs Using Ultrasound Waves: A Review


Ashwani Arya, Rubal Chahal, Arun Nanda, Deepak Kaushik, May Bin- Jumah, Md Habibur Rahman, Mohamed M Abdel-Daim* and Vineet Mittal*


DOI: 10.2174/1381612827666210222114441
View Abstract






Published Contents

Editor's Choice

Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

, 2021; 27(3): 357 - 366

Md. Sahab Uddin*, Md. Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A. Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez and Ghulam Md Ashraf*


DOI: 10.2174/1381612826666200531151004



Do Mitochondrial DNA Mutations Play a Key Role in the Chronification of Sterile Inflammation? Special Focus on Atherosclerosis

, 2021; 27(2): 276 - 292

Alexander N. Orekhov*, Elena V. Gerasimova, Vasily N. Sukhorukov, Anastasia V. Poznyak* and Nikita G. Nikiforov


DOI: 10.2174/1381612826666201012164330



Repurposing Drugs for the Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19)

, 2021; 27(1): 115 - 126

Evellyn Claudia Wietzikoski Lovato, Lorena Neris Barboza, Samantha Wietzikoski, Amanda Nascimento Vasques de Souza, Pablo Alvarez Auth, Arquimedes Gasparotto Junior and Francislaine Aparecida dos Reis Lívero*


DOI: 10.2174/1381612826666200707121636



Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

, 2021; 27(1): 2 - 14

Joel Hardwick, Jack Taylor, Meenu Mehta, Saurabh Satija, Keshav R. Paudel, Philip M. Hansbro, Dinesh K. Chellappan, Mary Bebawy* and Kamal Dua*


DOI: 10.2174/1381612826666200728151610



Therapeutic Options for Mucopolysaccharidosis II (Hunter Disease)

, 2020; 26(40): 5100 - 5109

Francyne Kubaski, Filippo Vairo, Guilherme Baldo, Fabiano de Oliveira Poswar, Amauri Dalla Corte and Roberto Giugliani*


DOI: 10.2174/1381612826666200724161504




Catechins as Model Bioactive Compounds for Biomedical Applications

, 2020; 26(33): 4032 - 4047

Adriana N. dos Santos, Tatiana R. de L. Nascimento, Brenna L. C. Gondim, Marilia M. A. C. Velo, Renaly I. de A. Rêgo, José R. do C. Neto, Juliana R. Machado, Marcos V. da Silva, Helvia W. C. de Araújo, Maria G. Fonseca and Lúcio R. C. Castellano*


DOI: 10.2174/1381612826666200603124418




Precision Medicine Approach in Prostate Cancer

, 2020; 26(31): 3783 - 3798

Majid Assadi, Narges Jokar, Mojtaba Ghasemi, Iraj Nabipour, Ali Gholamrezanezhad and Hojjat Ahmadzadehfar*


DOI: 10.2174/1381612826666200218104921




Open Access Articles


Treatment of Anderson-Fabry Disease

, 2020; 26(40): 5089 - 5099

Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto




Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

, 2020; 26(36): 4569 - 4579

Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*




A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats

, 2020; 26(31): 3884 - 3894

Branka Petković*, Srđan Kesić, Slavica Ristić, Željko Pavković, Jelena Podgorac, Gordana Stojadinović and Vesna Pešić





γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis

, 2020; 26(25): 3026 - 3038

Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M. Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga*, Péter Révész, István Szanyi, Kázmér Karádi and Gábor Gerber




Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

, 2020; 26(25): 3015 - 3025

Beáta Kerémi, Katalin Márta, Kornélia Farkas, László M. Czumbel, Barbara Tóth, Zsolt Szakács, Dezső Csupor, József Czimmer, Zoltán Rumbus, Péter Révész, Adrienn Németh, Gábor Gerber, Péter Hegyi and Gábor Varga*




Artemia species: An Important Tool to Screen General Toxicity Samples

, 2020; 26(24): 2892 - 2908

Epole Ntungwe N, Eva M. Domínguez-Martín, Amilcar Roberto, Joana Tavares, Vera M. S. Isca, Paula Pereira, Maria-João Cebola and Patrícia Rijo*




Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

, 2020; 26(16): 1917 - 1928

Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*






Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

, 2020; 26(13): 1417 - 1427

Carolin J. Curtaz, Constanze Schmitt, Kinga G. Blecharz-Lang, Norbert Roewer, Achim Wöckel and Malgorzata Burek*




A Chronological Review of Potential Disease-Modifying Therapeutic Strategies for Alzheimer's Disease

, 2020; 26(12): 1286 - 1299

Miren Ettcheto, Oriol Busquets, Triana Espinosa-Jiménez, Ester Verdaguer , Carme Auladell and Antoni Camins*





Role of microRNA and Long Non-Coding RNA in Hepatocellular Carcinoma

, 2020; 26(4): 415 - 428

Meenakshi Gupta, Kumari Chandan and Maryam Sarwat*





Most Cited Articles

Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541


Review Article

Exploring the multifunctional neuroprotective promise of rasagiline derivatives for multi-dysfunctional Alzheimer’s disease

, 2020; 26(37): 4690-4698.

Md. Sahab Uddin*, Md. Tanvir Kabir, Md. Habibur Rahman, Md. Abdul Alim, Md. Motiar Rahman, Anurag Khatkar, Abdullah Al Mamun, Abdur Rauf, Bijo Mathew and Ghulam Md. Ashraf


DOI: 10.2174/1381612826666200406075044


Review Article

Polymer-lipid hybrid nanoparticles: A next-generation nanocarrier for targeted treatment of solid tumors

, 2020; 26(11): 1206-1215.

Md. Rizwanullah, Meraj Alam, Harshita, Showkat R. Mir, Mohd. M.A. Rizvi and Saima Amin*


DOI: 10.2174/1381612826666200116150426


Review Article

Lipid-based nanosystem as intelligent carriers for versatile drug delivery applications

, 2020; 26(11): 1167-1180.

Harshita, Md. Abul Barkat, Sabya S. Das, Faheem H. Pottoo, Sarwar Beg and Ziyaur Rahman*


DOI: 10.2174/1381612826666200206094529


Review Article

Nanomedicines in diagnosis and treatment of cancer: An update

, 2020; 26(11): 1216-1231.

Nafis Haider, Sana Fatima, Murtada Tahar, Md. Rizwanullah, Jamia Firdous, Rafeeque Ahmad , Faizan Mazhar and Mohammad A. Khan*


DOI: 10.2174/1381612826666200318170716


Review Article

Current nanoparticle approaches in nose to brain drug delivery and anticancer therapy-a review

, 2020; 26(11): 1128-1137.

Mohammad A. Ansari, Ill-Min Chung, Govindasamy Rajakumar, Mohammad A. Alzohairy, Mohammad N. Alomary, Muthu Thiruvengadam*, Faheem H. Pottoo and Niyaz Ahmad


DOI: 10.2174/1381612826666200116153912


Review Article

Liposomes: Novel drug delivery approach for targeting Parkinson’s disease

, 2020; 26(37): 4721-4737.

Bhumika Kumar, Mukesh Pandey, Faheem H. Pottoo, Faizana Fayaz, Anjali Sharma and P.K. Sahoo*


DOI: 10.2174/1381612826666200128145124


Review Article

Surface-engineered cancer nanomedicine: Rational design and recent progress

, 2020; 26(11): 1181-1190.

Javed Ahmad*, Ameeduzzafar, Mohammad Z. Ahmad and Habban Akhter


DOI: 10.2174/1381612826666200214110645


Review Article

Applications of nanocarriers as drug delivery vehicles for active phytoconstituents

, 2020; 26(36): 4580-4590.

Phui Qi Ng, Laura Soon Cheau Ling, Jestin Chellian, Thiagarajan Madheswaran, Jithendra Panneerselvam, Anil Philip Kunnath, Gaurav Gupta, Saurabh Satija, Meenu Mehta, Philip Michael Hansbro, Trudi Collet, Kamal Dua* and Dinesh Kumar Chellappan*


DOI: 10.2174/1381612826666200610111013


Review Article

Inflammatory bowel diseases: The role of gut microbiota

, 2020; 26(25): 2951-2961.

Cristiana De Musis, Lucia Granata, Marcello Dallio, Agnese Miranda, Antonietta G. Gravina and Marco Romano*


DOI: 10.2174/1381612826666200420144128


Review Article

Vaccinium myrtillus l. Fruits as a novel source of phenolic compounds with health benefits and industrial applications-a review

, 2020; 26(16): 1917-1928.

Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*


DOI: 10.2174/1381612826666200317132507


Review Article

Recent nano-based therapeutic intervention of bioactive sesquiterpenes: Prospects in cancer therapeutics

, 2020; 26(11): 1138-1144.

Mohammad A. Ansari*, Khan F. Badrealam, Asrar Alam, Saba Tufail, Gulshan Khalique, Mohammad J. Equbal*, Mohammad A. Alzohairy, Ahmad Almatroudi, Mohammad N. Alomary and Faheem H. Pottoo


DOI: 10.2174/1381612826666200116151522


Review Article (Mini-Review)

New insights about regulatory T cells distribution and function with exercise: The role of immunometabolism

, 2020; 26(9): 979-990.

Gilson P. Dorneles*, Aline A.Z. dos Passos, Pedro R.T. Romão and Alessandra Peres*


DOI: 10.2174/1381612826666200305125210


Review Article

Type 1 diabetes and physical exercise: Moving (forward) as an adjuvant therapy

, 2020; 26(9): 946-957.

Othmar Moser*, Max L. Eckstein, Daniel J. West, Nandu Goswami, Harald Sourij and Peter Hofmann


DOI: 10.2174/1381612826666200108113002


Review Article (Mini-Review)

EPO and EPO-receptor system as potential actionable mechanism for the protection of brain and heart in refractory epilepsy and SUDEP

, 2020; 26(12): 1356-1364.

Jerónimo Auzmendi , María B. Puchulu, Julio C. G. Rodríguez , Ana M. Balaszczuk , Alberto Lazarowski and Amalia Merelli *


DOI: 10.2174/1381612826666200219095548



Most Accessed Articles

Novel Phytochemical Constituents and their Potential to Manage Diabetes

, 2021; 27(6): 775-788.

Shaik Ibrahim Khalivulla*, Arifullah Mohammed* and Kokkanti Mallikarjuna


DOI: 10.2174/1381612826666201222154159


Epidemiology of Non-alcoholic Fatty Liver Disease in North America

, 2020; 26(10): 993-997.

Tamoore Arshad, Pegah Golabi, Linda Henry and Zobair M. Younossi*


DOI: 10.2174/1381612826666200303114934


Heart Failure in Diabetes Mellitus: An Updated Review

, 2020; 26(46): 5933-5952.

Catrin Sohrabi, Bunny Saberwal, Wei-Yao Lim, Dimitris Tousoulis, Syed Ahsan and Nikolaos Papageorgiou*


DOI: 10.2174/1381612826666201118091659


Novel Antidiabetic Agents: Cardiovascular and Safety Outcomes

, 2020; 26(46): 5911-5932.

Gerasimos Siasos*, Evanthia Bletsa, Panagiota K. Stampouloglou, Stavroula A. Paschou, Evangelos Oikonomou, Vasiliki Tsigkou, Alexios S. Antonopoulos, Manolis Vavuranakis and Dimitrios Tousoulis


DOI: 10.2174/1381612826666201109110107


Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty

, 2021; 27(5): 737-746.

Johny Bajgai, Kyu-Jae Lee*, Md. Habibur Rahman, Ailyn Fadriquela and Cheol-Su Kim


DOI: 10.2174/1381612826666200925124235





Molecular Hydrogen Application in Stroke: Bench to Bedside

, 2021; 27(5): 703-712.

Lei Huang, Cameron Lenahan, Warren Boling, Jiping Tang and John H. Zhang*


DOI: 10.2174/1381612826666200917152316


Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

, 2021; 27(5): 610-625.

Jan Slezak*, Branislav Kura, Tyler W. LeBaron, Pawan K. Singal, Jozef Buday and Miroslav Barancik


DOI: 10.2174/1381612826666200821114016


Perspective of Molecular Hydrogen in the Treatment of Sepsis

, 2021; 27(5): 667-678.

Bo Qi, Yang Yu, Yaoqi Wang, Yuzun Wang, Yonghao Yu and Keliang Xie*


DOI: 10.2174/1381612826666200909124936




Peripheral Artery Disease in Diabetes Mellitus: Focus on Novel Treatment Options

, 2020; 26(46): 5953-5968.

Andrea Demarchi, Alberto Somaschini, Stefano Cornara and Emmanuel Androulakis*


DOI: 10.2174/1389201021666201126143217




Editor-in-Chief

graphic
Alessandro Antonelli
(12,288 citations)
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Executive Editor

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureate on Editorial Board

graphic
Andrew V. Schally
(USA)

Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks.
Scopus CiteScore Metrics: 2.32

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