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Current Pharmaceutical Design

Volume 25, 46 Issues, 2019
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

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  • 148th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 25

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Number 9



Review Article

3D Printing Technology: A New Milestone in the Development of Pharmaceuticals

, 25(9): 937 - 945

Anish Chandekar, Dinesh K. Mishra*, Sanjay Sharma, Gaurav K. Saraogi, Umesh Gupta and Gaurav Gupta


DOI: 10.2174/1381612825666190507115504


Review Article



Review Article

Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments

, 25(9): 956 - 968

Elisa Magli, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Irene Saccone, Vincenzo Santagada, Giuseppe Caliendo* and Beatrice Severino


DOI: 10.2174/1381612825666190404115424


Review Article

Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment

, 25(9): 969 - 986

Allison B. Reiss*, Andrew Silverman, Muhammed Khalfan, Nicholas A. Vernice, Lora J. Kasselman, Steven E. Carsons and Joshua De Leon


DOI: 10.2174/1381612825666190430113212


General Review Article

Bioavailability Enhancement of Poorly Soluble Drugs: The Holy Grail in Pharma Industry

, 25(9): 987 - 1020

Mamunur Rashid, Mohd Yaseen Malik, Sandeep K. Singh, Swati Chaturvedi, Jiaur R Gayen and Muhammad Wahajuddin*


DOI: 10.2174/1381612825666190130110653


Systemic Review Article



General Research Article



Articles Ahead of Print

An Overview on Stem Cells in Tissue Regeneration


Rajasekar Seetharaman, Anjum Mahmood, Prashant Kshatriya, Divyang Patel and Anand Srivastava*


DOI: 10.2174/1381612825666190705211705
View Abstract




Nanoemulsions Loaded with Amphotericin B: Development, Characterization and Leishmanicidal Activity


Gabriela Muniz Félix Araújo, Alana Rafaela Albuquerque Barros, João Augusto Oshiro-Junior, Leonardo Ferreira Soares, Louisianny Guerra da Rocha, Ádley Antonini Neves de Lima, José Alexsandro da Silva, Attilio Converti* and Bolívar Ponciano Goulart de Lima Damasceno


DOI: 10.2174/1381612825666190705202030
View Abstract



Natural Products Derived from the Mediterranean Diet with Antidiabetic Activity: from Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator Compounds


Georgia - Eirini Deligiannidou, Elena Philippou, Melita Vidakovic, Wim Vanden Berghe, Alexandros Heraclides, Nevena Grdovic, Mirjana Mihailovic and Christos Kontogiorgis*


DOI: 10.2174/1381612825666190705191000
View Abstract


Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella Seed Oil) and Evaluation of their Antioxidant and Cytoprotective Activities


Amira Zarrouk, Lucy Martine, Stéphane Grégoire, Thomas Nury, Wiem Meddeb, Emmanuelle Camus, Asmaa Badreddine, Philippe Durand, Amira Namsi, Aline Yammine, Boubker Nasser, Mondher Mejri, Lionel Bretillon, John J. Mackrill, Mustapha Cherkaoui-Malki, Mohamed Hammami and Gérard Lizard*


DOI: 10.2174/1381612825666190705192902
View Abstract


Is There Something Fishy About Fish Oil?


Miloš Šunderić, Dragana Robajac, Nikola Gligorijević, Goran Miljuš, Olgica Nedić, Katarina Smilkov, Darinka Gjorgieva Ackova, Vesna Rudić-Grujić and Ana Penezić


DOI: 10.2174/1381612825666190705185800
View Abstract


What Can We Learn from Sarcopenia with Curarisation in the Context of Cancer Surgery? A Review of the Literature


Georges Samouri, Alexandre Stouffs, Lionel Vander Essen, Olivier Simonet, Marc De Kock and Patrice Forget*


DOI: 10.2174/1381612825666190705185033
View Abstract



Abstracts Ahead of Print




Dendrimer based nanoarchitectures in diabetes management: An overview


Vijay Mishra*, Nishika Yadav, Gaurav Saraogi , Murtaza M. Tambuwala and Namita Giri


DOI: 10.2174/1381612825666190716125332
View Abstract



Adenosine A2A Receptor as a Potential Drug Target – Current Status and Future Perspectives


Omar Husham Ahmed Al-Attraqchi, Mahesh Attimarad, Katharigatta N. Venugopala, Anroop Nair* and Noor Husham Ahmed Al-Attraqchi


DOI: 10.2174/1381612825666190716113444
View Abstract




Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b And A3 Adenosine Receptors


Sumit Jamwal, Ashish Mittal, Puneet Kumar*, Dana Mahmoud Alhayani and Amal Al-Aboudi


DOI: 10.2174/1381612825666190716112319
View Abstract



Published Contents

Editor's Choice



Molecular Basis of Modulating Adenosine Receptors Activities

, 2019; 25(7): 817 - 831

Mohammed Nooraldeen Mahmod Al-Qattan* and Mohd Nizam Mordi*


DOI: 10.2174/1381612825666190304122624



The Low Molecular Weight Brain-derived Neurotrophic Factor Mimetics with Antidepressant-like Activity

, 2019; 25(6): 729 - 737

Tatiana A. Gudasheva*, Polina Povarnina, Alexey V. Tarasiuk and Sergey B. Seredenin


DOI: 10.2174/1381612825666190329122852



Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia

, 2019; 25(5): 505 - 527

Emilie Hitzerd*, Michelle Broekhuizen, Rugina I. Neuman, Katrina M. Mirabito Colafella, Daphne Merkus, Sam Schoenmakers, Sinno H.P. Simons, Irwin K.M. Reiss and A.H. Jan Danser


DOI: 10.2174/1381612825666190405145228




Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future

, 2019; 25(3): 242 - 250

Keita Shibata, Terumasa Hashimoto, Takuro Miyazaki*, Akira Miyazaki and Koji Nobe


DOI: 10.2174/1381612825666190319115018



Doxorubicin-induced Cardiotoxicity and Cardioprotective Agents: Classic and New Players in the Game

, 2019; 25(2): 109 - 118

Felipe dos Santos Arruda, Fernanda Dias Tomé, Marina Pacheco Miguel, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Erica Carolina Campos, Danilo Figueiredo Soave and Mara Rúbia Nunes Celes*


DOI: 10.2174/1381612825666190312110836



Interleukin-23 Blockers: Born to be First-line Biologic Agents in Inflammatory Bowel Disease?

, 2019; 25(1): 25 - 31

Marjorie C. Argollo, Mariangela Allocca, Federica Furfaro, Laurent Peyrin-Biroulet and Silvio Danese*


DOI: 10.2174/1381612825666190313140811




Open Access Articles

Effects of As2O3 and Resveratrol on the Proliferation and Apoptosis of Colon Cancer Cells and the hERG-mediated Potential Mechanisms

, 2019; 25: 1 - 7 (E-Pub Ahead of Print)

Fengmei Li, Caichuan Yan, Yuhao Zhang, Yang Li, Mingzhu Li, Fang Wang, Guocui Zhang, Yuexin Li, Baoxin Li* and Xin Zhao






Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy

, 2018; 24(41): 4911 - 4920

Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*





Novel Data on the Prevalence, Identification, Scouting, and Treatment of Familial Hypercholesterolaemia

, 2018; 24(31): 3597 - 3598

Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos and Vasilios G. Athyros





Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24(26): 3143 - 3151

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky




Novel Technologies for Dipeptide Drugs Design and their Implantation

, 2018; 24(26): 3020 - 3027

Tatiana A. Gudasheva*, Rita U. Ostrovskaya and Sergey B. Seredenin




Coronary Microcirculation in Ischemic Heart Disease

, 2018; 24(25): 2893 - 2899

Axel R. Pries*, Wolfgang M. Kuebler and Helmut Habazettl




Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example

, 2018; 24(22): 2530 - 2540

Jian Han, Yonghong Xia, Lejun Lin, Zuoguang Zhang, Hui Tian and Kefeng Li*





Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production

, 2018; 24(18): 2012 - 2022

Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*




Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24(13): 1366 - 1376

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*




Development of Peptide Vaccines in Dengue

, 2018; 24(11): 1157 - 1173

Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*





Most Cited Articles

Review Article

Polyphenols: Potential use in the prevention and treatment of cardiovascular diseases

, 1 January 2018; 24(2): 239-258.

Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo F.G. Cicero, Giuseppe Lippi, Manfredi Rizzo*, Peter P. Toth and Maciej Banach


DOI: 10.2174/1381612824666180130112652


Review Article

Curcumin: A natural pan-HDAC inhibitor in cancer

, 1 January 2018; 24(2): 123-129.

Sara Saffar Soflaei, Amir Abbas Momtazi-Borojeni, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar*


DOI: 10.2174/1381612823666171114165051


Review Article

Recent findings in molecular basis of inflammation and anti-inflammatory plants

, 2018; 24(14): 1551-1562.

Sedigheh Kazemi, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei*


DOI: 10.2174/1381612824666180403122003


Review Article

Colchicine pharmacokinetics and mechanism of action

, 2018; 24(6): 659-663.

Christos Angelidis*, Zoi Kotsialou, Charalampos Kossyvakis, Agathi-Rosa Vrettou, Achilleas Zacharoulis, Fotios Kolokathis, Vasilios Kekeris and Georgios Giannopoulos


DOI: 10.2174/1381612824666180123110042


Review Article

Rapid-acting antidepressants

, 2018; 24(22): 2556-2563.

Jeffrey M. Witkin*, Daniel E. Knutson, Gabriel J. Rodriguez and Samuel Shi


DOI: 10.2174/1381612824666180730104707


Review Article

Signaling pathways in inflammation and anti-inflammatory therapies

, 2018; 24(14): 1449-1484.

Yiu To Yeung, Faisal Aziz, Angelica Guerrero-Castilla and Sandro Arguelles*


DOI: 10.2174/1381612824666180327165604


Review Article

Curcumin as an adjunct therapy and microRNA modulator in breast cancer

, 1 January 2018; 24(2): 171-177.

Saeed Norouzi, Muhammed Majeed, Matteo Pirro, Daniele Generali and Amirhossein Sahebkar*


DOI: 10.2174/1381612824666171129203506


Research Article

PNitro-Tyr-PseAAC: Predict nitrotyrosine sites in proteins by incorporating five features into Chou’s general PseAAC

, 2018; 24(34): 4034-4043.

Ahmad W. Ghauri, Yaser D. Khan, Nouman Rasool, Sher A. Khan* and Kuo-Chen Chou


DOI: 10.2174/1381612825666181127101039


Review Article

The role of formyl peptide receptors for immunomodulatory activities of antimicrobial peptides and peptidomimetics

, 2018; 24(10): 1100-1120.

Sarah Line Skovbakke*, Andre Holdfeldt, Huamei Forsman, Johan Bylund and Henrik Franzyk*


DOI: 10.2174/1381612824666180403123233


Review Article

Placental exosomes during gestation: Liquid biopsies carrying signals for the regulation of human parturition

, 2018; 24(9): 974-982.

Carlos Salomon*, Zarin Nuzhat, Christopher L. Dixon and Ramkumar Menon*


DOI: 10.2174/1381612824666180125164429


Review Article

Antibacterial coatings based on chitosan for pharmaceutical and biomedical applications

, 2018; 24(8): 866-885.

Juliana Miguel Vaz, Daniele Pezzoli, Pascale Chevallier, Clayton Souza Campelo, Gabriele Candiani and Diego Mantovani*


DOI: 10.2174/1381612824666180219143900




Research Article

Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity

, 2018; 24(5): 576-594.

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo


DOI: 10.2174/1381612823666170711112510




Most Accessed Articles

Advances in Binding Free Energies Calculations: QM/MM-Based Free Energy Perturbation Method for Drug Design

, 2013; 19(26): 4674-4686.

R.S. Rathore, M. Sumakanth, M. Siva Reddy, P. Reddanna, Allam Appa Rao, Mark D. Erion and M.R. Reddy


DOI: 10.2174/1381612811319260002


Recent Advances in Cancer Therapy: An Overview

, 2010; 16(1): 3-10.

A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals and G. Capella


DOI: 10.2174/138161210789941847


Reversal of Novel Anticoagulants in Emergent Surgery and Trauma: A Comprehensive Review and Proposed Management Algorithm

, 2018; 24(38): 4540-4553.

Leonidas Palaiodimos*, Jeremy Miles, Damianos G. Kokkinidis, Christos Barkolias, Anil K. Jonnalagadda, Dimitrios Papaconstantinou, Maximos Frountzas, Evangelos P. Misiakos and Dimitrios Schizas


DOI: 10.2174/1381612825666181226150629


JAK Inhibition: The Most Promising Agents in the IBD Pipeline?

, 2019; 25(1): 32-40.

Agnès Fernández-Clotet, Jesús Castro-Poceiro and Julián Panés*


DOI: 10.2174/1381612825666190405141410



Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins

, 2018; 24(41): 4932-4946.

Huanbo Tan, Wencheng Su, Wenyu Zhang, Pengju Wang, Michael Sattler and Peijian Zou*


DOI: 10.2174/1381612825666190206105232


Computer-aided Drug Design and Drug Pharmacokinetic Prediction: A Mini-review

, 2018; 24(26): 3014-3019.

Jamshid Tabeshpour, Amirhossein Sahebkar*, Mohammad Reza Zirak, Majid Zeinali, Mahmoud Hashemzaei, Sajed Rakhshani and Saleh Rakhshani*


DOI: 10.2174/1381612824666180903123423



Novel Oral Anticoagulants in Peripheral Artery Disease: Current Evidence

, 2018; 24(38): 4511-4515.

A. Koutsoumpelis*, C. Argyriou, K.M. Tasopoulou, E.I. Georgakarakos and G.S. Georgiadis


DOI: 10.2174/1381612825666181226151959




Editor-in-Chief

William A. Banks
(29546 citations)
Seattle VA Puget Sound Health Care System
Room 810C, Building 1
1660 S. Columbian Way
Seattle, WA 98108
USA

Biography View Full Editorial Board

Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks, who is the current Editor-in-Chief serving since 1995.
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Scopus CiteScore Metrics: 1.15

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