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"Current Pharmaceutical Design is a necessity for scientists working in the multidisciplinary fields encompassing the areas of drug design and discovery."

Annette M. Doherty
Pfizer Global R&D France

Forthcoming Special Issues

An Approach to the Theoretical and Experimental Design of Fused Compounds in the Treatment of Mental and Motor Dysfunctions


Guest Editor(s): Eduardo Sobarzo-Sánchez
Tentative Publication Date: October, 2018
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Special Issues - In-Press

Recent advances towards the treatment of depressive disorders


Guest Editor(s): Kefeng Li, Xu Wang
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Published Special Issues

Managing strategies for diverse diseases: Challenges from bench to bedside in successful drug discovery and development


Current Pharmaceutical Design, Volume 23, Number 11
Guest Editor(s): Mohammad Amjad Kamal, Nigel H. Greig

Authors' Comments
Thank you for the high quality of your services and it was such a pleasure and learning experience working with you.

Menglin Li
(School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 100029, China)


Current Pharmaceutical Design

,

Volume 24

-

Number 21



Editorial   Open Access



Review Article



Review Article



Review Article



Review Article

Pharmaceutical Strategies for Stabilizing Drug Nanocrystals

, 24(21): 2362 - 2374

Hyerim Yang, Hyeongmin Kim, Sumin Jung, Hyeyeon Seo, Shofa Khoirun Nida, Seung-Yup Yoo and Jaehwi Lee*


DOI: 10.2174/1381612824666180515125247


Review Article



Review Article



Review Article



Articles Ahead of Print

Prevalence, Identification, and Scouting for Familial Hypercholesterolaemia including Registries


Matilda Florentin, Michael S. Kostapanos, Moses S. Elisaf and Evangelos N Liberopoulos*


View Abstract View on PubMed


New horizons in the pathogenesis, pathophysiology and treatment of familial hypercholesterolaemia


Margus Viigimaa*, Silver Heinsar , Dragan Lovic, Alexandra Katsimardou, Alexia Piperidou and Davit Duishvili


View Abstract View on PubMed



Multimodal Treatment of Homozygous Familial Hypercholesterolemia


Thomas Gossios*, Ioanna Zografou, Veta Simoulidou, Athina Pirpassopoulou, Konstantinos Christou and Asterios Karagiannis


View Abstract View on PubMed



Novel Technologies for Dipeptide Drugs Design and their Implantation


Tatiana A. Gudasheva*, Rita U. Ostrovskaya and Sergey B. Seredenin


View Abstract View on PubMed



Current Status on the Effect of Diterpenes on Hepatic System


Marcia Fernanda Correia Jardim Paz, Muhammad Torequl Islam, Shams Tabrez*, Chelapram K. Firoz, Nasimudeen R Jabir, Mohammad Amjad Kamal, Ana Amelia de Carvalho Melo-Cavalcante and Fernanda Regina de Castro Almeida


View Abstract View on PubMed


Protective Role of Endogenous PACAP in Inflammation-induced Retinal Degeneration


Alexandra Vaczy, Petra Kovari, Krisztina Kovacs, Kinga Farkas, Edina Szabo, Timea Kvarik, Bela Kocsis, Balazs Fulop, Tamas Atlasz* and Dora Reglodi


View Abstract View on PubMed


Protective Mechanisms of Butyrate on Inflammatory Bowel Disease


Joao Paulo Bastos Silva, Kely Campos Navegantes-Lima, Ana Ligia Brito de Oliveira, Davila Valentina Silva Rodrigues, Silvia Leticia de Franca Gaspar, Valter Vinicius Silva Monteiro, Davi Pereira Moura and Marta Chagas Monteiro*


View Abstract View on PubMed


Abstracts Ahead of Print

A Meta-analysis of Randomized Control Trials: the Impact of Vitamin C Supplementation on Serum CRP and serum hs-CRP Concentrations


Sadegh Jafarnejad*, Virginia Boccardi, Banafshe Hosseni, Mohsen Taghizadeh and Zahra Hamedifard


View Abstract


Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases


Fabio Virgili, Roberto Ambra, Jacqueline McCormack, Elizabeth Ellen Simpson, Donatella Ciarapica, Lorenzo Barnaba, Elena Azzini and Angela Polito*


View Abstract


From Molecular Mechanism to the Etiology of Sjogren Syndrome


Wei Wei, Syed Sayeed Ahmad, Shuang Chi, Yu Xie, Mohammad Amjad Kamal and Jiang Li*


View Abstract


Single Probiotic versus Multiple Probiotics - A Debate in Current Scenario for Alleviating Health Benefits


Siva Kumar, Nagendra Sastry Yarla, Vijayendra Mishra, Mohamed Abdel Daim, Bechan Sharma, G M Ashraf, R Reggi , M Palmery, Ilaria Peluso* and Mohammad Amjad Kamal*


View Abstract



Influence of Hormones on Sjögren’s syndrome


Liu Yang, Wei Wei, Xi He, Yu Xie, Mohammad Amjad Kamal and Jiang Li*


View Abstract


Phytochemistry, traditional uses and pharmacological profile of rose hip: A review.


Zahra Ayati, Mohammad Sadegh Amiri , Mahin Ramezani , Elahe Delshad, Amirhossein Sahebkar* and Seyed Ahmad Emami


View Abstract


Should we consider lipoprotein (a) in cardiovascular disease risk assessment in patients with familial hypercholesterolaemia?


Panagiotis Anagnostis*, Pavlos Siolos, Dimitrios Krikidis, Dimitrios G. Goulis and John C. Stevenson


View Abstract



Pharmacology of PCSK9 inhibitors: Current status and future perspectives


Aikaterini N. Tsouka, Constantinos C. Tellis and Alexandros D. Tselepis*


View Abstract


Editor's Choice

Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art

, 2018; 24(21): 2508 - 2512

Joana R. Campos, Ana R. Fernandes, Patricia Severino, Maria L. Gracia, Selma B. Souto and Eliana B. Souto*


DOI: 10.2174/1381612824666180522092740



Parkinson’s Disease: Alpha Synuclein, Heme Oxygenase and Biotherapeutic Countermeasures

, 2018; 24(20): 2317 - 2321

David D. Haines*, Maxim V. Trushin, Stephen Rose, Iloki Assanga Simon Bernard and Fadia F. Mahmoud


DOI: 10.2174/1381612824666180717161338






Diabetes-Related Neurological Implications and Pharmacogenomics

, 2018; 24(15): 1695 - 1710

Camilo Andres Rojas-Carranza, Rosa Helena Bustos-Cruz*, Carmen Juliana Pino-Pinzon, Yeimy Viviana Ariza-Marquez, Rosa Margarita Gomez-Bello and Marisa Canadas-Garre


DOI: 10.2174/1381612823666170317165350



The Role of Inflammation in Neurological Disorders

, 2018; 24(14): 1485 - 1501

Diana Degan, Raffaele Ornello, Cindy Tiseo, Antonio Carolei, Simona Sacco and Francesca Pistoia*


DOI: 10.2174/1381612824666180327170632



Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24(13): 1366 - 1376

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*


DOI: 10.2174/1381612824666171201115126




Immunotheraphy in Allergic Diseases

, 2018; 24(11): 1174 - 1194

Albert Roger, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens, Clara Padro, Sira Miquel, Carolina Elduque and Eva M. Martinez-Caceres*


DOI: 10.2174/1381612824666180116094048



Open Access Articles


Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production

, 2018; 24(18): 2012 - 2022

Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*




Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24(13): 1366 - 1376

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*




Development of Peptide Vaccines in Dengue

, 2018; 24(11): 1157 - 1173

Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*





Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2018; 24(5): 576 - 594

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo






Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24: 1 - 9 (E-Pub Ahead of Print)

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky





IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development

, 2017; 23(38): 5964 - 5970

Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard




A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension

, 2017; 23(34): 5191 - 5199

Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*




A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure

, 2017; 23(34): 5115 - 5124

Yong Wang*, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu* and Wei Wang*





DNA Base Excision Repair: The Achilles' Heel of Tumour Cells and their Microenvironment?

, 2017; 23(32): 4758 - 4772

Mattia Poletto *, Arnaud J. Legrand * and Grigory L. Dianov*





Most Cited Articles

Autism: Pathophysiology and Promising Herbal Remedies

, 2016; 22(3): 277-285.

Mahmoud Bahmani, Amir Sarrafchi, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei


DOI: 10.2174/1381612822666151112151529


Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature

, 2016; 22(1): 28-51.

Paolo Giorgini, Paolo Di Giosia, Davide Grassi, Melvyn Rubenfire, Robert D. Brook and Claudio Ferri


DOI: 10.2174/1381612822666151109111712



Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers

, 2016; 22(34): 5257-5269.

Hamid Reza Mirzaei, Amirhossein Sahebkar, Mohsen Mohammadi, Reza Yari, Hossein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafari and Hamed Mirzaei


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The potential for circulating microRNAs in the diagnosis of myocardial infarction: a novel approach to disease diagnosis and treatment

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DOI: 10.2174/1381612822666151112151924


Computer Aided Drug Design: Success and Limitations

, 2016; 22(5): 572-581.

Mohammad Hassan Baig, Khurshid Ahmad, Sudeep Roy, Jalaluddin Mohammad Ashraf, Mohd Adil, Mohammad Haris Siddiqui, Saif Khan, Mohammad Amjad Kamal, Ivo Provazník and Inho Choi


DOI: 10.2174/1381612822666151125000550


Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis

, 2016; 22(3): 328-349.

Lili Wang, Yu Li, Yubo Guo, Rufeng Ma, Min Fu, Jianzhao Niu, Sihua Gao and Dongwei Zhang


DOI: 10.2174/1381612822666151112145907


From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

, 2016; 22(34): 5270-5293.

Andreas H. Laustsen, Mikael Engmark, Christina Milbo, Jónas Johannesen, Bruno Lomonte, José María Gutiérrez and Brian Lohse


DOI: 10.2174/1381612822666160623073438




Most Accessed Articles

Recent Advances in Cancer Therapy: An Overview

, 2010; 16(1): 3-10.

A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals and G. Capella


DOI: 10.2174/138161210789941847



Polyphenols: Potential Use in the Prevention and Treatment of Cardiovascular Diseases

, 2018; 24(2): 239-258.

Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo F.G. Cicero, Giuseppe Lippi, Manfredi Rizzo*, Peter P. Toth and Maciej Banach


DOI: 10.2174/1381612824666180130112652



Signaling Pathways in Inflammation and Anti-inflammatory Therapies

, 2018; 24(14): 1449-1484.

Yiu To Yeung, Faisal Aziz, Angelica Guerrero-Castilla and Sandro Arguelles*


DOI: 10.2174/1381612824666180327165604




Role of Melatonin in the Inflammatory Process and its Therapeutic Potential

, 2018; 24(14): 1563-1588.

Livia Carrascal, Pedro Nunez-Abades, Antonio Ayala and Mercedes Cano*


DOI: 10.2174/1381612824666180426112832


A Critical Review of the Antipsychotic Effects of Cannabidiol: 30 Years of a Translational Investigation

, 2012; 18(32): 5131-5140.

Antonio Waldo Zuardi, Jose Alexandre S. Crippa, Jaime E.C. Hallak, Sagnik Bhattacharyya, Zerrin Atakan, Rocio Martin-Santos, Philip K. McGuire and Francisco Silveira Guimaraes


DOI: 10.2174/138161212802884681



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