Articles Ahead of Print

Chronic Inflammatory Diseases and Atherosclerotic Cardiovascular Disease: Innocent Bystanders or Partners in Crime?


Peter Riis Hansen *


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Potential Role of Inflammation in Associations between Particulate Matter and Heart Failure


Xiaotong Ji, Yingying Zhang, Guangke Li and Nan Sang*


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Is Statin Therapy Safe and Effective in Patients with Chronic Kidney Disease?


Venkatesh K Raman, Eleni Geladari and Vasilios Papademetriou*


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Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress


Jiang Liu, Megan N. Lilly and Joseph I. Shapiro*


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The Role of Inflammation in Epicardial Adipose Tissue in Heart Diseases


Zdenek Matloch, Anna Cinkajzlova, Milos Mraze and Martin Haluzik*


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Synthesis and Characterization of a New Benzoindole Derivative with Apoptotic Activity Against Colon Cancer Cells


Fatemeh Hajiaghaalipour*, Fadhil Lafta Faraj, Elham Bagheri, Hapipah Mohd Ali, Mahmood Ameen Abdulla and Nazia Abdul Majid


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Advanced Strategies in the Diagnosis and Treatment of Patients with Coronary Artery Disease and Heart Failure: When Heart Failure Causes Ischemia and Angiotensin Converting Enzyme Inhibitor and Betablockers Helps in Diuresis


Thach Nguyen*, Nguyen Van Lanh, Vo Minh Viet, Lam Hoang Phuc, Trung N Pham, Khanh Duong, Luke Ashwin Lawrence, Vien T Truong and Gianluca Rigatelli


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Effects of High Intensity Statin Therapy in the Treatment of Diabetic Dyslipidemia in Patients with Coronary Artery Disease


Marija Vavlukis* and Sasko Kedev


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Drug-Coated Balloons: Technologies and Clinical Applications


Huiying Ang, Jinjie Lin, Ying Ying Huang, Tze Tec Chong, Salvatore Cassese, Michael Joner and Nicolas Foin*


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The Role of Angiogenesis in Coronary Artery Disease: A Double-Edged Sword: Intraplaque Angiogenesis in Physiopathology and Therapeutic Angiogenesis for Treatment


Wen Wu, Xiaobo Li, Guangfeng Zuo, Jiangqin Pu, Xinlei Wu and Shaoliang Chen*


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Drug-Coated Balloons Applications in Interventional Cardiology


Gianluca Rigatelli* and Marco Zuin


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Thrombolytic Therapy in the Current ERA: Myocardial Infarction and Beyond


Patrick Proctor, Massoud A. Leesar and Arka Chatterjee*


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Antithrombotic Strategies in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention


Daorong Pan, Xiaomin Ren and Zuoying Hu*


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Pharmaceutical Cocrystals as an Opportunity to Modify Drug Properties: From the Idea to Application: A Review


Agnieszka Sokal* and Edyta Pindelska


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A Review on Oral Liquid as an Emerging Technology in Controlled Drug Delivery System


Sangmesh Raosaheb Torne, Angappan Sheela* and N C Sarada


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Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy


Yan-Bei Ren, Shang-Jun Sun and Shuang-Yin Han*


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Diet and Brain Health: Which Role for Polyphenols?


Vanessa Castelli, Davide Grassi, Raffaella Bocale, Michele d’Angelo, Andrea Antonosante, Annamaria Cimini, Claudio Ferri and Giovambattista Desideri*


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The Overlap Between Binge Eating Behaviors and Polycystic Ovarian Syndrome: An Etiological Integrative Model


Chiara Paganini*, Gregory Peterson, Vasilis Stavropoulos and Isabel Krug


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Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus


Sayed Sartaj Sohrab*, Sherif Aly El-Kafrawy, Zeenat Mirza, Mohammad Amjad Kamal and Esam Ibraheem Azhar


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Polyphenols and Microvascular Function in Humans: A Systematic Review


Kirsty A. Woodward, Richard Draijer, Dick H. J. Thijssen and David A. Low*


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Comparatively and Selectively Targeted Anti-Neoplastic Cytotoxicity of Three Immunopharmaceuticals with Covalently Bound Fludarabine, Gemcitabine and Dexamethasone Moieties Synthesized Utilizing Organic Chemistry Reactions in a Multi-Phase Regimen


Cody P. Coyne* and Lakshmi Narayanan


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Polyphenols: Inflammation


Midori Natsume*


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Influence of Length and Amino Acid Composition on Dimer Formation of Immunoglobulin based Chimera


Patidar Manoj, Yadav Naveen and Sarat Kumar Dalai*


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The Role of PET in Monitoring Therapy in Fungal Infections


Alfred O. Ankrah, Hans C. Klein, Lambert F.R. Span, Erik F.J. de Vries, Rudi A.J.O. Dierckx, Mike M. Sathekge and Andor W.J.M. Glaudemans*


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Past and Future of Ga-citrate for Infection and Inflammation Imaging


Mariza Vorster, J Buscombe*, Ziauddin Saad and Mike Sathekge


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Nuclear Medicine Imaging in Fever of Unknown Origin: The New Paradigm


Christopher J Palestro* and Charito Love


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FDG PET/CT Imaging in Diabetic Patients - A Special Emphasis on Imaging of Infection


Zohar Keidar*


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Imaging of Bacteria: Is there Any Hope for the Future Based on Past Experience?


Thomas Ebenhan, Elena Lazzeri and Olivier Gheysens*


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Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors


William B. Parker and Eric J. Sorscher*


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Pharmacological Aspects of Neuro-Immune Interactions


Vadim V. Tarasov, Nikita V. Kudryashov, Vladimir N. Chubarev, Tatiana S. Kalinina, George E. Barreto, Ghulam Md Ashraf and Gjumrakch Aliev*


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Editorial: Advances and Future Developments in Forensic Toxicology: From Standard Practices to New Psychoactive Substances


Francesco Paolo Busardo*, Simona Pichini and Frank T. Peters




Editorial: New Trends in Enzymatic Synthesis of Nucleic Acid Derivatives


Jesus Fernandez Lucas*




Editorial: Applications of Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC): State of the Art


Ana Catarina Silva*, Maria Helena Amaral, Jose Manuel Sousa Lobo and Hugo Almeida




The Economic Impact of Biosimilars on Chronic Immune-Mediated Inflammatory Diseases


Marta Pentek*, Zsombor Zrubka and Laszlo Gulacsi


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Lipid Nanoparticles for the Delivery of Active Natural Medicines


Huijie Xing, Huan Wang, Baojian Wu and Xingwang Zhang*


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Platform for Lipid Based Nanocarriers’ Formulation Components and their Potential Effects: A Literature Review


Ragwa Mohamed Farid*, Nancy Abdel Hamid Abou Youssef and Abeer Ahmed Kassem


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Immobilization Techniques Applied to the Development of Biocatalysts for the Synthesis of Nucleoside Analogue Derivatives


Jorge Abel Trelles* and Maria Jose Lapponiab


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The Experience with Biosimilars of Infliximab in Inflammatory Bowel Disease


Pedro Avila-Ribeiro*, Gionata Fiorino and Silvio Danese


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Ensuring the Consistency of Biosimilars


Isabel Andujar Perez, Ana Blas-Garcia*, Loreto Carmona and Juan V. Esplugues


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Intranasal Lipid Nanoparticles for the Treatment of Neurodegenerative Diseases


S. Cunha, H. Almeida, M. H. Amaral*, J. M. Sousa Lobo and A. C. Silva*


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The Role of Biosimilars in Patient Access to Therapeutic Antibodies for Immune Mediated Inflammatory Diseases


Mary Ann Chapman*, David Charles and Arturo Loaiza-Bonilla


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Substrate Spectra of Nucleoside Phosphorylases and their Potential in the Production of Pharmaceutically Active Compounds


Heba Yehia, Sarah Kamel, Katharina Paulick, Peter Neubauer and Anke Wagner*


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Risk Assessment and Monitoring of Antibody Responses to Biosimilars in Chronic Inflammatory Diseases


Iris Detrez and Ann Gils*


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The Experience with Biosimilars of Infliximab in Rheumatic Diseases


Valderilio Feijó Azevedo, Igor Age Kos and Leonardo Ariello


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Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach


Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*


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Biosimilars: From Extrapolation into Off Label Use


Sizheng Zhao, Jagdish R Nair and Robert J Moots*


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Polyphenols Effect on Circulating Lipids and Lipoproteins: From Biochemistry to Clinical Evidence


Arrigo FG. Cicero* and Alessandro Colletti


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Polyphenols: Novel Signaling Pathways


Marie-Louise Ricketts* and Bradley S Ferguson


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Curcumin as an Adjunct Therapy and microRNA Modulator in Breast Cancer


Saeed Norouzi, Muhammed Majeed, Matteo Pirro, Daniele Generali and Amirhossein Sahebkar*


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Ellagic Acid: A Logical Lead for Drug Development?


Abolfazl Shakeri, Mohammad Reza Zirak and Amirhossein Sahebkar*


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Seizures and Antiepileptic Drugs: From Pathophysiology to Clinical Practice


Nihan Çarçak and Çigdem Özkara*


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Effect of Metformin on Plasma Fibrinogen Concentrations: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials


Luis E Simental-Mendia, Matteo Pirro, Stephen L Atkin, Maciej Banach, Dimitri P Mikhailidis and Amirhossein Sahebkar*


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Epigenetic Alterations in DNA and Histone Modifications Caused by Depression and Antidepressant Drugs: Lessons from the Rodent Models


Dimitry A. Chistiakov , Yuri V. Bobryshev* and Vladimir P. Chekhonin


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NTP Regeneration and its Application in the Biosynthesis of Nucleotides and their Derivatives


Qingbao Ding* and Ling Oua


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Schistosoma mansoni Purine and Pyrimidine Biosynthesis: Structures and Kinetic Experiments in the Search for the Best Therapeutic Target


Vitor Hugo Balasco Serrão, Humberto D’Muniz Pereira*, Juliana Roberta Torini de Souza and Larissa Romanello


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Metabolism of Nucleosides and Nucleotides Prodrugs


Coralie De Schutter, Maryam Ehteshami, Emily T. Hammond, Franck Amblard and Raymond F. Schinazi*


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1,N6-ethenoadenine and other Fluorescent Nucleobase Analogues as Substrates for Purine-Nucleoside Phosphorylases: Spectroscopic and Kinetic Studies


Jacek Wierzchowski*, Alicja Stachelska-Wierzchowska, Beata Wielgus-Kutrowska and Agnieszka Bzowska


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Level V Metastasis, a Novel Predicative Factor for Recurrence in N1b Papillary Thyroid Carcinoma


Yifeng Wu, Jianjun Li, Xianjiang Wu and Lei Dai*


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Hypertension in 2017: Update in Treatment and Pharmaceutical Innovations


Mehmet Evren Okur, Ioannis D. Karantas, Neslihan Üstündağ Okur and Panoraia I. Siafaka*


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Development of Peptide Vaccines in Dengue


Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*


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Seizures and Anticonvulsants in Brain Tumours: Frequency, Mechanisms and Anti-Epileptic Management


Charles Vecht*, Louis Royer-Perron, Caroline Houillier and Gilles Huberfeld


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Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis


Rita Citraro, Antonio Leo, Andrew Constanti and Emilio Russo*


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Statins and Inflammation in Cardiovascular Disease


Georgia Vogiatzi, Evangelos Oikonomou*, Gerasimos Siasos, Sotiris Tsalamandris, Alexandros Briasoulis, Emmanuel Androulakis, George Latsios, Spyridon Papaioannou, Konstantinos Tsioufis and Dimitris Tousoulis


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Effective Delivery Routes and Strategies for Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC)


Divyesh H. Shastri*


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Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or İllusion?


Melike Uner*, Sukran Damgalı, Samet Ozdemir and Burak Celik


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Lipid-based Nanosized Delivery Systems for Fluoroquinolones: A Review


Pio Maria Furneri, Virginia Fuochi and Rosario Pignatello*


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Lipid Based Nanoparticles as Inherent Reversing Agents of Multidrug Resistance in Cancer


Salma N. Tammam*


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An Update of Patents, Preclinical and Clinical Outcomes of Lipid Nanoparticulate Systems


Kamla Pathak*, Ravi Shankar and Monika Joshi


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Current Challenges and Future of Lipid Nanoparticles Formulations for Topical Drug Application to Oral Mucosa, Skin, and Eye


Viviane A. Guilherme, Ligia N.M. Ribeiro, Giovana Radomille Tofoli, Michelle Franz-Montan, Eneida de Paula and Marcelo Bispo de Jesus*


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Cocoa Polyphenols: Evidence from Epidemiological Studies


Chisa Matsumoto*


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Polyphenols, Antioxidants and the Sympathetic Nervous System


Rosa Maria Bruno and Lorenzo Ghiadoni*


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Curcumin: A Natural Pan-HDAC Inhibitor in Cancer


Sara Saffar Soflaei, Amir Abbas Momtazi, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar*


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Polyphenols: Anti-Platelet Nutraceutical?


Valeria Ludovici, Jens Barthelmes, Matthias P. Nägele, Andreas J. Flammer and Isabella Sudano*


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Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage


Sergio Davinelli, Juan Carlos Bertoglio, Ascanio Polimeni and Giovanni Scapagnini*


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Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes


Anna W. Sobańska* and Elżbieta Brzezińska


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The Effect of Physical Exercise on Neurogenesis Factor Production in Glial Cells


Jorge M. Moreno-Collazos* and Eva S. Orti


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Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases


Julio Cesar Martinez Lozano*, Rosa Margarita Gómez, Andres Gabriel Zarate Sanabria, Giovanny Jubiz and Sonia Del Pilar Otalora Valderrama


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Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities


Laura Rosa Pisani, Marina Nikanorova, Cecilie Johannessen Landmark, Svein Ivar Johannessen and Francesco Pisani*


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Antiepileptic Drugs in the Neurosurgical Intensive Care


Panayiotis N. Varelas* and Matthew Jones


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The Use of Antiepileptic Drugs in Paediatric Neurosurgical Conditions


Marios S. Themistocleous*, Dimitrios Giakoumettis, Konstantinos Margetis, George A. Alexiou and George Stranjalis


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The Prophylactic Use of Antiepileptic Drugs in Patients Scheduled for Neurosurgery


Barbara Miziak, Kinga Borowicz-Reutt, Radoslaw Rola, Barbara Blaszczyk, Miroslaw Czuczwar and Stanislaw J. Czuczwar*


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Ophthalmic Applications of SLN and NLC


Neslihan Ustundag Okur and Evren Homan Gokce*


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Development and Tailoring of Hybrid Lipid Nanocarriers


German A. Islan, Maximiliano L. Cacicedo, Boris Rodenak-Kladniew, Nelson Duran and Guillermo R. Castro*


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SLN- and NLC-Encapsulating Antifungal Agents: Skin Drug Delivery and their Unexplored Potential for Treating Onychomycosis


Tais Gratieri, Anna Paula Krawczyk–Santos, Priscila Bianca Rodrigues da Rocha, Marcilio Cunha–Filho, Guilherme Martins Gelfuso, Ricardo Neves Marreto and Stephania Fleury Taveira*


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Characterization Methods for Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC)


Velichka Andonova* and Petya Peneva


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Targeting Cancer Stem Cells and Non-Stem Cancer Cells: The Potential of Lipid- Based Nanoparticles


Ana Filipa Cruz, Nuno Andre Fonseca, Vera Moura, Sergio Simoes and Joao Nuno Moreira*


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Statins in Aortic Disease


Vicky Tsigkou*, Gerasimos Siasos*, Eva Mpletsa, Maria-Paraskevi Panoilia, Aggeliki Papastavrou, Giorgos Kokosias, Evangelos Oikonomou, Marina Zaromitidou, Manolis Vavuranakis, Christodoulos Stefanadis and Dimitris Tousoulis


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Antiepileptics for Post-Traumatic Seizure Prophylaxis after Traumatic Brain Injury


Alexander G. Chartrain, Kurt Yaeger , Rui Feng , Marios S. Themistocleous , Neha S. Dangayach, Konstantinos Margetis and Zachary L. Hickman *


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Antiepileptic Treatment Strategy in Vascular Malformations


Dimitrios Giakoumettis*, Konstantinos Margetis, George Stranjalis, Nikolaos Haliasos, Theodoros G. Papaioannou and Marios S. Themistocleous


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Epilepsy, Theories and Treatment Inside Corpus Hippocraticum


Gregory Tsoucalas*, Konstantinos Spengos, George Panayiotakopoulos, Theodoros Papaioannou and Marianna Karamanou


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Antiepileptic Drugs for Preventing Seizures in Patients with Chronic Subdural Hematoma


Pedro Moura Branco*, Bernardo Oliveira Ratilal, João Costa and Cristina Sampaio


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Efficacy, Duration and Timing of Withdrawal of Prophylactic Treatment with Antiepileptic Drugs in Neurosurgical Conditions


Daniel R. Calnan, Erin D’Agostino, Matthew R. Reynolds and Kimon Bekelis*


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Epilepsy, Comorbidities and Treatments


Alla Guekht*


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Current Surgical Options for the Epileptic Patients


Fahid T Rasul, Jarnail Bal, Erlick A Pereira, Martin Tisdall, Marios Themistocleus and Nikolaos Haliasos*


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Intraoperative Seizures: Anesthetic Drugs and Antiepileptic Drugs


Alberto Uribe*, Alix Zuleta-Alarcon, Mahmoud Kassem, Gurneet S. Sandhu and Sergio D. Bergese


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New Strategies for the Prevention and Treatment of Bone Loss - From Mechanical Loading Point of View


Ce Shi , Bai Yang* and Hongchen Sun*


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AED Strategy after Refractory Epilepsy Surgery


Andreas Zigouris, George A Alexiou*, Marios S. Themistocleous and Spyridon Voulgaris


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Anti-epileptic Drug (AED) Use in Subarachnoid Hemorrhage (SAH) and Intracranial Hemorrhage (ICH)


Rui Feng*, Justin Mascitelli, Alexander G. Chartrain, Konstantinos Margetis and J Mocco


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Epilepsy and Neurosurgery: Historical Highlights


Marianna Karamanou*, Gregory Tsoucalas, Marios Themistocleous, Dimitrios Giakoumettis, George Stranjalis and George Androutsos


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Statins and Vulnerable Plaque


Maria Drakopoulou, Konstantinos Toutouzas*, Archontoula Michelongona and Dimitrios Tousoulis


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Overview on Inhalable Nanocarriers for Respiratory Immunization


Rui C. Ferreira, Hermenegildo Neves, João F. Pinto and Carla M. Lopes*


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Statins in Peripheral Arterial Disease


Scott T. Chiesa, Nikos Papageorgiou and Marietta Charakida*


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Statins in Stable Angina Pectoris


Adam Ioannou, Nikolaos Papageorgiou *, Vincent McVaughan , Marietta Charakida , Dimitris Bertsias , Fay Zacharia, Gerasimos Siasos, George Latsios, Spyridon Papaioannou, Evangelos Oikonomou and Dimitris Tousoulis


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Graphene-Based Nanomaterials: Potential Tools for Neurorepair


Qing Wang , Yan-Hua Li, Wei-Jia Jiang, Jian-Guo Zhao, Bao-Guo Xiao , Guang-Xian Zhang* and Cun-Gen Ma


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Statins and Left Ventricular Function


Agamemnon Bakakos, Evangelos Oikonomou*, Georgia Vogiatzi , Gerasimos Siasos, Sotiris Tsalamandris , Alexios Antonopoulos , Costas Mourouzis, Petros Fountoulakis, Manolis Vavuranakis and Dimitris Tousoulis


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Perivascular Adipose Tissue as an Endocrine Organ: The Role of Statins


Fabio Sanna*, Marios Margaritis and Charalambos Antoniades


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Statins and Oxidative Stress in the Cardiovascular System


Marios Margaritis, Fabio Sanna and Charalambos Antoniades*


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Novel Treatment and New Drugs in Epilepsy Treatment


Elissavet. Eskioglou, M. P. Perrenoud, Phiilippe. Ryvlin and Jan. Novy*


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Optimising β-lactam Dosing in Neonates: A Review of Pharmacokinetics, Drug Exposure and Pathogens


Aline Fuchs*, Grace Li, Johannes Van Den Anker and Julia Bielicki


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Editorial: Polymeric Nanocarriers as Robust Platforms for Cancer Therapy


Ahmed O. Elzoghby *




Collaboration in Regulatory Science to Facilitate Therapeutic Development for Neonates


Susan K. McCune*, Yeruk Ager Mulugeta and Gerri R. Baer


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Developmental Pharmacokinetics in Neonates: Maturational Changes and Beyond


Karel Allegaert *, Paola Mian and John van den Anker


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Nasal Delivery of Antioxidants by Cholesterol-incorporated Liposomes Extends the Neuroprotective Time Window in Cerebral Ischemia


Seul Ki Min, Yeo Seon Kwon, Myung Kwon Cho and Hwa Sung Shin*


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The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis


Kenneth Blum, Panayotis K Thanos, Gene-Jack Wang, Marcelo Febo, Zsolt Demetrovics, Edward Justin Modestino*, Eric R. Braverman, David Baron, Rajendra D. Badgaiyan and Mark S. Gold


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Effects of Excitotoxic Lesion with Inhaled Anesthetics on Nervous System Cells of Rodents


Maria Fernanda Quiroz-Padilla*, Gemma Guillazo-Blanch, Magdy Y Sanchez, Maria Andrea Dominguez-Sanchez and Rosa Margaria Gomez


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Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis


Qian Xiang, Shuang Zhou, Joshua P. Lewis, Alan R. Shuldiner, Guanhua Ren and Yimin Cui


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A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway


Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun*, Luchen Shan* and Yuqiang Wang


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Statins in Aortic Stenosis


Karl Norrington, Emmanuel Androulakis*, Evangelos Oikonomou, Georgia Vogiatzi and Dimitris Tousoulis


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Biomarkers of Cardiovascular Risk in Haemodialysis Patients


Beata Franczyk, Anna Gluba-Brzózka* and Jacek Rysz


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Statins in Acute Coronary Syndromes


Manolis Vavuranakis*, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras and Dimitris Tousoulis


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Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree


P. Mian*, C.A.J. Knibbe, E.A.M. Calvier, D. Tibboel and K. Allegaert


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2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1


Pericles Calias*


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Purine and Pyrimidine Phosphoribosytransferases: A Versatile Tool for Enzymatic Synthesis of Nucleoside-5′-monophosphates


J. Del Arco and J. Fernández-Lucas*


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Whole Cell Biocatalysts for the Preparation of Nucleosides and their Derivatives


Elizabeth S. Lewkowicz and Adolfo M. Iribarren*


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Cellulose-based Nanocarriers as Platforms for Cancer Therapy


Ling-Yan Meng, Bin Wang, Ming-Guo Ma* and Jie-Fang Zhu*


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Current Delivery Strategies to Improve the Target of Cell Penetrating Peptides Used for Tumor-Related Therapeutics


Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He and Peng Zhang*


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Neonatal Pain, Still Searching for the Optimal Approach


Elizabeth Walter-Nicolet*, Laurent Calvel*, Geraldine Gazzo, Pierrick Poisbeau and Pierre Kuhn


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PBPK in Preterm and Term Neonates: A Review


Robin Michelet*, Jan Van Bocxlaer and An Vermeulen


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A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition


Ahmed Reda, Anke Raaijmakers, Saskia van Dorst, Charlotte G.G.M. Pauwels, Karel Allegaert, Mohamed A Elmonem, Rosalinde Masereeuw, Lambertus van den Heuvel, Elena Levtchenko and Fanny Oliveira Arcolino*


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Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs


Banu Bayram, Aykut Özgür, Lütfi Tutar and Yusuf Tutar*


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Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity


Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo


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Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells


Wen-bin Hua, Yu-kun Zhang, Xing-huo Wu, Liang Kang, Ji Tu, Kang-cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-jin Luo, Zeng-wu Shao and Cao Yang*


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Neonatal Plasticity of the Nociceptive System: Mechanisms, Effects, and Treatment of Repetitive Painful Procedures During NICU Admittance


N J Van den Hoogen*, J Patijn , D Tibboel and E A Joosten


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Aerosol: A Novel Vehicle in Pharmacotherapy in Neonates


Ronan MacLoughlin*, Colin Telfer, Andy Clark and James Fink


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Editorial: Novel Perspectives in the Treatment of Epilepsy


Umberto Aguglia* and Ettore Beghi




Experimental Treatment Options in Absence Epilepsy


Gilles van Luijtelaar*, Mehrnoush Zobeiri, Annika Lüttjohann and Antoine Depaulis


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The Roles of microRNAs in Regulating Chemotherapy Resistance of Non-Small Cell Lung Cancer


Xiaoxuan Wei, Xiaoyan Shen, Yanchen Ren and Weidong Hu*


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Discrepancies in Animal Models of Preterm Birth


Clarence R. Manuel, Charles R. Ashby and Sandra E. Reznik*


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Maternal Immunomodulation Therapy for Prevention of Preterm Birth and Prematurity-Related Morbidity: The New Era of Immuno-Perinatology


Shriddha Nayak, Jared Welling and Irina Burd*


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Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists


Mathieu Nadeau-Vallée, Dima Obari, Alexandra Beaudry-Richard, Estefania Marin Sierra, Alexandre Beaulac, Noémie Maurice, David M. Olson* and Sylvain Chemtob*


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Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research


Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen and David M. Aronoff*


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Pharmacology and Literature Review Based on Related Death and Non-Fatal Case Reports of the Benzofurans and Benzodifurans Designer Drugs


Bernardino Barceló Martín* and Isabel Gomila


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Update of Standard Practices for New Method Validation in Forensic Toxicology


Sarah M.R. Wille*, Wim Coucke, Thierry De Baere and Frank T. Peters


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Interest of Single Hair Analysis to Document Drug Exposure: Literature Review and a Case Report Involving Zuclopenthixol


Nathalie Allibe*, Pascal Kintz, Amandine Faure, François Paysant, Anne-Pascale Michard-Lenoir, Françoise Stanke-Labesque, Virginie Scolan and Hélène Eysseric-Guerin


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Mephedrone Concentrations in Cases of Clinical Intoxication


Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens and Magí Farré*


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Nanovesicular Formulations for Cancer Gene Therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo*


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Long-lasting Insulin Treatment Via a Single Subcutaneous Administration of Liposomes in Thermoreversible Pluronic® F127 Based Hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu* and Zhijun Yang*


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Anti-Cancer Drug Delivery Using Carbohydrate-Based Polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani*


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Statins and Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis


Alexandros Briasoulis*, Mohan Pala , Tesfaye Telila , Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi , Evangelos Oikonomou and Dimitris Tousoulis


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Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants


Robert B. Flint*, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit CP Koch, Ronald de Groot, Dick Tibboel, Catherijne AJ Knibbe, Irwin KM Reiss, Sinno HP Simons and DINO Research group


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PD-1/PD-L1 Inhibitors for Immuno-oncology: From Antibodies to Small Molecules


Qiaohong Geng, Peifu Jiao*, Peng Jin, Gaoxing Su, Jinlong Dong and Bing Yan*


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Statins in Diabetes Mellitus


Charalambos Vlachopoulos*, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, George Lazaros and Dimtris Tousoulis


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Editorial: Astrocyte-Targeted Therapeutic Strategies for Neurological Disorders


Ikuko Miyazaki *




IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development


Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard


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Sexual Dysfunction in Epilepsy and the Role of Anti-Epileptic Drugs


Mahinda Yogarajah and Marco Mula *


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Hair Analysis in Forensic Toxicology: An Updated Review with a Special Focus on Pitfalls


Pascal Kintz *


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Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review


JC. Alvarez*, N. Fabresse and IA. Larabi


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Nails in Forensic Toxicology: An Update


Renata Solimini*, Adele Minutillo, Chrystalla Kyriakou , Simona Pichini, Roberta Pacifici and Francesco Paolo Busardò


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Therapeutic Drug Monitoring in Neonates: What Makes them Unique?


P. Mian*, R. B. Flint, D. Tibboel, J. N. van den Anker, K. Allegaert and B. C.P. Koch


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Age-Appropriate Formulations Including Pharmaceutical Excipients in Neonatal Medicines


Karin Kogermann*, Jana Lass, Georgi Nellisd, Tuuli Metsvaht and Irja Lutsar


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Analgesics in Pregnancy: An Update on Use, Safety and Pharmacokinetic Changes in Drug Disposition


Hayley R Price and Abby C Collier*


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Modelling Bronchopulmonary Dysplasia in Animals: Arguments for the Preterm Rabbit Model


Thomas Salaets, Andre Gie, Bieke Tack, Jan Deprest and Jaan Toelen*


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Inflammation and Epilepsy: Preclinical Findings and Potential Clinical Translation


Gaetano Terrone, Alessia Salamone and Annamaria Vezzani*


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The Use of Hemodynamic and Cerebral Monitoring to Study Pharmacodynamics in Neonates


A. Smits, L. Thewissen, A. Dereymaeker, E. Dempsey, A. Caicedo and Gunnar Naulaers*


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Long-term Effects of Early Exposure to Stress, Pain, Opioids and Anaesthetics on Pain Sensitivity and Neurocognition


Gerbrich E. van den Bosch, Monique van Dijk, Dick Tibboel and Jurgen C. de Graaff*


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Diabetes-Related Neurological Implications and Pharmacogenomics


Rojas Carranza Camilo Andrés, Bustos Cruz Rosa Helena*, Pino Pinzón Carmen Juliana , Ariza Marquez Yeimy Viviana, Gómez Bello Rosa Margarita and Cañadas Garre Marisa


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Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases


Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V.Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T. Scotti, M. A.Kamal, Gjumrakch Aliev, Chinthalapally V. Rao, George Perry and Anupam Bishayee


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Role of Bradykinin in the Regulation of Endothelial Nitric Oxide Synthase Expression by Cardiovascular Drugs


Jin Bo Su*


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Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives


Antonio Gambardella*, Angelo Labate, Laura Mumoli, Iscia Lopes-Cendes and Fernando Cendes*


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Imaging Biomarkers of Anti-Epileptic Drug Action: Insights from Magnetic Resonance Imaging


Lorenzo Caciagli, Fenglai Xiao, Britta Wandschneider and Matthias J. Koepp*


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MiRNA-based Therapeutic Strategy in Lung Cancer


Guang Li, Jing Fang, Ying Wang, Hu Wang* and Cheng-Cao Sun*


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Role of miRNA in Lung Cancer-Potential Biomarkers and Therapies


Xiaohong Du, Jitai Zhang, Juping Wang*, Xiaoming Lin* and Feng Ding*


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MiRNA-based Therapeutics for Lung Cancer


Miaowei Wu, Guosheng Wang, Wei Tian, Yongchuan Deng* and Yibing Xu*


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Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer


Feng-Yun Gong, Tao Bai, Ding-Yu Zhang*, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu


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Good Practices in Forensic Toxicology


Olaf H. Drummer*


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LSD Detection and Interpretation in Hair


Camille Richeval, Delphine Allorge, X. Vanhoye and Jean-michel Gaulier*


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Overview of Forensic Toxicology, Yesterday, Today and in the Future


Heesun Chung* and Sanggil Choe


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Method Development in Forensic Toxicology


Frank T. Peters*, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei and Simona Pichini


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The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier


Junichi Matsumoto, Tessandra Stewart, William A. Banks and Jing Zhang*


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Allopurinol: Old Drug, New Indication in Neonates?


Kim V Annink, Axel R Franz, Jan B Derks, Mario Rüdiger, Frank van Bel and Manon J.N.L. Benders*


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Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data


Ebru Ergenekon, Héctor Rojas-Anaya, María Carmen Bravo, Charalampos Kotidis, Liam Mahoney and Heike Rabe*


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Alzheimer’s Disease and Parkinson’s Disease: A Review of Current Treatment Adopting a Nanotechnology Approach


Adriana Trompetero, Aldemar Gordillo, Carolina del Pilar Mora, María Cristina Velasquillo and Rosa Helena Bustos*


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Synthesis and Biological Evaluation of New Tyrosol-Salicylate Derivatives as Potential Anti-Inflammatory Agents


Rafael P. Aguiar*, Fahad S. Aldawsari, Luiz A. M. Wiirzler, Saulo E. Silva- Filho, Francielli M. S. Silva-Comar, Ciomar A. Bersani-Amado, Carlos A. Velázquez-Martínez and Roberto K. N. Cuman


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Formulation, Quality Control and Safety Issues of Nanocarriers Used for Cancer Treatment


Ismael D. Bianco*, Marcelo R. Ceballos, Cristian Casado, Viviana G. Dabbene, Carolina Rizzi and R. Kiyomi Mizutamari


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Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer


Iliyas Khan, Hitesh Kumar, Gaurav Mishra, Avinash Gothwal, Prashant Kesharwani and Umesh Gupta*


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Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments


Alexandra Muñoz Bonilla and Pilar Herrasti González *


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Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery


Jaleh Varshosaz*, Somayeh Taymouri and Erfaneh Ghassami


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Zein-based Nanocarriers as Potential Natural Alternatives for Drug and Gene Delivery: Focus on Cancer Therapy


Ahmed Elzoghby*, May Freag*, Hadeer Mamdouh and Kadria Elkhodairy


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Albumin Nanocarriers, γ - Irradiated Crosslinked, Combined with Therapeutic Drugs for Cancer Therapy


Macarena Siri, Estefanía Achilli, Mariano Grasselli and Silvia del V. Alonso*


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Using Properties of Tumor Microenvironments for Controlling Local, On-Demand Delivery from Biopolymer-Based Nanocarriers


Abdullah K. Alshememry, Suleiman S. El-Tokhy and Larry D. Unsworth*


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Ketogenic Diets in the Treatment of Epilepsy


Maurizio Elia*, Joerg Klepper, Baerbel Leiendecker and Hans Hartmann


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Management of Antiepileptic Treatment After Epilepsy Surgery - Practices and Problems


Guido Rubboli*, Anne Sabers, Peter Uldall and Kristina Malmgren


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Antiepileptic Treatments in Developing Countries


Jeremy Jost*, Athanase Millogo and Pierre-Marie Preux


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Treatment of Epileptic Encephalopathies


Simona Balestrini* and Sanjay M Sisodiya


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The Role of Exosomes and Exosome-derived microRNAs in Atherosclerosis


Xinjie Lu*


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Implications of Photophysical and Physicochemical Factors on Successful Application of Photodynamic Therapy


Shubhajit Paul, Paul Wan Sia Heng and Lai Wah Chan*


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Pivotal Roles of Interleukin-17 as the Epicenter of Bone Loss Diseases


Chongshan Liao, Chengfei Zhang and Yanqi Yang*


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Modulation of GABAA Receptors in the Treatment of Epilepsy


Eleonora Palma*, Gabriele Ruffolo, Pierangelo Cifelli, Cristina Roseti, Erwin A. van Vliet and Eleonora Aronica


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Update on Pharmacological Treatment of Progressive Myoclonus Epilepsies.


Edoardo Ferlazzo*, Dorothee Kasteleijn-Nolst Trenite, Gerrit-Jan de Haan, Felix Felix Nitschke, Saija Ahonen, Sara Gasparini and Berge A. Minassian


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Antiepileptic Drugs in Clinical Development: Differentiate or Die?


Gaetano Zaccara * and D. Schmidt


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Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review


Caterina Palleria, Giuseppe Cozza, Rajeshree Khengar, Vincenzo Libri and Giovambattista De Sarro*


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Nano-sized Ultrasound Contrast Agents for Cancer Therapy and Theranostics


Hao Li, Shenglong Gan, Shi-Ting Feng, Guofu Zhou, Zhi Dong, Rongqin Zheng* and Zi-Ping Li*


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Potentially Clinically Relevant Pharmacodynamic Interactions Between Antiepileptic Drugs and Psychotropic Drugs: An Update


Edoardo Spina* and Jose de Leon


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Current and Emerging Strategies in Osteoporosis Management


Stefka Ivanova and Liliya Vasileva*


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New Strategies for the Prevention and Treatment of Systemic and Local Bone Loss; from Pathophysiology to Clinical Application


A. Fassio, Maurizio Rossini , Ombretta Viapiana, Luca Idolazzi, Camilla Benini, Elisabetta Vantaggiato and Davide Gatti


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Recent Advances in Polymeric Nanosystems for Treating Cutaneous Melanoma and Its Metastasis


Yi-Ping Chou, Yin-Ku Lin, Chun-Han Chen and Jia-You Fang*


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Potential Application of 5-Aryl-Substituted 2-Amino-benzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals


Shinichi Uesato, Yoshiyuki Hirata and Tsutomu Sasaki


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Antidiabetic Drugs and the Kidney


Moses Elisaf, Eleftheria Tzavela, Nikolaos Karanatsis and Vasilis Tsimihodimos


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Post Mortem Redistribution of Drugs: Current State of Knowledge


Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti and Anne-Laure Pelissier-Alicot*


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Effect and Mechanism of Curcumin on EZH2 – miR-101 Regulatory Feedback Loop in Multiple Myeloma


Chuanqing Wu, Tuo Ruan, Weizhen Liu, Xiaojie Zhu, Juan Pan, Wen Lu, Chen Yan, Kaixiong Tao , Weikang Zhang* and Chun Zhang*


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Application of Bone Marrow Stem Cell Based Therapy in Bone Loss Diseases


Nan Xiao*


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Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications


Sally Sabra, Mona Abdelmoneem, Mahmoud Abdelwakil, Moustafa Taha Mabrouk, Doaa Anwar, Rania Mohamed, Sherine Khattab, Adnan Bekhit, Kadria Elkhodairy, May Freag and Ahmed Elzoghby*


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Bone-Muscle Crosstalk: Unraveling New Therapeutic Targets for Osteoporosis


Anna Picca, Riccardo Calvani*, Ester Manes-Gravina, Leonardo Spaziani, Francesco Landi, Roberto Bernabei and Emanuele Marzetti


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Hyaluronate-Lipid Nanohybrids: Fruitful Harmony in Cancer Targeting


May S Freag*


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Micelles As Delivery System for Cancer Treatment


Dilek Keskin and Ayşen Tezcaner*


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Ligand-modified Biopolymeric Nanoparticles as Efficient Tools for Targeted Cancer Therapy


Hasan Kouchakzadeh*, Tooba Soudi, Niloofar Heshmati Aghda and Seyed Abbas Shojaosadati


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Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds


Maria Yanez, James Blanchette and Ehsan Jabbarzadeh*


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Pharmacological Treatment of Bone Loss


Rui Pang and Weibo Xia*


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‘Osteoimmunology’ Offers New Perspectives for the Treatment of Pathological Bone Loss


Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li and Jie Guo*


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Prospect of Combination and Sequential Therapies for Postmenopausal Osteoporosis


Hao Liu and Binbin Li*


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Global Effects Of Early Life Stress On Neurons And Glial Cells


Dueñas Zulma, Caicedo-Mera Juan Carlos and Torner Luz


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Natural Approaches in Diabetes Management: A Review of Diet, Exercise, and Natural Products


William M. Schultz, Tina Varghese, Robert E. Hein, Devinder S. Dhindsa, Elliot N. Mahlof, Hannah C. Cai, Geoffrey Southmayd, Pratik B. Sandesaraa, Danny J. Eapen and Laurence S. Sperling


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