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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 19, 18 Issues, 2019
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Ranking and Category

  • 39th of 61 in

    Chemistry, Medicinal

  • 172nd of 229 in

    Oncology

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Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 19

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Number 10



Biography   Open Access



Review Article



Review Article



Review Article



Research Article



Research Article



Research Article



Research Article

Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools

, 19(10): 1262 - 1275

Lurdes Gano, Teresa Pinheiro, António P. Matos, Francisco Tortosa, Tiago F. Jorge, Maria S. Gonçalves, Marta Martins, Tânia S. Morais, Andreia Valente, Ana I. Tomaz, Maria H. Garcia and Fernanda Marques*


DOI: 10.2174/1871520619666190318152726


Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 14


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 13


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 12


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 11


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print







Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma


Nooshin Mohtasham, Hossein Ayatollahi, Nasrollah Saghravanian, Reza Zare, Mohammad-Taghi Shakeri, Amirhossein Sahebkar* and Farnaz Mohajertehran*


DOI: 10.2174/1871520619666191014160818
View Abstract View on PubMed





Abstracts Ahead of Print


The Role of PGC-1α in Digestive System Malignant Tumours


Qiushuang Zhang, Wei Chen, Chao Xie, Xiaoshuo Dai, Junfen Ma and Jing Lu*


DOI: 10.2174/1871520619666191105125409
View Abstract


Evaluation OF Potential Cytotoxic Effect of Different Proton Pump Inhibitors on Different Human Cancer Cell Lines


Aya Qasem, Violet Kasabri*, Eman AbuRish, Yasser Bustanji, Yusuf Al-Hiari, Reem AlAbbasi, Bashaer AbuRmilha and Sundus Alalawi


DOI: 10.2174/1871520619666191029151545
View Abstract


Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics


Ponnurengam Malliappan Sivakumar, Matin Islami, Ali Zarrabi*, Arezoo Khosravi and Shohreh Peimanfard


DOI: 10.2174/1871520619666191028112258
View Abstract



Coumarin- Fatty Acid Conjugates as Potential ERα/AKT-1 Antagonists for ER Positive Breast Cancer


Jubie Selvaraj*, Jameera B.A. John, Nanjan M. Joghee, Justin Antony, Ashish Wadhwani and Jawahar Natarajan


DOI: 10.2174/1871520619666191028104339
View Abstract


Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents


Leonard Barasa, Hari P. Vemana, Nirupama Surubhotla, Sin S. Ha, Jing Kong, Alison Yong, John L. Croft, Vikas V. Dukhande and Sabesan Yoganathan*


DOI: 10.2174/1871520619666191028101506
View Abstract


High Expression of SIRT1 Associates with the Doxorubicin Resistance of Breast Cancer through Activating of Akt


Xiaoxia Jin, Yingze Wei, Yushan Liu, Yali Chen, Bin Zhao, Jieyu Huang, Haiyan Yu and Chunsun Li*


DOI: 10.2174/1871520619666191028100405
View Abstract


Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives


Liliana Silva, Pedro Coelho, Dulce Teixeira, Armanda Monteiro, Gabriela Pinto, Raquel Soares, Cristina Prudêncio and Mónica Vieira*


DOI: 10.2174/1871520619666191028091547
View Abstract


Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer


Mohamed A. Tantawy, Farid M. Sroor*, Magda F. Mohamed*, Mostafa E. El-Naggar, Fatma M. Saleh, Hamdi M. Hassaneen and Ismail A. Abdelhamid*


DOI: 10.2174/1871520619666191024121116
View Abstract


Published Contents

Editor's Choice

Synthesis, Spectroscopic Properties, Crystal Structure And Biological Evaluation of New Platinum Complexes with 5-methyl-5-(2-thiomethyl)ethyl Hydantoin

, 2019; 19(10): 1243 - 1252

Adriana G. Bakalova*, Rossen T. Buyukliev, Rositsa P. Nikolova, Boris L. Shivachev, Rositsa A. Mihaylova and Spiro M. Konstantinov


DOI: 10.2174/1871520619666190214103345





Synthesis of New Dihydroquinopimaric Acid Analogs with Nitrile Groups as Apoptosis-Inducing Anticancer Agents

, 2019; 19(9): 1172 - 1183

Elena V. Tretyakova*, Elena V. Salimova, Lyudmila V. Parfenova, Milyausha M. Yunusbaeva, Lilya U. Dzhemileva, Vladimir A. D’yakonov and Usein M. Dzhemilev


DOI: 10.2174/1871520619666190404100846




2,4-Disubstituted Quinazoline Derivatives Act as Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity

, 2019; 19(8): 1048 - 1057

Ebrahim S. Moghadam, Maryam H. Tehrani, René Csuk, Lucie Fischer, Mohammad Ali Faramarzi, Arezoo Rashidi, Iraj Javadi and Mohsen Amini*


DOI: 10.2174/1871520619666190314125254




Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting the GPER

, 2019; 19(6): 760 - 771

Oscar J. Zacarías-Lara, David Méndez-Luna, Gustavo Martínez-Ruíz, José R. García-Sanchéz, Manuel J. Fragoso-Vázquez*, Martiniano Bello, Elvia Becerra-Martínez, Juan B. García-Vázquez and José Correa-Basurto*


DOI: 10.2174/1871520618666181119094144



Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities

, 2019; 19(5): 697 - 706

Hany A.M. El-Sherief, Bahaa G.M. Youssif*, Ahmed H. Abdelazeem, Mohamed Abdel-Aziz and Hamdy M. Abdel-Rahman*


DOI: 10.2174/1871520619666181224115346



A New Synthetic Spiroketal: Studies on Antitumor Activity on Murine Melanoma Model In Vivo and Mechanism of Action In Vitro

, 2019; 19(4): 567 - 578

Maria P. Fuggetta*, Pietro Spanu*, Fausta Ulgheri, Francesco Deligia, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona and Franco Morelli*


DOI: 10.2174/1871520619666190131141400



Open Access Articles


New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang





Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi






Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

, 2014; 14(8): 1121 - 1127

Bryan Oronsky, Neil Oronsky, Susan Knox, Gary Fanger and Jan Scicinski




Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

, 2014; 14(6): 840 - 851

Georgina A. Cardama, Maria J. Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe, Adrian G. Turjanski, Daniel F. Alonso, Daniel E. Gomez and Pablo Lorenzano Menna




β2-Microglobulin-mediated Signaling as a Target for Cancer Therapy

, 2014; 14(3): 343 - 352

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Sajni Josson, Hiromitsu Mimata and Leland W. K. Chung






Most Cited Articles

Review Article

Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: A key review

, 2018; 18(4): 488-505.

K. P. Rakesh, Shi-Meng Wang, Jing Leng, L. Ravindar, Abdullah M. Asiri, Hadi M. Marwani and Hua-Li Qin*


DOI: 10.2174/1871520617666171103140749




Research Article

Effects of plasma activated medium on head and neck fadu cancerous cells: Comparison of 3D and 2D response

, 2018; 18(6): 776-783.

Julie Chauvin, Florian Judee, Nofel Merbahi* and Patricia Vicendo


DOI: 10.2174/1871520617666170801111055


Research Article

Genistein induces alterations of epigenetic modulatory signatures in human cervical cancer cells

, 2018; 18(3): 412-421.

Madhumitha Kedhari Sundaram, Mohammad Zeeshan Ansari, Abdullah Al Mutery, Maryam Ashraf, Reem Nasab, Sheethal Rai, Naushad Rais and Arif Hussain*


DOI: 10.2174/1871520617666170918142114


Research Article

Design and discovery of novel quinoxaline derivatives as dual DNA intercalators and topoisomerase II inhibitors

, 2018; 18(2): 195-209.

Ibrahim H. Eissa, Abeer M. El-Naggar*, Nour E.A. Abd El-Sattar and Ahmed S.A. Youssef


DOI: 10.2174/1871520617666170710182405




General Research Article

Ros-scavenging and anti-tyrosinase properties of crocetin on B16F10 murine melanoma cells

, 2018; 18(7): 1064-1069.

Seyed H. Hashemi-Shahri, Alireza Golshan, Seyed A. Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar and Zahra Tayarani-Najaran*


DOI: 10.2174/1871520618666171213143455



Review Article

Critical microRNAs in lung cancer: Recent advances and potential applications

, 2018; 18(14): 1991-2005.

Habib Zarredar, Khalil Ansarin, Behzad Baradaran, Najibeh Shekari, Shirin Eyvazi , Fateme Safari and Safar Farajnia*


DOI: 10.2174/1871520618666180808125459


Research Article

Cold physical plasma-treated buffered saline solution as effective agent against pancreatic cancer cells

, 2018; 18(6): 824-831.

Sander Bekeschus*, André Käding, Tim Schröder, Kristian Wende, Christine Hackbarth, Kim R. Liedtke, Julia van der Linde, Thomas von Woedtke, Claus-Dieter Heidecke and Lars-Ivo Partecke


DOI: 10.2174/1871520618666180507130243


Research Article

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

, 2018; 18(2): 263-276.

Dima A. Sabbah*, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Haizhen A. Zhong, Reema Abu Khalaf, Ameerah (Hasan Ibrahim), Tariq Al-Qirim, Ghassan Abu Sheikha and Mohammad S. Mubarak


DOI: 10.2174/1871520617666170911171152


Review Article

Tumor-targeting peptides: Ligands for molecular imaging and therapy

, 2018; 18(1): 74-86.

Ning Zhao, Yeshan Qin, Hongguang Liu* and Zhen Cheng*


DOI: 10.2174/1871520617666170419143459




Most Accessed Articles


Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik


DOI: 10.2174/1871520619666181207094243












Editor-in-Chief

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

Biography View Full Editorial Board

Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.
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Scopus CiteScore Metrics: 1.76


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