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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 19, 18 Issues, 2019
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Ranking and Category

  • 39th of 61 in

    Chemistry, Medicinal

  • 172nd of 229 in

    Oncology

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Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 19

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Number 8



Biography   Open Access



Review Article



Review Article



Research Article



Research Article

Two Novel Tri-Aryl Derivatives Attenuate the Invasion-Promoting Effects of Stromal Mesenchymal Stem Cells on Breast Cancer

, 19(8): 1002 - 1011

Khadijeh Moradi, Farnaz Barneh, Saeed Irian, Mohsen Amini, Raheleh Moradpoor, Amir Amanzadeh, Samira Choopani, Hamzeh Rahimi, Tayebeh Ghodselahi, Massoud M. Boujar and Mona Salimi*


DOI: 10.2174/1871520619666190212123912


Research Article



Research Article



Research Article



Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

New Derivatives of Bacteriopurpurin with Thiolated Au (I) Complexes: Dual Darkand Light Activated Antitumor Potency


Mikhail A. Grin*, Sergei I. Tikhonov, Albina S. Petrova, Victor A. Pogorilyy, Аlexey N. Noev, Victor V. Tatarskiy, Dmitry B. Shpakovsky, Elena R. Milaeva, Elena V. Kalinina, Nikolai N. Chernov, Аlexander А. Shtil, Andrei F. Mironov, Andrei D. Kaprin and Elena V. Filonenko


DOI: 10.2174/1871520619666190801102617
View Abstract View on PubMed


Celastrus Orbiculatus Extracts Inhibit the Metastasis through Attenuating PI3K/Akt/mTOR Signaling Pathway in Human Gastric Cancer


Yayun Qian, Yan Yan, Hongmei Lu, Tingting Zhou, Mengying Lv, Chuanci Fang, Jingjing Hou, Wenyuan Li, Xiwen Chen, Hui Sun, Yajuan Li, Zheng Wang, Nan Zhao, Yajuan Gu, Yongling Ding* and Yanqing Liu*


DOI: 10.2174/1871520619666190731162722
View Abstract View on PubMed



Design, In Silico Modelling, and Functionality Theory of Novel Folate Receptor Targeted Rutin Encapsulated Folic Acid Conjugated Keratin Nanoparticles for Effective Cancer Treatment


Selvaraj Kunjiappan, Theivendren Panneerselvam*, Saravanan Govindaraj, Pavadai Parasuraman, Suraj Baskararaj, Murugesan Sankaranarayanan, Sankarganesh Arunachalam, Ewa Babkiewicz, Aarthi Jeyakumar and Muthulakshmi Lakshmanan


DOI: 10.2174/1871520619666190702145609
View Abstract View on PubMed







The Effect of a Ferrocene Containing Camphor Sulfonamide DK-164 on Breast Cancer Cell Lines


Maria Schröder, Shazie Yusein-Myashkova, Maria Petrova, Georgi Dobrikov, Mariana Kamenova-Nacheva, Jordana Todorova, Evdokia Pasheva and Iva Ugrinova


DOI: 10.2174/1871520619666190724094334
View Abstract View on PubMed


Abstracts Ahead of Print

Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy


Ponnurengam Malliappan Sivakumar, Shohreh Peimanfard, Ali Zarrabi*, Arezoo Khosravi and Matin Islami


DOI: 10.2174/1871520619666190906160359
View Abstract






Synthesis and Anticancer Activity of Benzimidazole/Benzoxazole Substituted Triazolotriazines in Hepatocellular Carcinoma


Sakineh Dadashpour, Tuba T. Küçükkılınç, Ayse Ercan, Seyed J. Hosseinimehr, Nima Naderi and Hamid Irannejad*


DOI: 10.2174/1871520619666190808152051
View Abstract



Jab1-siRNA Induces Cell Growth Inhibition and Cell Cycle Arrest in Gall Bladder Cancer Cells via Targeting Jab1 Signalosome


Pratibha Pandey, Mohammad H. Siddiqui, Anu Behari, V.K. Kapoor, Kumudesh Mishra, Uzma Sayyed, Rohit K. Tiwari, Rafia Shekh and Preeti Bajpai*


DOI: 10.2174/1871520619666190725122400
View Abstract


Lemon Juice Mediated Synthesis Of 3-Substituted Quinazolin-4(3H)-Ones and their Pharmacological Evaluation


Malavattu G. Prasad, C. Vijaya Lakshmi, Naresh K. Katari*, Rajshekhar Karpoormath and Manojit Pal


DOI: 10.2174/1871520619666190723151909
View Abstract



Published Contents

Editor's Choice

2,4-Disubstituted Quinazoline Derivatives Act as Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity

, 2019; 19(8): 1048 - 1057

Ebrahim S. Moghadam, Maryam H. Tehrani, René Csuk, Lucie Fischer, Mohammad Ali Faramarzi, Arezoo Rashidi, Iraj Javadi and Mohsen Amini*


DOI: 10.2174/1871520619666190314125254




Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting the GPER

, 2019; 19(6): 760 - 771

Oscar J. Zacarías-Lara, David Méndez-Luna, Gustavo Martínez-Ruíz, José R. García-Sanchéz, Manuel J. Fragoso-Vázquez*, Martiniano Bello, Elvia Becerra-Martínez, Juan B. García-Vázquez and José Correa-Basurto*


DOI: 10.2174/1871520618666181119094144



Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities

, 2019; 19(5): 697 - 706

Hany A.M. El-Sherief, Bahaa G.M. Youssif*, Ahmed H. Abdelazeem, Mohamed Abdel-Aziz and Hamdy M. Abdel-Rahman*


DOI: 10.2174/1871520619666181224115346



A New Synthetic Spiroketal: Studies on Antitumor Activity on Murine Melanoma Model In Vivo and Mechanism of Action In Vitro

, 2019; 19(4): 567 - 578

Maria P. Fuggetta*, Pietro Spanu*, Fausta Ulgheri, Francesco Deligia, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona and Franco Morelli*


DOI: 10.2174/1871520619666190131141400



Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase

, 2019; 19(3): 375 - 388

Karolina Królewska-Golińska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrańska and Barbara Nawrot


DOI: 10.2174/1871520619666181122123552



Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines

, 2019; 19(3): 410 - 424

Anuka S. Mendis*, Ira Thabrew, Meran K. Ediriweera, Sameera R. Samarakoon, Kamani H. Tennekoon, Achyut Adhikari* and Egodage D. de Silva


DOI: 10.2174/1871520619666181128163359




Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells

, 2019; 19(1): 112 - 120

José C. Quilles Jr, Murillo D.L. Bernardi, Pedro H.J. Batista, Samelyn C.M. Silva, Camila M.R. Rocha, Carlos A. Montanari and Andrei Leitão*


DOI: 10.2174/1871520618666181029141649



Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention

, 2019; 19(1): 38 - 47

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*


DOI: 10.2174/1871520619666181231112453



Open Access Articles


New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi






Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

, 2014; 14(8): 1121 - 1127

Bryan Oronsky, Neil Oronsky, Susan Knox, Gary Fanger and Jan Scicinski




Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

, 2014; 14(6): 840 - 851

Georgina A. Cardama, Maria J. Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe, Adrian G. Turjanski, Daniel F. Alonso, Daniel E. Gomez and Pablo Lorenzano Menna




β2-Microglobulin-mediated Signaling as a Target for Cancer Therapy

, 2014; 14(3): 343 - 352

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Sajni Josson, Hiromitsu Mimata and Leland W. K. Chung





Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells

, 2014; 14(1): 170 - 180

Sunil Sagar, Luke Esau, Basem Moosa, Niveen M. Khashab, Vladimir B. Bajic and Mandeep Kaur





Most Cited Articles

Review Article

Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: A key review

, 2018; 18(4): 488-505.

K. P. Rakesh, Shi-Meng Wang, Jing Leng, L. Ravindar, Abdullah M. Asiri, Hadi M. Marwani and Hua-Li Qin*


DOI: 10.2174/1871520617666171103140749




Research Article

Genistein induces alterations of epigenetic modulatory signatures in human cervical cancer cells

, 2018; 18(3): 412-421.

Madhumitha Kedhari Sundaram, Mohammad Zeeshan Ansari, Abdullah Al Mutery, Maryam Ashraf, Reem Nasab, Sheethal Rai, Naushad Rais and Arif Hussain*


DOI: 10.2174/1871520617666170918142114


Research Article

Design and discovery of novel quinoxaline derivatives as dual DNA intercalators and topoisomerase II inhibitors

, 2018; 18(2): 195-209.

Ibrahim H. Eissa, Abeer M. El-Naggar*, Nour E.A. Abd El-Sattar and Ahmed S.A. Youssef


DOI: 10.2174/1871520617666170710182405


Research Article

Effects of plasma activated medium on head and neck fadu cancerous cells: Comparison of 3D and 2D response

, 2018; 18(6): 776-783.

Julie Chauvin, Florian Judee, Nofel Merbahi* and Patricia Vicendo


DOI: 10.2174/1871520617666170801111055



Review Article

Critical microRNAs in lung cancer: Recent advances and potential applications

, 2018; 18(14): 1991-2005.

Habib Zarredar, Khalil Ansarin, Behzad Baradaran, Najibeh Shekari, Shirin Eyvazi , Fateme Safari and Safar Farajnia*


DOI: 10.2174/1871520618666180808125459


General Research Article

Ros-scavenging and anti-tyrosinase properties of crocetin on B16F10 murine melanoma cells

, 2018; 18(7): 1064-1069.

Seyed H. Hashemi-Shahri, Alireza Golshan, Seyed A. Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar and Zahra Tayarani-Najaran*


DOI: 10.2174/1871520618666171213143455


Research Article

Cold physical plasma-treated buffered saline solution as effective agent against pancreatic cancer cells

, 2018; 18(6): 824-831.

Sander Bekeschus*, André Käding, Tim Schröder, Kristian Wende, Christine Hackbarth, Kim R. Liedtke, Julia van der Linde, Thomas von Woedtke, Claus-Dieter Heidecke and Lars-Ivo Partecke


DOI: 10.2174/1871520618666180507130243


Research Article

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

, 2018; 18(2): 263-276.

Dima A. Sabbah*, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Haizhen A. Zhong, Reema Abu Khalaf, Ameerah (Hasan Ibrahim), Tariq Al-Qirim, Ghassan Abu Sheikha and Mohammad S. Mubarak


DOI: 10.2174/1871520617666170911171152



General Review Article

Coumarin derivatives as anticancer agents for lung cancer therapy: A review

, 2018; 18(7): 964-984.

Manvendra Kumar, Ramit Singla, Jyoti Dandriyal and Vikas Jaitak*


DOI: 10.2174/1871520618666171229185926





Most Accessed Articles



Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik


DOI: 10.2174/1871520619666181207094243







Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells

, 2019; 19(1): 112-120.

José C. Quilles Jr, Murillo D.L. Bernardi, Pedro H.J. Batista, Samelyn C.M. Silva, Camila M.R. Rocha, Carlos A. Montanari and Andrei Leitão*


DOI: 10.2174/1871520618666181029141649





Editor-in-Chief

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

Biography View Full Editorial Board

Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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