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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 21, 18 Issues, 2021
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 21

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Number 9









Research Article

New Hybrid Scaffolds Based on Carbazole-Chalcones as Potent Anticancer Agents

, 21(9): 1082 - 1091

Faisal Rashid, Sumera Zaib, Aliya Ibrar*, Syeda A. Ejaz, Aamer Saeed, Jamshed Iqbal* and Imtiaz Khan*


DOI: 10.2174/1871520620666200721110732




Research Article

A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors

, 21(9): 1099 - 1109

Ebru Zeytün, Mehlika D. Altıntop*, Belgin Sever, Ahmet Özdemir, Doha E. Ellakwa, Zeynep Ocak, Halil I. Ciftci, Masami Otsuka, Mikako Fujita* and Mohamed O. Radwan*


DOI: 10.2174/1871520620666200824100408


Research Article

Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate

, 21(9): 1110 - 1119

Huiping Ling, Hong Li, Meijun Chen, Baolong Lai, Haiming Zhou, Hui Gao, Jiangye Zhang, Yan Huang* and Yiwen Tao*


DOI: 10.2174/1871520620666200408080040




Anti-Cancer Agents in Medicinal Chemistry, Volume 21 (2021) - Number 13


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 21 (2021) - Number 12


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 21 (2021) - Number 11


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 21 (2021) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential


Hardeep S. Tuli*, Vaishali Aggarwal, Gaurav Parashar, Diwakar Aggarwal, Nidarshana C. Parashar, Muobarak J. Tuorkey, Mehmet Varol, Katrin Sak, Manoj Kumar and Harpal S. Buttar


DOI: 10.2174/1871520621666210223095021
View Abstract View on PubMed



Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improves Chemotherapy Activity in Prostate Cancer Cells


Lucas F. Gomes, Pâmela J.H. Longhi, Larissa Machado, Ivana B. Mânica da Cruz, Marco A.E. Montano, Mathias Martins, Sérgio A. Machado, Jovani A. Steffani and Francine C. Cadoná*


DOI: 10.2174/1871520621666210112111711
View Abstract View on PubMed








Emerging Molecular Functions of MicroRNA-9: Cancer Pathology and Therapeutic Implications


Behnam E.G. Tapeh , Bashir Mosayyebi, Behzad Mansoori , Zahra A. Gravand, Hamzeh Sarvnaz and Ali Mohammadi *


DOI: 10.2174/1871520621666210217094839
View Abstract View on PubMed


Abstracts Ahead of Print

Propolis Extract Regulate microRNA Expression in Glioblastoma and Brain Cancer Stem Cells


Ugur C. Yilmaz, Bakiye G. Bagca*, Emin Karaca, Asude Durmaz, Burak Durmaz, Ayca Aykut, Husniye Kayalar, Cigir B. Avci, Sunde Y. Susluer, Erhan Pariltay, Cumhur Gunduz and Ozgur Cogulu


DOI: 10.2174/1871520621666210504082528
View Abstract





Diagnostic and Therapeutic Applications of Exosome Nanovesicles in Lung Cancer: State-of-The-Art


Rezvan Mohammadi, Seyede A. Hosseini, Somaye Noruzi, Ailin Ebrahimzadeh and Amirhossein Sahebkar*


DOI: 10.2174/1871520621666210301085318
View Abstract


Radioprotective Role of Natural Polyphenols: From Sources to Mechanisms


Muhammad Adnan, Azhar Rasul, Muhammad A. Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaza, Iqra Sarfraza, Arif Hussaina, Khatereh Khorsandid, Ngit S. Laie and Syed M. Hussaina*


DOI: 10.2174/1871520621666210419095829
View Abstract


Prospects of Delivering Natural Compounds by Polymer-Drug Conjugates in Cancer Therapeutics


Nompumelelo P. Mthimkhulu, Karabo S. Mosiane, Ekene E. Nweke, Mohammed Balogun and Pascaline Fru*


DOI: 10.2174/1871520621666210419094623
View Abstract


Hindering The Synchronization Between Mir-486-5p And H19 Lncrna By Hesperetin Halts Breast Cancer Aggressiveness Through Tuning ICAM-1


Ramah M. Abdallah , Aisha M. Elkhouly , Raghda A. Soliman , Nahed El Meckawy , Ahmed El Sebaei , Amira A. Motaal , Hesham El-Askary , Rana A. Youness * and Reem A. Assal *


DOI: 10.2174/1871520621666210419093652
View Abstract


Evaluation of Benzamide-chalcone Derivatives as EGFR/CDK2 inhibitor: Synthesis, in-vitro Inhibition, and Molecular Modeling Studies


Akshada Joshi, Heena Bhojwani, Ojas Wagal, Khushboo Begwani, Urmila Joshi*, Sadhana Sathaye and Divya Kanchan


DOI: 10.2174/1871520621666210415091359
View Abstract


Effects of Sambucus Ebulus Extract on Cell Proliferation and Viability of Triple-Negative Breast Cancer: An In Vitro and In Vivo Study


Vahid F. Omrani, Ameneh Koochaki , Sahar Behzad , Vahid Kia, Peyman Ghasemi, Javad Razaviyan , Hamid Reza Moosavian , Maysam Rezapour , Mohammad Vasei , Mohsen Asouri and Samira Mohammadi-Yeganeh *


DOI: 10.2174/1871520621666210412113944
View Abstract


Published Contents

Editor's Choice

On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids against Breast Tumor Cells (MDA-231 and MCF-7)

, 2021; 21(9): 1172 - 1182

Celisnolia M. Leite*, João Honorato de Araujo-Neto, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista*


DOI: 10.2174/1871520620666200824114816



Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives

, 2021; 21(8): 963 - 986

Samir M. Awad, Mosaad S. Mohamed, Marwa Abd El-Fattah Khodair and Rania H. Abd El-Hameed*


DOI: 10.2174/1871520620666200925103742




Novel Dihydropyrimidinone-Derived Selenoesters as Potential Cytotoxic Agents to Human Hepatocellular Carcinoma: Molecular Docking and DNA Fragmentation

, 2021; 21(6): 703 - 715

Jean C. Benassi, Flavio A.R. Barbosa, Valdelúcia M.A.S. Grinevicius, Fabiana Ourique, Daniela Coelho, Karina B. Felipe, Antônio L. Braga, Danilo W. Filho and Rozangela C. Pedrosa*


DOI: 10.2174/1871520620666200728124640



Anticancer Active Heterocyclic Chalcones: Recent Developments

, 2021; 21(5): 558 - 566

Prasad Dandawate, Khursheed Ahmed, Subhash Padhye, Aamir Ahmad* and Bernhard Biersack*


DOI: 10.2174/1871520620666200705215722



Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid

, 2021; 21(4): 462 - 467

Agnieszka Siebert, Milena Deptuła, Mirosława Cichorek, Anna Ronowska, Grzegorz Cholewiński* and Janusz Rachon


DOI: 10.2174/1871520620666200516151456



Benzimidazole Derivative Ameliorates Opioid-Mediated Tolerance during Anticancer- Induced Neuropathic Pain in Mice

, 2021; 21(3): 365 - 371

Sana Akhtar, Muzaffar Abbas*, Komal Naeem, Muhammad Faheem, Humaira Nadeem and Amber Mehmood


DOI: 10.2174/1871520620999200818155031




Therapy Resistance in Cancers: Phenotypic, Metabolic, Epigenetic and Tumour Microenvironmental Perspectives

, 2020; 20(18): 2190 - 2206

Tasnim Zahan, Plabon K. Das, Syeda F. Akter, Rowshanul Habib, Md. Habibur Rahman, Md. Rezaul Karim* and Farhadul Islam*


DOI: 10.2174/1871520620999200730161829




Open Access Articles


The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner

, 2020; 20(13): 1613 - 1625

Joseph Mazar*, Caleb Gordon, Varun Naga and Tamarah J. Westmoreland




Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells

, 2020; 20(6): 687 - 699

Gongshen Jin*, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang and Hao Zhang





Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*





New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi







Most Cited Articles


Review Article

Cdk1 in breast cancer: Implications for theranostic potential

, 2020; 20(7): 758-767.

Sepideh Izadi, Afshin Nikkhoo, Mohammad Hojjat-Farsangi, Afshin Namdar, Gholamreza Azizi, Hamed Mohammadi, Mehdi Yousefi and Farhad Jadidi-Niaragh*


DOI: 10.2174/1871520620666200203125712



Research Article

Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer

, 2020; 20(1): 70-83.

Mohamed A. Tantawy, Farid M. Sroor*, Magda F. Mohamed*, Mostafa E. El-Naggar, Fatma M. Saleh, Hamdi M. Hassaneen and Ismail A. Abdelhamid*


DOI: 10.2174/1871520619666191024121116


Review Article

Nitrogen-containing heterocycles as anticancer agents: An overview

, 2020; 20(18): 2150-2168.

Damanpreet K. Lang, Rajwinder Kaur*, Rashmi Arora, Balraj Saini and Sandeep Arora


DOI: 10.2174/1871520620666200705214917


Review Article

Recent advances of silver nanoparticles in cancer diagnosis and treatment

, 2020; 20(11): 1276-1287.

Tran Q. Huy*, Pham T.M. Huyen, Anh-Tuan Le and Matteo Tonezzer*


DOI: 10.2174/1871520619666190710121727


Research Article

Beta-caryophyllene suppresses ovarian cancer proliferation by inducing cell cycle arrest and apoptosis

, 2020; 20(13): 1530-1537.

Santhosh Arul, Harinee Rajagopalan, Jivitesh Ravi and Haripriya Dayalan*


DOI: 10.2174/1871520620666200227093216


Research Article

Synthesis, anticancer, and antibacterial activity of betulinic and betulonic acid C-28-triphenylphosphonium conjugates with variable alkyl linker length

, 2020; 20(3): 286-300.

Olga V. Tsepaeva, Andrey V. Nemtarev*, Taliya I. Salikhova, Timur I. Abdullin, Leysan R. Grigor`eva, Svetlana A. Khozyainova and Vladimir F. Mironov


DOI: 10.2174/1871520619666191014153554



Review Article

Nanoformulations of coumarins and the hybrid molecules of coumarins with potential anticancer effects

, 2020; 20(15): 1797-1816.

Mukerrem Betul Yerer*, Serkan Dayan, M. Ihsan Han, Ajay Sharma, Hardeep S. Tuli and Katrin Sak


DOI: 10.2174/1871520620666200310094646



General Research Article

Quercetin-mediated apoptosis and cellular senescence in human colon cancer

, 2020; 20(11): 1387-1396.

Serpil Özsoy*, Eda Becer, Hilal Kabadayı, Hafize S. Vatansever and Sevinç Yücecan


DOI: 10.2174/1871520620666200408082026


Research Article

Ruxolitinib regulates the autophagy machinery in multiple myeloma cells

, 2020; 20(18): 2316-2323.

Alican Kusoglu*, Bakiye G. Bagca, Neslihan P.O. Ay, Guray Saydam and Cigir B. Avci


DOI: 10.2174/1871520620666200218105159


Research Article

Resveratrol counteracts hypoxia-induced gastric cancer invasion and emt through hedgehog pathway suppression

, 2020; 20(9): 1105-1114.

Qin-Hong Xu, Ying Xiao, Xu-Qi Li*, Lin Fan*, Can-Can Zhou, Liang Cheng, Zheng-Dong Jiang and Guang-Hui Wang


DOI: 10.2174/1871520620666200402080034


Research Article

Apoptotic effects of melittin on 4t1 breast cancer cell line is associated with up regulation of mfn1 and drp1 mrna expression

, 2020; 20(7): 790-799.

Farnaz D. Moghaddam, Pejman Mortazavi*, Somayeh Hamedi, Mohammad Nabiuni and Nasim H. Roodbari


DOI: 10.2174/1871520620666200211091451



Most Accessed Articles

Effect of Dasatinib on Genes Related to Mitotic Catastrophe Pathway in Chronic Myeloid Leukemia Cells

, 2021; 21(13): 1724-1731.

Sezgi Kipcak, Buket Ozel, Cigir Biray Avci*, Leila S. Takanlou, Maryam S. Takanlou, Cumhur Gunduz and Nur Selvi Gunel


DOI: 10.2174/1871520620666201106085929



Chalcone Scaffolds as Anticancer Drugs: A Review on Molecular Insight in Action of Mechanisms and Anticancer Properties

, 2021; 21(13): 1650-1670.

Shefali Shukla, Anantpreet K. Sood, Kartika Goyal, Ambika Singh, Vaidehi Sharma, Neha Guliya, Shikha Gulati and Sanjay Kumar*


DOI: 10.2174/1871520620999201124212840



Synthesis, Molecular Docking and Biological Activity Evaluation of Alkoxy Substituted Chalcone Derivatives: Potential Apoptosis Inducing Agent on MCF-7 Cells

, 2021; 21(13): 1738-1750.

Wan M. Khairul*, Fatimah Hashim*, Mas Mohammed, Nurul Shazwani Mohd Norhadi Shah, Syed Ahmad Tajudin Tuan Johari, Rafizah Rahamathullah, Adibah Izzati Daud and Nyuk Ling Ma


DOI: 10.2174/1871520620999201110190709


Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds

, 2021; 21(13): 1717-1723.

Kruti A. Mehta, Kinjal A. Patel, Ajai B. Kunnumakkara and Prabhudas S. Patel*


DOI: 10.2174/1871520620999201124213259






The Potential Clinical Value of Curcumin and its Derivatives in Colorectal Cancer

, 2021; 21(13): 1626-1637.

Zhaoying Yao, Thi Ha Le, Qianming Du, Huiwen Mu, Chao Liu* and Yubing Zhu*


DOI: 10.2174/1871520620999201113095821








Editor-in-Chief

graphic
Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Chieti
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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