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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 20, 18 Issues, 2020
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Ranking and Category

  • 39th of 61 in

    Chemistry, Medicinal

  • 172nd of 229 in

    Oncology

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Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 19

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Number 17



Biography   Open Access



Review Article



Review Article



Research Article



Research Article

Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma

, 19(17): 2072 - 2078

Nooshin Mohtasham, Hossein Ayatollahi, Nasrollah Saghravanian, Reza Zare, Mohammad-Taghi Shakeri, Amirhossein Sahebkar* and Farnaz Mohajertehran*


DOI: 10.2174/1871520619666191014160818


Research Article

The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1)

, 19(17): 2079 - 2090

Anna Leja-Szpak*, Marta Góralska, Paweł Link-Lenczowski, Urszula Czech, Katarzyna Nawrot-Porąbka, Joanna Bonior and Jolanta Jaworek


DOI: 10.2174/1871520619666190415165212


Research Article   Open Access



Research Article

The Correlation between EGFR and Androgen Receptor Pathways: A Novel Potential Prognostic Marker in Gastric Cancer

, 19(17): 2097 - 2107

Shahrzad S. Fard, Kioomars Saliminejad, Masoud Sotoudeh, Niloofar Soleimanifard, Shaghayegh Kouchaki, Mansour Yazdanbod, Habibollah Mahmoodzadeh, Ardeshir Ghavamzadeh, Reza Malekzadeh, Bahram Chahardouli, Kamran Alimoghaddam* and Seyed H. Ghaffari*


DOI: 10.2174/1871520619666190930142820


Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 18


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print







Anticancer Potential of Dietary Natural Products: A Comprehensive Review


Rumana Ahmad*, Mohsin A. Khan, A.N. Srivastava, Anamika Gupta, Aditi Srivastava, Tanvir R. Jafri, Zainab Siddiqui, Sunaina Chaubey, Tahmeena Khan and Arvind K. Srivastava


DOI: 10.2174/1871520619666191015103712
View Abstract View on PubMed


Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents


Leonard Barasa, Hari P. Vemana, Nirupama Surubhotla, Sin S. Ha, Jing Kong, Alison Yong, John L. Croft, Vikas V. Dukhande and Sabesan Yoganathan*


DOI: 10.2174/1871520619666191028101506
View Abstract View on PubMed


New Uracil Analogs with Exocyclic Methylidene Group as Potential Anticancer Agents


Angelika Długosz-Pokorska, Joanna Drogosz, Marlena Pięta, Tomasz Janecki, Urszula Krajewska, Marek Mirowski and Anna Janecka*


DOI: 10.2174/1871520619666191211104128
View Abstract View on PubMed


Association of GRP78, HIF-1α and BAG3 Expression with the Severity of Chronic Lymphocytic Leukemia


Roghayeh Ijabi, Parisa Roozehdar, Reza Afrisham, Hemen Moradi-Sardareh, Saeed Kaviani, Janat Ijabi and Amirhossein Sahebkar*


DOI: 10.2174/1871520619666191211101357
View Abstract View on PubMed


Abstracts Ahead of Print

Flavonolignans: One Step Further in the Broad-Spectrum Approach of Cancer


Diana S. Antal, Florina Ardelean, Stefana Avram, Ioana Z. Pavel, Corina Danciu*, Codruta Soica and Cristina Dehelean


DOI: 10.2174/1871520620666200124112649
View Abstract


Betulinic Acid and Brosimine B Hybrid Derivatives as Potential Agents against Female Cancers


Nádia M. Garcês de Couto, Júlia B. Willig, Thaís C. Ruaro, Diogo Losch de Oliveira, Andréia Buffon, Diogo A. Pilger, Mara S.P. Arruda, Diogo Miron, Aline R. Zimmer and Simone C.B. Gnoatto*


DOI: 10.2174/1871520620666200124111634
View Abstract




Synthesis and Applications of Hydrogels in Cancer Therapy


Anchal Singhal*, Niharika Sinha, Pratibha Kumari and Manoushikha Purkayastha


DOI: 10.2174/1871521409666200120094048
View Abstract


Cytotoxic Sesquiterpenes from Sonchus oleraceus


Hongying Zhang, Yiding Wang, Shaojiu Wang, Qian Wang, Tianjing Wang, Jie Zhu* and Bing Liu


DOI: 10.2174/1871520620666200101152934
View Abstract



Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib


Mitra Korani, Sara Nikoofal-Sahlabadi, Amin R. Nikpoor, Solmaz Ghaffari, Hossein Attar, Mohammad Mashreghi and Mahmoud R. Jaafari*


DOI: 10.2174/1871520620666200101150640
View Abstract



BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK


Juan-Hua Tian, Li-Jun Mu, Mei-Yu Wang, Jin Zeng, Qing-Zhi Long, Bin Guan, Wen Wang, Yu-Mei Jiang, Xiao-jiNg Bai and Yue-Feng Du*


DOI: 10.2174/1871520620666200101141934
View Abstract


Published Contents

Editor's Choice


Zoning in on Tankyrases: A Brief Review on the Past, Present and Prospective Studies

, 2019; 19(16): 1920 - 1934

Xylia Q. Peters, Thembeka H. Malinga, Clement Agoni, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1871520619666191019114321








Synthesis, Spectroscopic Properties, Crystal Structure And Biological Evaluation of New Platinum Complexes with 5-methyl-5-(2-thiomethyl)ethyl Hydantoin

, 2019; 19(10): 1243 - 1252

Adriana G. Bakalova*, Rossen T. Buyukliev, Rositsa P. Nikolova, Boris L. Shivachev, Rositsa A. Mihaylova and Spiro M. Konstantinov


DOI: 10.2174/1871520619666190214103345





Open Access Articles


Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*





New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi






Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

, 2014; 14(8): 1121 - 1127

Bryan Oronsky, Neil Oronsky, Susan Knox, Gary Fanger and Jan Scicinski




Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

, 2014; 14(6): 840 - 851

Georgina A. Cardama, Maria J. Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe, Adrian G. Turjanski, Daniel F. Alonso, Daniel E. Gomez and Pablo Lorenzano Menna




β2-Microglobulin-mediated Signaling as a Target for Cancer Therapy

, 2014; 14(3): 343 - 352

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Sajni Josson, Hiromitsu Mimata and Leland W. K. Chung





Most Cited Articles

Research Article

Let-7a could serve as a biomarker for chemo-responsiveness to docetaxel in gastric cancer

, 2019; 19(3): 304-309.

Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*


DOI: 10.2174/1871520619666181213110258



Research Article

What makes species productive of anti-cancer drugs? Clues from drugs’ species origin, druglikeness, target and pathway

, 2019; 19(2): 194-203.

Xiaofeng Li, Xiaoxu Li, Yinghong Li, Chunyan Yu, Weiwei Xue, Jie Hu*, Bo Li, Panpan Wang and Feng Zhu*


DOI: 10.2174/1871520618666181029132017


Research Article

3, 3'-Dimethylquercetin inhibits the proliferation of human colon cancer RKO cells through inducing G2/M cell cycle arrest and apoptosis

, 2019; 19(3): 402-409.

Jianguo Wu, Jun Yi, Yanbin Wu, Xuzheng Chen, Jianwei Zeng, Jinzhong Wu* and Wei Peng*


DOI: 10.2174/1871520618666181106120718



Review Article

Immunotherapy in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

, 2019; 19(3): 290-303.

Izabela Łasińska*, Tomasz Kolenda, Anna Teresiak, Katarzyna M. Lamperska, Łukasz Galus and Jacek Mackiewicz


DOI: 10.2174/1871520618666180910092356


Research Article

Novel inhibitors of DNA repair enzyme TDP1 combining monoterpenoid and adamantane fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik


DOI: 10.2174/1871520619666181207094243


Research Article

[10]-gingerol affects multiple metastatic processes and induces apoptosis in MDA-MB-231 breast tumor cells

, 2019; 19(5): 645-654.

Angelina M. Fuzer, Ana C.B.M. Martin, Amanda B. Becceneri, James A. da Silva, Paulo C. Vieira and Marcia R. Cominetti*


DOI: 10.2174/1871520618666181029125607


Research Article

Induction of apoptosis by pierisin-6 in HPV Positive HeLa and HepG2 cancer cells is mediated by the caspase-3 dependent mitochondrial pathway

, 2019; 19(3): 337-346.

Subbarayan Sarathbabu, Satheesh K. Marimuthu, Souvik Ghatak, Subramanian Vidyalakshmi, Guruswami Gurusubramanian, Sankar K. Ghosh, Selvi Subramanian*, Wenqing Zhang and Nachimuthu S. Kumar*


DOI: 10.2174/1871520619666181127113848


Review Article

Phytochemicals in anticancer drug development

, 2019; 19(2): 172-183.

Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K. Madan*


DOI: 10.2174/1871520618666181106115802



General Research Article

Biological activity and physicochemical properties of dipeptidyl nitrile derivatives against pancreatic ductal adenocarcinoma cells

, 2019; 19(1): 112-120.

José C. Quilles Jr, Murillo D.L. Bernardi, Pedro H.J. Batista, Samelyn C.M. Silva, Camila M.R. Rocha, Carlos A. Montanari and Andrei Leitão*


DOI: 10.2174/1871520618666181029141649



General Research Article

Synthesis and investigation of the role of benzopyran dihydropyrimidinone hybrids in cell proliferation, migration and tumor growth

, 2019; 19(2): 276-288.

Ashutosh K. Dash, Debasis Nayak, Nazar Hussain, Mubashir J. Mintoo, Sumera Bano, Archana Katoch, Dilip M. Mondhe, Anindya Goswami* and Debaraj Mukherjee*


DOI: 10.2174/1871520618666180903101422


Review Article

Integrins as a new target for cancer treatment

, 2019; 19(5): 580-586.

Izabela Łasiñska* and Jacek Mackiewicz


DOI: 10.2174/1871520618666181119103413



Most Accessed Articles




Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253-1261.

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*


DOI: 10.2174/1871520619666190404155230


The Warburg Effect and the Hallmarks of Cancer

, 2017; 17(2): 164-170.

Khalid O. Alfarouk, Claudiu T. Supuran and Laurent Schwartz


DOI: 10.2174/1871520616666161031143301




Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs

, 2019; 19(9): 1080-1102.

Ghansham S. More*, Asha B. Thomas, Sohan S. Chitlange, Rabindra K. Nanda and Rahul L. Gajbhiye


DOI: 10.2174/1871520619666190305141458






Editor-in-Chief

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

Biography View Full Editorial Board

Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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