This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy - Presents current information about immunological assays used in research - Presents an overview of T cell immunotherapy and cloning techniques - Presents an overview of tumor cell bioinformatics and its role in immunotherapy - Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking - Presents information in an easy-to-read format for a wide range of readers - Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The eighth volume of this series features reviews that cover the following topics related to the treatment of a variety of CNS disorders, related diseases and basic research: - Emerging Innovative Therapies of Spinal Muscular Atrophy: Current Knowledge and Perspectives - Obesity Induced by The Neurological Drugs - Molecular Mechanism of Nervous System Disorders and Implications for New Therapeutic Targets - Glioma Imaging and Novel Agents - Screening Models for Neuroleptic Drug-Induced Hyperprolactinemia: A Mini-Review

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the book series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research. The fifth volume of this series features 5 chapters that cover these topics: - Clinical Eradication of Latent HIV Reservoirs: Where Are We Now? - HIV-1 Genotypic Drug Resistance Testing and Next-Generation Sequencing - Current and Promising Multiclass Drug Regimens and Long-Acting Formulation Drugs in HIV Therapy - Role of Nanotechnology in HIV Diagnosis and Prognosis - Preventive and Therapeutic Features of Combination Therapy for HIV

Medicinal plants are a source of potential therapeutic compounds. Phytotherapy can give patients long term benefits with less or no side effects. This is the third volume of the series which features monographs on selected natural products used to treat diabetes and hypertension. This volume brings 7 chapters contributed by 22 researchers, that cover updates on the biochemistry of diabetes, information on anti-diabetic and antihypertensive properties of oil bearing plants, herbs, fruits and vegetables, medicinal plants from Asia, as well as the medicinal value of specific plants such as, star apple (Chrysophyllum cainito). In terms of therapeutic agents, two reviews in this volume focus on terpenoids and glucagon-like peptide – 1 are also included. Each review covers different plant species or medicinal agents where applicable, providing readers essential information about their role in the treatment of diabetes and hypertension. Both academic and professional pharmacologists as well as clinicians will find comprehensive information on a variety of therapeutic agents in this volume.

Medicinal plants are a source of potential therapeutic compounds. Phytotherapy can give patients long term benefits with less or no side effects. Phytotherapy in the Management of Diabetes and Hypertension is a book series which emphasizes the biochemistry behind diabetes mellitus and hypertension, along with the control or remediation of these conditions through cost effective, safe and easily-adaptable methods validated by scientific research. This is the fourth volume of the series which features reviews on selected natural products used to treat diabetes and hypertension. This volume brings 6 chapters contributed by 14 researchers that cover general updates on diabetic phytotherapy, circumin, and the medicinal use of olive leaves, passion fruit and spiral gingers in the treatment of diabetes and hypertension. Each review covers different plant species or medicinal agents where applicable, providing readers essential information about their role in the treatment of diabetes and hypertension. Both academic and professional pharmacologists as well as clinicians will find comprehensive information on a variety of therapeutic agents in this volume.

This concise clinical reference facilitates health consultants and professionals for determining treatment options for some common prenatal and postpartum infections during pregnancy and the puerperium in patients. Key Features - Presents 9 organized, easy to read chapters on anti-infective agents for pregnant patients - Covers pharmacokinetics and pharmacodynamics of relevant anti-infective agents - Includes information on classification and safety of anti-infective agents - Includes treatment of urinary tract infections - Covers medications for sexually transmitted diseases, including a complete section dedicated to HIV medication - Provides information about vulvovaginal infections - Covers the treatment of toxoplasmosis in pregnancy - innovates with information about herbal remedies for infection for patients during pregnancy and breastfeeding Pregnancy and Anti-Infective Agents is therefore, a valuable handbook that enables quick consultation on safe antibiotics for the treatment of a variety of infections in pregnancy.

21st Century Challenges in Antimicrobial Therapy and Stewardship addresses selected topics that are of importance in the practice of infectious disease management. The text starts by illustrating the global landscape of antimicrobial drug resistance, which influences antimicrobial use and therapeutic decisions in the clinic. The contributors explain the reasons for the spread of antibiotic resistance, the pharmacology of antibiotics of different classes, innovative drug delivery methods which can improve the efficacy and safety of new drug candidates and achieve targeted drug delivery as well as drug resistance monitoring techniques and issues in the practice of antimicrobial stewardship and infection control. Key Features: - 14 organized chapters on several aspects of antimicrobial therapy and stewardship - Introductory knowledge on global antimicrobial trends - Coverage of molecular basis of antimicrobial resistance in gram positive, gram negative and fungal microbes - Focused coverage on new developments in antimicrobial drug development, drug delivery, formulation and diagnostic tools - Information on unmet needs of patients and clinicians, including the treatment of difficult infections - Comprehensive coverage of issues in antimicrobial stewardship 21st Century Challenges in Antimicrobial Therapy and Stewardship brings to readers – healthcare administrators, educators, pharmacists, clinicians and students, alike – the knowledge of the molecular basis of antimicrobial drug therapy, drug resistance in pathogens and current practices in antimicrobial stewardship programs. This knowledge, in turn, fosters an awareness among healthcare industry participants to collaborate in an interprofessional environment to combat multidrug resistance.

Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms. The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers. The topics covered in this volume are: - Recent Patents on Exosome-Derived Therapeutic Agents - Serrated Lesions of the Colon and Rectum: An Overview of Pathology and Emphasis on a New Classification - Introducing the 188W/188Re and 144Ce/144Pr Plaques for Eye Cancers Brachytherapy - ShcA Family of Adaptor Proteins: Dual Role in Cell Growth - Hormones Management as Anticancer Treatment and Protection: Functions and Mechanism of Action

Frontiers in Clinical Drug Research – Hematology is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of anemias, coagulopathies, vascular diseases and hematological malignancies. Reviews in this series also include research on specific antibody targets, therapeutic methods, genetic hemoglobinopathies and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Hematology is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of hematology, oncology and vascular pharmacology. The fourth volume of this series features 5 reviews: -TRP Channels: Potential Therapeutic Targets in Blood Disorders -Hypercoagulable States: Clinical Symptoms, Laboratory Markers and Management -Advanced Applications of Gene Therapy in the Treatment of Hematologic Disorders -Ferroptosis - Importance and Potential Effects in Hematological Malignancies -Clinical Application of Liquid Biopsy in Solid Tumor HCC: Prognostic, Diagnostic and Therapy Monitoring Tool

Tuberculosis is an infection of the lungs caused by Mycobacterium tuberculosis and related species. It is prevalent in tropical regions and continues to occur in more than 10 million new individuals annually and despite many advances in medicine, still results in 1.3 million deaths annually. This clinical practice handbook presents information on all topics related to the disease, including its epidemiology, microbiology, clinical features, diagnostic procedures, treatments, BCG vaccination and infection control in health facilities. Special topics such as the treatment of tuberculosis is pediatric patients, surgery, multi-drug resistance and adverse reactions to tuberculosis drugs are also covered. Information is presented in 16 simple easy-to read chapters with key figures, tables and references that help to explain relevant topics. Tuberculosis: A Clinical Practice Guide is an ideal reference manual for medical students and healthcare personnel seeking information about tuberculosis.