Letters in Drug Design & Discovery

Letter Article

Screening, Deconvolution and Parallel Synthesis of Trisubstituted Piperazine and Trisubstituted 2,3-diketopierazine Libraries for the Rapid Identification of Antagonists of the Nuclear Retinoic Acid Receptor-related Orphan Receptor Gamma (RORγ)

Pp: 829-835
Author(s): Maria A. Ortiz, Francisco J. Piedrafita, Ashley Bunnell and Adel Nefzi*
DOI: 10.2174/1570180820666230130093524
Published on: 24 February, 2023

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Mini-Review Article

Anticancer Drug Development: Evaluative Architecture

Pp: 836-846
Author(s): Da-Yong Lu*, Bin Xu and Ting-Ren Lu
DOI: 10.2174/1570180819666220610102444
Published on: 21 February, 2023

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Review Article open access plus

Magnetic Nanoparticles with Aspects of their Use in Cancer Therapy

Pp: 847-857
Author(s): Rasit Dinc*
DOI: 10.2174/1570180820666230228103903
Published on: 27 March, 2023

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Review Article

Aptamers-based Strategies for the Treatment of Microbial Infections

Pp: 858-865
Author(s): Annalisa Di Rienzo*, Lisa Marinelli, Antonio Di Stefano, Giuseppina Vicaretti and Ivana Cacciatore
DOI: 10.2174/1570180820666230214093038
Published on: 02 March, 2023

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Review Article

Emerging Heterocyclic Epidermal Growth Factor Receptor Inhibitors for the Management of Cancer: A Chemical Review

Pp: 866-879
Author(s): Rupali Likhar*, Amey Deshpande, Tabassum Khan and Arati Prabhu
DOI: 10.2174/1570180820666230417093528
Published on: 08 May, 2023

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Research Article

Demonstration of Interaction between Carbapenem Group Antibiotics and Different Immunosuppressant Drugs by Molecular Docking

Pp: 880-887
Author(s): Deniz Karatas, Ataman Gonel*, Ismail Koyuncu, Ebru Temiz, Kadir Egi, Mustafa Durgun, Sukru Akmese and Murat Caglayan
DOI: 10.2174/1570180820666230224104658
Published on: 21 March, 2023

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Research Article

QbD Assisted Development and Validation of UV Spectroscopic Method in Estimation of Silymarin

Pp: 888-896
Author(s): Ashwini Kumar Mishra, S.L. Neha, Laxmi Rani, Hitesh Kumar Dewangan and Pravat Kumar Sahoo*
DOI: 10.2174/1570180820666230126121026
Published on: 24 February, 2023

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Research Article

Huatan Tongluo Decoction Inhibits Inflammatory Infiltration and Airway Remodeling by Attenuating TGF-β1/Smad2/3 and Oxidative Stress-mediated NF-kB/HIF-1α/MMPs Signaling Pathway in Chronic Asthma Mice

Pp: 897-904
Author(s): Huimin Lao*, Mengqi Chen, Xuanyu Liu, Libo Li, Qian Li and Baoqing Zhang
DOI: 10.2174/1570180820666230117141701
Published on: 01 March, 2023

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Research Article

Thiazole Derivatives as RORγt Inhibitors: Synthesis, Biological Evaluation, and Docking Analysis

Pp: 905-917
Author(s): Isha Mishra*, Phool Chandra and Neetu Sachan
DOI: 10.2174/1570180820666230217123456
Published on: 15 March, 2023

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Research Article

Development and Characterization of Enteric Polymer-based Solid Dispersion for Cholecalciferol Delivery

Pp: 918-927
Author(s): Neha Rawat*, Shashank K. Singh and Ashish Baldi*
DOI: 10.2174/1570180820666230130093355
Published on: 14 February, 2023

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Research Article

Synthesis and Biological Evaluation of Novel Oxazolidinone Derivatives Containing Dithiocarbamate Moiety as Antibacterial Agents

Pp: 928-937
Author(s): Xiudong Ding, Zhanfeng Gao, Siyu Liu, Sicong Xu, Zhiwei Li, Jia Jiang, Ruixi Fan, Tong Chen, Yanfang Zhao, Hengzhi Lu* and Yunlei Hou*
DOI: 10.2174/1570180820666230118124058
Published on: 16 February, 2023

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Research Article

Characterization and Antibacterial Activity of Melanin Pigment from Marine Bacterium Actinoalloteichus cyanogriseus

Pp: 938-947
Author(s): Muddukrishnaiah Kotakonda, Makesh Marappan* and Bhaskar Biswas
DOI: 10.2174/1570180820666230131093932
Published on: 14 February, 2023

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Research Article

Aryl-isoquinoline as a Potential Scaffold for Novel Antitumor Agents against Glioblastoma Cells

Pp: 948-960
Author(s): Thais Batista Fernandes, Rosania Yang, Glaucio Monteiro Ferreira, Priscila Oliveira de Souza, Vitor Galvão Lopes, Mônica Franco Zannini Junqueira Toledo, Gabriela Gonçalves Roliano, Gabriela Nogueira Debom, Sandra Valeria Vassiliades, Neuza Mariko Aymoto Hassimotto, Mario Hiroyuki Hirata, Elizandra Braganhol and Roberto Parise-Filho*
DOI: 10.2174/1570180820666230131111033
Published on: 22 February, 2023

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Research Article

In silico Identification of HDAC Inhibitors for Multiple Myeloma: A Structure-based Virtual Screening, Drug Likeness, ADMET Profiling, Molecular Docking, and Molecular Dynamics Simulation Study

Pp: 961-978
Author(s): Abhijit Debnath*, Rupa Mazumder, Avijit Mazumder, Rajesh Singh and Shikha Srivastava
DOI: 10.2174/1570180820666230125102954
Published on: 14 February, 2023

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Research Article

Exploring Novel PLK1 Inhibitors based on Computational Studies of 2,4-Diarylaminopyrimidine Derivatives

Pp: 979-990
Author(s): Honghao Yang, Yilan Zhao, Xiaojiao Zheng, Xiulian Ju, Fengshou Wu, Xiaogang Luo, Qi Sun* and Genyan Liu*
DOI: 10.2174/1570180820666230801114905
Published on: 16 October, 2023

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Letters in Drug Design & Discovery

Volume 21, Issue 5 , 2024