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ISSN (Print):
1570-1808
ISSN (Online):
1875-628X

Letters in Drug Design & Discovery

Starting from Volume 22, LDDD will be published by INTERNATIONAL LIFE SCIENCES PUBLISHERS (The journal homepage is under construction)

Impact Factor: 1.2

Indexed in: Scopus, SCI Expanded, JCR... View all

Volume 21 , Issues 16, 2024

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Volume 21, Issue 16 , 2024

Mini-Review Article

A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development

Pp: 3319-3331
Author(s): Mridula Chauhan, Shivansh Kumar, Arpon Biswas, Mukesh Kumar, Sarvesh Kumar Verma, Anjali Mishra, Vaishali Singh, Amol Chhatrapati Bisen, Sristi Agrawal, Abhijit Deb Choudhury, Ramakrishna Rayiti and Rabi Sankar Bhatta*
DOI: 10.2174/0115701808287654240126112003
Published on: 02 February, 2024

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Review Article

Anti-Tumor Activity of Indole: A Review

Pp: 3332-3348
Author(s): Momen R.F. Mohamed*, Mai E. Shoman*, Taha F. S. Ali and Gamal El-Din A. Abuo-Rahma*
DOI: 10.2174/0115701808288928240226104445
Published on: 08 March, 2024

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Review Article

P-glycoproteins in the Pathology and Treatment of Alzheimer's Disease

Pp: 3349-3374
Author(s): Raghad H. Aljohani, Nouf F. Alruwali, Shorooq M. Alrashedi, Somaya M. Yousef, Shahad T. Alobaidan, Nehal M. Elsherbiny and Hebatallah H. Atteia*
DOI: 10.2174/0115701808293022240216070603
Published on: 28 February, 2024

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Research Article

Ligand-based Molecular Modeling of HDL Receptor SR-BI Inhibitors as Potent Anti-hyperlipidemic Agents

Pp: 3375-3388
Author(s): Swati Verma* and Sarvesh Paliwal
DOI: 10.2174/0115701808239749230921113101
Published on: 05 April, 2024

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Research Article

Computational Insights on Migraine and Anxiety in Association with BDNF

Pp: 3389-3407
Author(s): Sakthi Sasikala Sundaravel, Beena Briget Kuriakose, Sakeena Mushfiq and Karthikeyan Muthusamy*
DOI: 10.2174/0115701808274096231207042744
Published on: 02 February, 2024

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Research Article

Design and Synthesis of Novel Anti-proliferative Formononetin Derivatives

Pp: 3408-3424
Author(s): Zeping Luo*, Liwei Pan, XiuJu Yin and Hailin Chen
DOI: 10.2174/0115701808278216231228045423
Published on: 04 March, 2024

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Research Article

A Deep Dive into PDE5 Inhibition: Innovative Discoveries via Virtual Screening

Pp: 3425-3442
Author(s): Abhijit Debnath, Hema Chaudhary*, Parul Sharma, Rajesh Singh and Shikha Srivastava
DOI: 10.2174/0115701808279586231221043744
Published on: 03 April, 2024

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Research Article

Development of Potential Antidiabetic Agents using 2D and 3D QSAR, Molecular Docking and ADME Properties In-silico Studies of α-amylase Inhibitors

Pp: 3443-3464
Author(s): Kalusing S. Padvi, Aniket P. Sarkate*, Shashikant V. Bhandari and Mahadevi V. Kendre
DOI: 10.2174/0115701808279839240206123454
Published on: 21 February, 2024

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Research Article

QSAR Analysis and Molecular Docking Studies of Aryl Sulfonamide Derivatives as Mcl-1 Inhibitors and the Influence of Structure and Chirality on the Inhibitory Activity

Pp: 3465-3478
Author(s): Jia Chen, Yang Ma, Jian-Wei Zou, Sheng Hu, Meilan Huang and Guixiang Hu*
DOI: 10.2174/0115701808278918240109053316
Published on: 30 January, 2024

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Research Article

In Silico Structure-based Screening of Potential Anticancer Bioactive Natural Constituents from African Natural Products

Pp: 3479-3492
Author(s): Khairedine Kraim*, Atidel Boudjedir, Youcef Saihi, Fatima Zohra Oueld Chikh, Yassira Slatnia and Fouad Ferkous
DOI: 10.2174/0115701808280302240117055932
Published on: 06 February, 2024

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Research Article

Predicting the Pharmacological Targets of Astragalus membranaceus against Hypertensive Nephropathy

Pp: 3493-3505
Author(s): Ningxin Zhang, Chen Guan, Lingyu Xu, Zengying Liu, Chenyu Li, Quandong Bu, Xuefei Shen and Yan Xu*
DOI: 10.2174/0115701808285471240216040105
Published on: 26 February, 2024

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Research Article

Design and Biological Evaluation of Cephalosporin Based Metallo-β-lactamase (MBL) Inhibitors

Pp: 3506-3514
Author(s): Shaan Patel*, Pradip Jadav*, Rajesh Bahekar, Kumargurubaran Nagaswamy, Kasinath Viswanathan, Purvi Vyas, Poonam Giri, S. Sachchidanand and Mukul Jain
DOI: 10.2174/0115701808287192240415062148
Published on: 24 April, 2024

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Research Article

Fluconazole Microemulsions: Preparation, Statistical Optimization by Two-level Factorial Design, and Physicochemical Evaluation

Pp: 3515-3525
Author(s): Payam Khazaeli*, Abbas Pardakhty, Gholamreza Dehghannoudeh, Sina Safizade, Marzieh Sajadi Bami and Mandana Ohadi*
DOI: 10.2174/0115701808287346240228120148
Published on: 11 March, 2024

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Research Article

Effects of Compound in Hedyotis diffusa Willd against Acute Myeloid Leukemia: An In Silico and In Vitro Study

Pp: 3526-3541
Author(s): Chunyi Lyu, Xuewei Yin, Zonghong Li, Teng Wang and Ruirong Xu*
DOI: 10.2174/0115701808287616240321080922
Published on: 15 April, 2024

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Research Article

Exploring and Designing Potential Inhibitors of SIRT2 in Natural Products by Artificial Intelligence (AI) and Molecular Dynamics Methods

Pp: 3542-3554
Author(s): Yangyang Ni, Juxia Bai, Yuqi Zhang, Haoran Qiao, Liqun Liang, Junfeng Wan, Yanyan Zhu, Haijing Cao, Huiyu Li* and Qingjie Zhao*
DOI: 10.2174/0115701808288696240308052948
Published on: 12 March, 2024

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Research Article

Synthesis, Antiproliferative Evaluation, and Molecular Docking of Thieno[3,2-e]indazole Derivatives

Pp: 3555-3576
Author(s): Rafat M. Mohareb*, Ibram Refat Mikhail, Marwa Soliman Gamaan and Ensaf S. Alwan
DOI: 10.2174/0115701808287763240302165049
Published on: 13 March, 2024

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Research Article

A Linear and Nonlinear QSAR Analysis of Benzimidazole Derivative XY123 in Prostate Cancer Treatment

Pp: 3577-3589
Author(s): Bing Li and Xiaoqiang Liu*
DOI: 10.2174/0115701808291381240226094729
Published on: 06 March, 2024

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Research Article

Design, Synthesis, and In vitro Biological Activities of Matrine Skeleton Derivatives as Potential Cancer Inhibitors

Pp: 3590-3603
Author(s): Bin Zhou, Lisheng Wang*, Yongquan Wei, Meiyan Jiang and Xingdong Wang
DOI: 10.2174/0115701808300981240408063655
Published on: 15 April, 2024

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Research Article

Structural Insights into Mouse β3-adrenergic Receptor: A Promising Target for Obesity and Diabetes Therapeutics

Pp: 3604-3621
Author(s): Vijayalakshmi Gangadhara, Kavishankar Gawli and Asha Abraham*
DOI: 10.2174/0115701808301580240405071948
Published on: 18 April, 2024

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Short Communication

Do Anticancer Medicinal Compounds have DNMT1 Regulating Activity: An In silico Investigation

Pp: 3622-3630
Author(s): Fahad Hassan Shah* and Song Ja Kim*
DOI: 10.2174/0115701808265886230921115023
Published on: 09 February, 2024

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