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Review Article

硫醇依赖性抗氧化系统在细菌药物敏感性和耐药性中的作用和机理

卷 27, 期 12, 2020

页: [1940 - 1954] 页: 15

弟呕挨: 10.2174/0929867326666190524125232

价格: $65

Open Access Journals Promotions 2
摘要

抗生素在预防和治疗细菌感染性疾病中起着不可替代的作用。然而，由于抗生素的不当使用，细菌耐药性成为全世界公共卫生的主要挑战。诸如谷胱甘肽之类的小硫醇分子可以直接与某些抗生素反应并结合，从而有助于药物的敏感性和耐药性。最近，越来越多的证据表明，某些抗生素的抗菌活性与活性氧（ROS）之间有着密切的联系。硫氧还蛋白和谷胱甘肽系统是维持细胞ROS水平的两个主要细胞二硫键还原酶系统。因此，这两个硫醇依赖性抗氧化剂系统可能会影响抗生素的敏感性和耐药性。微生物配备了不同的硫醇依赖性抗氧化剂系统，这使硫醇依赖性抗氧化剂系统在抗生素敏感性中的作用和耐药性在各种细菌中有所不同。在这里，我们将集中于对巯基依赖性抗氧化剂系统在细菌抗生素敏感性和耐药性方面的研究进展进行综述。

关键词: 抗生素，耐药性，ROS，硫醇，硫氧还蛋白系统，谷胱甘肽。

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