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Review Article

治疗幽门螺杆菌感染的主要目标——脲酶抑制剂设计的见解

卷 27, 期 23, 2020

页: [3967 - 3982] 页: 16

弟呕挨: 10.2174/0929867326666190301143549

价格: $65

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摘要

脲酶由多种植物、真菌和细菌表达，与许多细菌的毒力因子直接相关，其中包括幽门螺杆菌。幽门螺杆菌是一种与多种胃肠疾病有关的革兰氏阴性菌，是世界上最常见的细菌感染之一。幽门螺杆菌脲酶(HPU)是一种镍依赖性金属酶，在胃的酸性pH引起的环境应激下表达。该酶通过尿素水解产物的酸性中和作用，促进胃pH值的增加，进而对微生物的定植和发病起关键作用。与此同时，幽门螺杆菌感染的标准治疗也存在局限性，如临床应用中细菌对抗生素的耐药性不断增加。作为开发新型治疗手段的一种策略，脲酶抑制剂已被证明是很有前景的，有广泛的化合物，包括天然的、合成的和半合成的产品被研究和潜在开发为新药。在此背景下，本文综述了HPU抑制领域的进展，提出并讨论了研究新分子的基础，旨在识别更有效的治疗实体。

关键词: 幽门螺杆菌，脲酶，给药，消化性溃疡，胃炎，胃腺癌。

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