[1]
Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 2005; 74: 739-89.
[2]
Frakes AE, Dillin A. The UPRER. sensor and coordinator of organismal homeostasis. Mol Cell 2017; 66(6): 761-71.
[3]
Fujita E, Kouroku Y, Isoai A, et al. Two Endoplasmic Reticulum-Associated Degradation (ERAD) systems for the novel variant of the mutant dysferlin. Ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). Hum Mol Genet 2007; 16(6): 618-29.
[4]
Yorimitsu T, Klionsky DJ. Endoplasmic reticulum stress. A new pathway to induce autophagy. Autophagy 2007; 3(2): 160-2.
[5]
Ogata M, Hino S, Saito A, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26(24): 9220-31.
[6]
Yoshimori T. Autophagy: A regulated bulk degradation process inside cells. Biochem Biophys Res Commun 2004; 313(2): 453-8.
[7]
Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19(21): 5720-8.
[8]
Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290(5497): 1717-21.
[9]
Glick D, Barth S, Macleod KF. Autophagy: Cellular and molecular mechanisms. J Pathol 2010; 221(1): 3-12.
[10]
Galluzzi L, Vicencio JM, Kepp O, Tasdemir E, Maiuri MC, Kroemer G. To die or not to die: That is the autophagic question. Curr Mol Med 2008; 8(2): 78-91.
[11]
Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6(4): 463-77.
[12]
Klionsky DJ, Abeliovich H, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4(2): 151-75.
[13]
Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta 2013; 1833(12): 3448-59.
[14]
Rami A, Kögel D. Apoptosis meets autophagy-like cell death in the ischemic penumbra. Two sides of the same coin? Autophagy 2008; 4(4): 422-6.
[15]
Rami A. Autophagy in neurodegeneration: Firefighter and/or incendiarist? Neuropathol Appl Neurobiol 2009; 35(5): 449-61.
[16]
Yorimitsu T, Nair U, Yang Z, Klionsky DJ. Endoplasmic reticulum stress triggers autophagy. J Biol Chem 2006; 281(40): 30299-304.
[17]
Rani V, Deshmukh R, Jaswal P, Kumar P, Bariwal J. Alzheimer's
disease. Is this a brain specific diabetic condition? Physiol Behav 2016; 164(ptA). : 259-67.
[18]
Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3(6): 542-5.
[19]
Martindale JJ, Fernandez R, Thuerauf D, et al. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ Res 2006; 98(9): 1186-93.
[20]
Liu S, Sarkar C, Dinizo M, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis 2015; 6: e1582.
[21]
Iwata A, Christianson JC, Bucci M, et al. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc Natl Acad Sci USA 2005; 102(37): 13135-40.
[22]
Ravikumar B, Berger Z, Vacher C, O’Kane CJ, Rubinsztein DC. Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet 2006; 15(7): 1209-16.
[23]
Steiger-Barraissoul S, Rami A. Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons. Apoptosis 2009; 14(11): 1274-88.
[24]
Fekadu J, Rami A. Beclin-1 deficiency alters autophagosome formation, lysosome biogenesis and enhances neuronal vulnerability of HT22 hippocampal cells. Mol Neurobiol 2016; 53(8): 5500-9.
[25]
Koike M, Shibata M, Tadakoshi M, et al. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 172(2): 454-69.
[26]
Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441(7095): 885-9.
[27]
Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441(7095): 880-4.
[28]
Carloni S, Buonocore G, Balduini W. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 2008; 32(3): 329-39.
[29]
Martinez-Vicente M. Autophagy in neurodegenerative diseases. From pathogenic dysfunction to therapeutic modulation. Semin Cell Dev Biol 2015; 40: 115-26.
[30]
Sarkar S, Rubinsztein DC. Small molecule enhancers of autophagy for neurodegenerative diseases. Mol Biosyst 2008; 4(9): 895-901.
[31]
Sarkar S, Rubinsztein DC. Huntington’s disease: Degradation of mutant huntingtin by autophagy. FEBS J 2008; 275(17): 4263-70.
[32]
Vidal RL, Matus S, Bargsted L, Hetz C. Targeting autophagy in neurodegenerative diseases. Trends Pharmacol Sci 2014; 35(11): 583-91.
[33]
Portbury SD, Hare DJ, Sgambelloni C, et al. Trehalose improves cognition in the transgenic Tg2576 mouse model of Alzheimer’s disease. J Alzheimers Dis 2017; 60(2): 549-60.
[34]
Castillo K, Nassif M, Valenzuela V, et al. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 2013; 9(9): 1308-20.
[35]
Mardones P, Rubinsztein DC, Hetz C. Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport. Sci Signal 2016; 9(416): fs2.
[36]
Li Y, Guo Y, Wang X, et al. Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model. Neuroscience 2015; 298: 12-25.
[37]
Li Y, Luo Y, Luo T, et al. Trehalose inhibits protein aggregation caused by transient ischemic insults through preservation of proteasome activity, not via induction of autophagy. Mol Neurobiol 2017; 54(9): 6857-69.
[38]
Tanji K, Miki Y, Maruyama A, et al. Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease. Biochem Biophys Res Commun 2015; 465(4): 746-52.
[39]
Redmann M, Wani WY, Volpicelli-Daley L, Darley-Usmar V, Zhang J. Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biol 2017; 11: 429-37.
