Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. It should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.

One of the most extraordinary characteristics of Mycobacterium tuberculosis infection is its capacity to remain within the host's tissues for a long period of time. There is an enormous reservoir of persons latently infected with tuberculosis (LTBI) estimated at about a third of the world's population. From this reservoir arise about 10 million new cases of active TB and more than two million deaths occur annually. Current Diagnosis of Infant Tuberculosis Infection covers problems concerning the diagnosis of LTBI, giving an overview of commercially available options and, unlike most reviews on this subject, also points out some tools currently under development. The Ebook provides comprehensive understandable, practice-oriented information on this subject, while keeping frontier research developments in consideration. It serves as an update to readers from universities to the research center and hospital staff - as well as a guide for helping clinicians to improve their diagnostic skills regarding TB infections in an endemic country (such as Brazil).

The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in continuous progress in fundamental knowledge about molecular and cellular mechanisms in hematological neoplasia. Physiopathogenesis of Hematological Cancer presents a concise overview of the cellular and molecular biology of myelo- and Lymphoproliferative disorders. The expert reviews presented within this e-book are also accompanied by bibliographic references for relevant scientific literature. This book should prove to be a valuable reference tool for both medical graduate and postgraduates in the field of oncology.

This e-book provides a comprehensive overview of state of the art applications of biomolecular techniques that are currently used, or are in development in the field of microbiological diagnostics research. In this respect, the topics covered include, genomics, proteomics, immunologics, biosensors, microarrays and nano-culture technologies. The broad range of techniques covered by the book will be invaluable to readers from professions allied to (but not exclusive to) microbiology analysts and researchers, laboratory technicians, (medical) microbiologists, molecular biologists, analytical physicists, and physicians.

This e-book is based on a critical evaluation of existing literature on salivary cortisol, aiming to evaluate the utility of salivary cortisol as a biomarker in various settings. It focuses on how different ways of evaluating levels of salivary cortisol may have an impact on the interpretation of cortisol measurements in various contexts. This e-book focuses on salivary cortisol in relation to the following topics: psychosocial work environment (effort reward imbalance and job demand vs control model), psychosocial resources (mastery, perceived control, sense of coherence), psychosocial risk factors (perceived stress, depression, vital exhaustion, burn-out), sleep quality, biological markers (bodily factors, cardiovascular risk factors, inflammation and metabolism) and somatic outcome. This ebook should serve as a reference for studies planned to adopt cortisol as an assessment tool.

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecular targets and rational drug design on this molecular basis should help in discovering early cancer biomarkers as well as novel therapeutic drugs. This book describes various cancer topics on a molecular level and integrates information on the relationship between causes of cancer, cancer cell biology, metastasis, cancer prevention and drug design. This book should prove to be an extraordinary reference text for students, physicians and oncologists.

Multiple drug resistance among bacteria has become a global issue with a considerable impact on the mortality associated with infectious diseases. This book is a detailed compilation of available knowledge on the surveillance and mechanisms of antibiotic resistance in various countries throughout the world. Readers will be updated on current information on the understanding of mechanisms involved in drug resistance and the geographical distribution of resistance determinant markers. This volume should be a useful guide for microbiologists and clinicians interested in designing antimicrobial therapies tailored for patients in specific geographical regions.

Awake thoracic surgery is a new surgical field that is set to expand in the near future. Employing sole epidural or local anaesthesia in fully awake patients renders many thoracic surgical procedures doable with less invasiveness and general anaesthesia related adverse effects can be avoided. This, in turn, facilitates fast track surgery and improves cost-effectiveness of treatment procedures. The book explains issues relevant to awake thoracic surgery including postoperative immunologic and stress-hormone responses, lung volume reduction surgery, pulmonary resections and thymectomy. This Ebook should be useful to readers interested in a comprehensive reference work on this intriguing minimally invasive surgical option.

Liver cancer, cirrhosis and nonalcoholic fatty liver disease are observed predominately in men. Being male or female is believed to be an important human variable that affects health and liver disease throughout the life span. However, few works have been published on the biological mechanisms underlying gender specific differences in liver disease. Several mechanisms underlying sex-associated differences of progression of liver disease are demonstrated in this e-book based on biological factors as estrogen and hepatic iron stores. Readers will gain a better understanding of the pathogenesis of these sex-associated differences in liver disease and on how to design healthcare for liver disease more effectively for individuals belonging to both genders. The e-book should be a useful reference on gender specific medicine for counselors and clinicians as well as for patients with chronic liver disease.