Title:Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout
Volume: 20
Issue: 2
Author(s): Mahnaz Arian, Mina AkbariRad*, Ahmad Bagheri Moghaddam, Abdollah Firoozi and Mohammad Jami
Affiliation:
- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords:
Allopurinol, drug-induced meningitis, bacterial meningitis, consciousnes, gout, hyperuricemia.
Abstract:
Allopurinol is an FDA -Approved xanthine oxidase inhibitor, which is effective in the
treatment of gout, hyperuricemia and uremic kidney stones in patients with an increased level of
uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine into uric acid,
and therefore its inhibition results in decreased production of uric acid. The most common side effects
of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness,
abnormal hair loss, fever and hypersensitivity reaction.
Case Presentation: This report represents a case of drug-induced meningitis of a senile man who
ended up in the ICU due to the remarkably reduced state of consciousness.
