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Review Article

tiRNA和tRFs的生物发生和疾病调控：综述

卷 26, 期 31, 2019

页: [5849 - 5861] 页: 13

弟呕挨: 10.2174/0929867326666190124123831

价格: $65

摘要

tiRNA和tRF是一类小分子非编码tRNA，其来源于对成熟或前体tRNA的精确加工。 所描述的大多数tiRNA和tRF都来自细胞核编码的tRNA，仅报道了少数tiRNA和tRF。 已经表明它们在抑制蛋白质合成，调节基因表达，引发病毒逆转录酶和调节DNA损伤反应中起重要作用。 但是，对tiRNA和tRF的调节机制和潜在功能的了解仍然很少。 这篇综述旨在描述tiRNA和tRF，包括其结构，生物学功能和亚细胞定位。 还详细讨论了tiRNA和tRF在翻译，神经变性，代谢性疾病，病毒感染和致癌性中的调控作用。 最后，还强调了这些非编码tRNA作为生物标志物和基因调节剂在不同疾病中的潜在应用。

关键词: tRNA，tiRNA，tRF，miRNA，疾病的生物发生，调控，生物发生。

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