![conference banner](/images/conference-banner.jpeg)
摘要
背景:一氧化氮(NO)是关键信号分子,在炎症中具有重要作用。它可以由内皮细胞,嗜中性粒细胞和其他细胞分泌,一旦循环,NO在调节各种嗜中性粒细胞的细胞活动和命运中起着重要作用。 目的:描述NO及其伴随的过氧亚硝酸盐对中性粒细胞的细胞反应及中性粒细胞凋亡的信号传导机制。 方法:回顾文献以评估NO对中性粒细胞的影响。 结果:NO在各种嗜中性粒细胞的细胞活动以及与其他细胞的相互作用中起着重要作用。中性粒细胞的特征性细胞活性是粘附和吞噬作用。 NO通过阻止嗜中性粒细胞粘附和活化的嗜中性粒细胞破坏内皮细胞而在嗜中性粒细胞-内皮相互作用中起保护作用。 NO抑制中性粒细胞的吞噬活性,但通过肾小管小体延伸或细胞因子刺激长距离接触相互作用。中性粒细胞是超氧化物的主要来源,但NO流动导致过亚硝酸盐的形成,过氧亚硝酸盐是一种具有高生物活性的化合物。过氧亚硝酸盐参与类二十烷酸生物合成的调节并抑制内皮前列环素合酶。 NO和过亚硝酸盐调节细胞5-脂氧合酶活性和白三烯合成。嗜中性粒细胞长期暴露于NO会导致细胞死亡机制和嗜中性粒细胞凋亡的激活。 结论:一氧化氮和一氧化氮/一氧化氮相互作用调节中性粒细胞生命和死亡的微调机制。
关键词: 中性粒细胞,粘附,细胞因子,吞噬作用,5-脂氧合酶,白三烯,细胞凋亡。
[http://dx.doi.org/10.1097/00005344-198406002-00008] [PMID: 6206342]
[http://dx.doi.org/10.1038/327524a0] [PMID: 3495737]
[http://dx.doi.org/10.1016/0006-2952(89)90403-6] [PMID: 2567594]
[http://dx.doi.org/10.1038/27019] [PMID: 9790176]
[http://dx.doi.org/10.1038/3182] [PMID: 9790176]
[http://dx.doi.org/10.1126/science.282.5389.610] [PMID: 9841408]
[http://dx.doi.org/10.1016/0006-291X(89)92506-0] [PMID: 2541713]
[http://dx.doi.org/10.1002/jlb.58.5.616] [PMID: 7595064]
[http://dx.doi.org/10.1006/excr.2001.5227] [PMID: 11399050]
[http://dx.doi.org/10.1111/j.1574-695X.2009.00560.x] [PMID: 19453754]
[http://dx.doi.org/10.1038/nrmicro1004] [PMID: 15378046]
[http://dx.doi.org/10.1002/alr.21966] [PMID: 28544570]
[http://dx.doi.org/10.1042/bj2980249] [PMID: 7510950]
[http://dx.doi.org/10.1016/j.jinorgbio.2004.11.007] [PMID: 15598509]
[http://dx.doi.org/10.1021/bi00144a001] [PMID: 1379068]
[http://dx.doi.org/10.1042/bj3570593] [PMID: 11463332]
[http://dx.doi.org/10.1046/j.1365-201x.2000.00629.x] [PMID: 10691776]
[http://dx.doi.org/10.1016/0014-5793(79)81124-2] [PMID: 220088]
[http://dx.doi.org/10.1016/j.biocel.2007.10.003] [PMID: 18036868]
[http://dx.doi.org/10.1016/j.bbabio.2010.01.032] [PMID: 20122895]
Rabelink, T.J.; van Faassen, E.E. Origin of superoxide pro duction by endothelial nitric oxide synthase. FEBS Lett., 1998, 438(3), 161-164.
[http://dx.doi.org/10.1016/S0014-5793(98)01292-7] [PMID: 9827538]
[http://dx.doi.org/10.1074/jbc.273.35.22635] [PMID: 9712892]
[http://dx.doi.org/10.1161/01.ATV.0000168896.64927.bb] [PMID: 15879305]
[http://dx.doi.org/10.1128/microbiolspec.MCHD-0018-2015] [PMID: 27726789]
[http://dx.doi.org/10.1016/j.abb.2008.10.023] [PMID: 18983814]
[PMID: 2553726]
[http://dx.doi.org/10.1006/abbi.1999.1143] [PMID: 10222043]
[http://dx.doi.org/10.1074/jbc.M102341200] [PMID: 11373284]
[http://dx.doi.org/10.1007/978-3-319-63245-2_6] [PMID: 29047082]
[http://dx.doi.org/10.1111/bph.13498] [PMID: 27079449]
[http://dx.doi.org/10.1152/physrev.00029.2006] [PMID: 17237348]
[http://dx.doi.org/10.1073/pnas.98.1.355] [PMID: 11134509]
[http://dx.doi.org/10.4155/fso.15.59] [PMID: 28031866]
[http://dx.doi.org/10.1074/jbc.M201939200] [PMID: 12006567]
[http://dx.doi.org/10.1063/1.4885144] [PMID: 25005287]
[http://dx.doi.org/10.1016/j.jinorgbio.2012.08.027] [PMID: 23102503]
[http://dx.doi.org/10.1007/s11010-009-0318-8] [PMID: 20012469]
[http://dx.doi.org/10.1023/A:1020150124721] [PMID: 10888468]
[http://dx.doi.org/10.1097/MOH.0b013e32833338f3] [PMID: 19864946]
[http://dx.doi.org/10.1586/1744666X.2014.922876] [PMID: 24867165]
[http://dx.doi.org/10.1073/pnas.0709681104] [PMID: 18048324]
[http://dx.doi.org/10.1139/y93-012] [PMID: 8513436]
[http://dx.doi.org/10.1016/j.niox.2006.02.004] [PMID: 16621629]
[http://dx.doi.org/10.1016/j.freeradbiomed.2009.05.019] [PMID: 19477267]
[http://dx.doi.org/10.3390/ijms14047542] [PMID: 23567270]
[http://dx.doi.org/10.1021/acs.chemrev.7b00568] [PMID: 29400454]
[http://dx.doi.org/10.1016/S0092-8674(01)00495-0] [PMID: 11572774]
[http://dx.doi.org/10.1126/science.276.5321.2034] [PMID: 9197264]
[http://dx.doi.org/10.1038/34402] [PMID: 9428761]
[http://dx.doi.org/10.1038/380221a0] [PMID: 8637569]
[http://dx.doi.org/10.1021/bi9816711] [PMID: 9843411]
[http://dx.doi.org/10.1172/JCI90425] [PMID: 27841756]
[http://dx.doi.org/10.1513/pats.200507-066BG] [PMID: 16565424]
[http://dx.doi.org/10.1073/pnas.201289098] [PMID: 11562475]
[http://dx.doi.org/10.1073/pnas.84.24.9265] [PMID: 2827174]
[http://dx.doi.org/10.1096/fj.02-0530fje] [PMID: 12670882]
[http://dx.doi.org/10.1006/niox.1999.0217] [PMID: 10369184]
[http://dx.doi.org/10.1016/S0300-9084(97)82537-0] [PMID: 9010608]
[http://dx.doi.org/10.3109/10715769309145868] [PMID: 8396550]
[http://dx.doi.org/10.1016/S1054-3589(08)61079-0] [PMID: 8562432]
[http://dx.doi.org/10.1073/pnas.93.13.6770] [PMID: 8692893]
[http://dx.doi.org/10.3389/fphys.2018.00125] [PMID: 29520238]
[http://dx.doi.org/10.1007/s00011-006-5195-y] [PMID: 17122956]
[http://dx.doi.org/10.1152/ajpcell.1996.271.5.C1424] [PMID: 8944624]
[http://dx.doi.org/10.1021/jp105606b] [PMID: 21067212]
[http://dx.doi.org/10.1074/jbc.R110.101618] [PMID: 20410298]
[http://dx.doi.org/10.1097/01.shk.0000235141.05528.47] [PMID: 17172974]
[http://dx.doi.org/10.1016/S0005-2728(99)00021-3] [PMID: 10320664]
[http://dx.doi.org/10.1021/bi0509393] [PMID: 16142896]
[http://dx.doi.org/10.1016/j.freeradbiomed.2007.01.007] [PMID: 17349934]
[http://dx.doi.org/10.1074/jbc.M910433199] [PMID: 10906340]
[http://dx.doi.org/10.1074/jbc.275.5.3031] [PMID: 10652282]
[http://dx.doi.org/10.1074/jbc.M910169199] [PMID: 10906338]
[http://dx.doi.org/10.1111/j.1432-1033.1993.tb18091.x] [PMID: 8394811]
[http://dx.doi.org/10.1016/j.biochi.2017.06.006] [PMID: 28619676]
[http://dx.doi.org/10.1074/jbc.M102417200] [PMID: 11395496]
[http://dx.doi.org/10.1016/S0008-6363(01)00445-X] [PMID: 11744025]
[http://dx.doi.org/10.1016/0014-5793(96)00065-8] [PMID: 8641430]
[http://dx.doi.org/10.1016/j.febslet.2008.02.080] [PMID: 18336787]
[http://dx.doi.org/10.1016/j.yjmcc.2007.07.055] [PMID: 17854826]
[http://dx.doi.org/10.1006/abbi.2001.2642] [PMID: 11795892]
[http://dx.doi.org/10.1016/j.bbabio.2004.03.008] [PMID: 15238208]
[http://dx.doi.org/10.1152/ajplegacy.1932.103.1.235]
[PMID: 13654378]
[http://dx.doi.org/10.1016/0014-4827(72)90071-7] [PMID: 4403379]
[http://dx.doi.org/10.1172/JCI106281] [PMID: 4392648]
[http://dx.doi.org/10.1146/annurev.immunol.23.021704.115653] [PMID: 15771570]
[http://dx.doi.org/10.1016/j.jcrc.2014.11.023] [PMID: 25634073]
[http://dx.doi.org/10.7754/Clin.Lab.2016.160504] [PMID: 28164484]
[http://dx.doi.org/10.1056/NEJM197012102832404] [PMID: 5478453]
[http://dx.doi.org/10.1097/SHK.0b013e318181af2a] [PMID: 18704004]
[http://dx.doi.org/10.1016/j.pt.2015.08.001] [PMID: 26440786]
[http://dx.doi.org/10.1007/s12291-012-0187-x] [PMID: 26405393]
[http://dx.doi.org/10.3389/fmicb.2011.00084] [PMID: 21833325]
[http://dx.doi.org/10.1016/j.chom.2013.12.006] [PMID: 24439899]
[http://dx.doi.org/10.1016/j.micpath.2005.11.007] [PMID: 16448800]
[http://dx.doi.org/10.1128/IAI.01063-07] [PMID: 18174337]
[http://dx.doi.org/10.1016/j.chom.2018.04.001] [PMID: 29706505]
[http://dx.doi.org/10.1038/nmicrobiol.2016.224] [PMID: 27892921]
[http://dx.doi.org/10.1093/clinids/21.Supplement_2.S162] [PMID: 8845445]
[http://dx.doi.org/10.1002/wnan.1230] [PMID: 23661566]
[http://dx.doi.org/10.1016/j.freeradbiomed.2017.12.032] [PMID: 29309892]
[http://dx.doi.org/10.1042/BSR20130136] [PMID: 24712762]
[http://dx.doi.org/10.1016/j.yexcr.2004.12.005] [PMID: 15748905]
[http://dx.doi.org/10.4161/cam.4.1.10314] [PMID: 20009568]
[http://dx.doi.org/10.1016/j.bbagen.2012.06.016] [PMID: 22766193]
[http://dx.doi.org/10.1126/science.1092385] [PMID: 15001782]
[http://dx.doi.org/10.1007/s00109-009-0481-0] [PMID: 19444424]
[http://dx.doi.org/10.1038/s41584-018-0039-z] [PMID: 29930301]
[http://dx.doi.org/10.1016/j.autrev.2015.03.002] [PMID: 25797532]
[http://dx.doi.org/10.1146/annurev-immunol-020711-074942] [PMID: 22224774]
[http://dx.doi.org/10.3791/1724] [PMID: 20182410]
[http://dx.doi.org/10.1083/jcb.200606027] [PMID: 17210947]
[http://dx.doi.org/10.1038/nrmicro1710] [PMID: 17632569]
[http://dx.doi.org/10.1126/stke.3792007pe11] [PMID: 17392241]
[http://dx.doi.org/10.1172/JCI84538] [PMID: 27135878]
[http://dx.doi.org/10.7554/eLife.24437] [PMID: 28574339]
[PMID: 9864178]
[http://dx.doi.org/10.1023/A:1024197915723] [PMID: 12815294]
[http://dx.doi.org/10.1016/j.niox.2010.01.001] [PMID: 20060922]
[http://dx.doi.org/10.1189/jlb.1010549] [PMID: 21712395]
[http://dx.doi.org/10.1002/cyto.a.21178] [PMID: 22170804]
[http://dx.doi.org/10.1002/art.38703] [PMID: 24838349]
[http://dx.doi.org/10.1111/j.1398-9995.1980.tb01782.x] [PMID: 6778241]
[http://dx.doi.org/10.4049/jimmunol.1800037] [PMID: 29463689]
[PMID: 826538]
[http://dx.doi.org/10.1073/pnas.76.5.2148] [PMID: 377292]
[http://dx.doi.org/10.1038/286264a0] [PMID: 6250050]
[PMID: 1761571]
[PMID: 8454601]
[http://dx.doi.org/10.1016/j.bbalip.2014.08.012] [PMID: 25152163]
[http://dx.doi.org/10.1016/j.plefa.2016.02.001] [PMID: 27033421]
[http://dx.doi.org/10.1111/j.1432-1033.1987.tb13595.x] [PMID: 2824200]
[http://dx.doi.org/10.1111/j.1432-1033.1989.tb14678.x] [PMID: 2824200]
[http://dx.doi.org/10.1016/j.abb.2010.04.008] [PMID: 2824200]
[http://dx.doi.org/10.1016/j.freeradbiomed.2015.04.015] [PMID: 25912480]
[http://dx.doi.org/10.1016/S0891-5849(00)00512-8] [PMID: 11275470]
[http://dx.doi.org/10.1073/pnas.131128898] [PMID: 11416204]
[http://dx.doi.org/10.1016/S0090-6980(02)00032-1] [PMID: 12432920]
[http://dx.doi.org/10.1089/ars.2017.7155] [PMID: 28699354]
[http://dx.doi.org/10.1016/j.biocel.2010.01.025] [PMID: 20117233]
[http://dx.doi.org/10.1016/j.domaniend.2012.04.005] [PMID: 22608768]
[http://dx.doi.org/10.1111/cea.12990] [PMID: 28763131]
[http://dx.doi.org/10.1080/02770900903056187] [PMID: 19728207]
[PMID: 1326548]
[PMID: 7929234]
[http://dx.doi.org/10.1074/jbc.M206835200] [PMID: 12414804]
[http://dx.doi.org/10.1016/j.jash.2006.11.007] [PMID: 20409830]
[http://dx.doi.org/10.2174/1570161033476718] [PMID: 15320839]
[http://dx.doi.org/10.1023/A:1020718619155] [PMID: 12379824]
[http://dx.doi.org/10.1016/j.mvr.2008.06.001] [PMID: 18616952]
[http://dx.doi.org/10.1016/S0008-6363(02)00786-1] [PMID: 12618242]
[http://dx.doi.org/10.1096/fj.00-0521fje] [PMID: 11099490]
[http://dx.doi.org/10.1186/cc8932] [PMID: 20346119]
[http://dx.doi.org/10.1074/jbc.271.46.29223] [PMID: 8910581]
[http://dx.doi.org/10.1074/jbc.275.13.9369] [PMID: 10734080]
[PMID: 10688604]
[http://dx.doi.org/10.1007/s00109-012-0963-3] [PMID: 23090009]
[http://dx.doi.org/10.1016/j.redox.2015.08.020] [PMID: 26484802]
[http://dx.doi.org/10.1134/S0006297916120154] [PMID: 28259131]
[http://dx.doi.org/10.1186/s12872-018-0757-9] [PMID: 29415653]
[http://dx.doi.org/10.1152/ajpheart.00587.2008] [PMID: 18849334]
[PMID: 15328475]
[http://dx.doi.org/10.1038/sj.bjp.0707393] [PMID: 17641671]
[http://dx.doi.org/10.1371/journal.pone.0070331] [PMID: 23875026]
[http://dx.doi.org/10.1016/S0891-5849(98)00108-7] [PMID: 9801076]
[http://dx.doi.org/10.1016/j.freeradbiomed.2010.08.030] [PMID: 20837134]
[http://dx.doi.org/10.1038/cddis.2016.248] [PMID: 27584786]
[http://dx.doi.org/10.1165/ajrcmb.18.3.2875] [PMID: 9490660]
[http://dx.doi.org/10.1016/j.niox.2005.11.001] [PMID: 16352449]
[http://dx.doi.org/10.1021/tx050146h] [PMID: 16359175]
[http://dx.doi.org/10.1073/pnas.93.5.1753] [PMID: 8700830]
[http://dx.doi.org/10.1152/ajpcell.2000.279.2.C341] [PMID: 10913000]
[http://dx.doi.org/10.1146/annurev.immunol.14.1.649] [PMID: 8717528]
[http://dx.doi.org/10.1146/annurev.immunol.16.1.225] [PMID: 9597130]
[http://dx.doi.org/10.1007/s000110050729] [PMID: 11289659]
[http://dx.doi.org/10.1096/fasebj.9.13.7557017] [PMID: 7557017]
[http://dx.doi.org/10.1016/S0014-5793(97)00623-6] [PMID: 9237665]
[http://dx.doi.org/10.1080/10715760000300511] [PMID: 10798716]
[http://dx.doi.org/10.1385/MN:27:3:325] [PMID: 12845153]
[http://dx.doi.org/10.1146/annurev-pharmtox-010716-105001] [PMID: 28061689]
[http://dx.doi.org/10.1054/bjoc.2000.1367] [PMID: 10970696]
[http://dx.doi.org/10.1158/0008-5472.CAN-04-2212] [PMID: 15520210]
[http://dx.doi.org/10.1038/nri3607] [PMID: 24481336]
[http://dx.doi.org/10.1083/jcb.201004096] [PMID: 20584912]
[http://dx.doi.org/10.1016/j.it.2011.04.009] [PMID: 21782511]
[http://dx.doi.org/10.3389/fcimb.2017.00191] [PMID: 28589095]
[PMID: 10361860]
[http://dx.doi.org/10.4049/jimmunol.1200600] [PMID: 22844112]
[http://dx.doi.org/10.1172/JCI78182] [PMID: 26436651]
![Wayfinder Image](/images/wayfinder.jpg)