Title:Synthesis, Antioxidant and Anti-inflammatory Activities of 5-((styrylsulfonyl) methyl)-1,3,4-Oxadiazol / Thiadiazol-2-amine Derivatives
Volume: 16
Issue: 11
Author(s): Gundala Sravya, Ummadi Nagarjuna, Venkatapuram Padmavathi, Galla Rajitha, Sakuri Chandi priya and Adivireddy Padmaja*
Affiliation:
- Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh,India
Keywords:
Antioxidant activity, anti-inflammatory activity, semicarbazide, thiosemicarbazide, oxadiazole, thiadiazole.
Abstract:
Background: A new class of 5-(styrylsulfonylmethyl)-1,3,4-oxadiazol-2-amine and 5-
(styrylsulfonylmethyl)-1,3,4-thiadiazol-2-amine derivatives were prepared by derivatization of amino
function.
Methods: All the synthesized compounds were tested for antioxidant and anti-inflammatory activities.
Results: The 2-amino-3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-propanamide
(12b) and 3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-butanamide
(14b) displayed significant antioxidant activity, greater than the standard Ascorbic acid.
Conclusion: Moreover, 12b and 14b also exhibited promising anti-inflammatory activity.