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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

NADPH Producing Enzymes as Promising Drug Targets for Chagas Disease

Author(s): Artur T. Cordeiro*

Volume 26, Issue 36, 2019

Page: [6564 - 6571] Pages: 8

DOI: 10.2174/0929867325666181009152844

Price: $65

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Abstract

Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) is a cofactor used in different anabolic reactions, such as lipid and nucleic acid synthesis, and for oxidative stress defense. NADPH is essential for parasite growth and viability. In trypanosomatid parasites, NADPH is supplied by the oxidative branch of the pentose phosphate pathway and by enzymes associated with the citric acid cycle. The present article will review recent achievements that suggest glucose-6-phosphate dehydrogenase and the cytosolic isoform of the malic enzyme as promising drug targets for the discovery of new drugs against Trypanosoma cruzi and T. brucei. Topics involving an alternative strategy in accelerating T. cruzi drug-target validation and the concept of drug-target classification will also be revisited.

Keywords: Malic enzyme, glucose-6-phosphate dehydrogenase, druggability, neglected diseases, NADPH, oxidative stress defense, parasite growth.

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