Abstract
A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus identifying IL-5 as the principal molecular target for therapeutic intervention. This review highlights both the pharmaceutical approaches, and the major challenges, to the identification of small molecule and protein antagonists of the IL-5 receptor. Using examples of known inhibitors we discuss their current status and highlight the major development hurdles in progressing these molecules into the market place.
Keywords: receptor antagonists, granulocyte-macrophage, bronchial hyperreactivity, constrained peptides
Current Pharmaceutical Design
Title: Development of IL-5 Receptor Antagonists
Volume: 8 Issue: 20
Author(s): Iain Uings and Murray McKinnon
Affiliation:
Keywords: receptor antagonists, granulocyte-macrophage, bronchial hyperreactivity, constrained peptides
Abstract: A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus identifying IL-5 as the principal molecular target for therapeutic intervention. This review highlights both the pharmaceutical approaches, and the major challenges, to the identification of small molecule and protein antagonists of the IL-5 receptor. Using examples of known inhibitors we discuss their current status and highlight the major development hurdles in progressing these molecules into the market place.
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Cite this article as:
Uings Iain and McKinnon Murray, Development of IL-5 Receptor Antagonists, Current Pharmaceutical Design 2002; 8 (20) . https://dx.doi.org/10.2174/1381612023393800
DOI https://dx.doi.org/10.2174/1381612023393800 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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