Title:The Several Activities of 4 - Methyl Pyrazole in Animals and Humans
Volume: 24
Issue: 18
Author(s): Gaetano Iaquinto*
Affiliation:
- Gastroenterology and Digestive Endoscopy Service, S. Rita Clinic, via Appia, 83042, Atripalda,Italy
Keywords:
4 methyl pyrazole, alchol gastric, mucosal injury, gastroprotection, ADH, ethanol, alcohol.
Abstract: 4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than
toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene
glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective
effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first
time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal
injury.