Review Article

金属蛋白酶抑制剂在中枢神经系统疾病治疗中的观点和新方面:从化学到医学

卷 26, 期 18, 2019

页: [3208 - 3224] 页: 17

弟呕挨: 10.2174/0929867325666180514111500

价格: $65

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摘要

基质金属蛋白酶(MMP)在细胞外基质(ECM)的重塑中起关键作用,同时影响细胞分化,迁移,增殖和存活。 在许多人类疾病(包括癌症,类风湿性关节炎,肺气肿和纤维化疾病)中,它们的重要性已为人所知,但应特别注意MMP在中枢神经系统(CNS)疾病中的作用。 到目前为止,大脑中尚无许多有据可查的生理MMP目标蛋白,只有一些病理性蛋白。 许多神经退行性疾病是脑ECM重塑的结果或导致其紊乱,因此MMP的正确作用及其活性的控制可能在这些疾病的发展中起关键作用。 在本综述中,我们讨论金属蛋白酶抑制剂的作用,从著名的金属蛋白酶天然内源性组织抑制剂(TIMPs)到外源性合成抑制剂,如(4-苯氧基苯基磺酰基)甲基噻吩烷(SB-3CT),四环素,巴马司他(BB-94) )和FN-439。 由于已经在生理发育以及主要在赘生性疾病的病理状况中很好地描述了MMP-TIMP系统,因此在这种情况下,关于哺乳动物脑组织中酶系统的知识仍然知之甚少。 因此,我们专注于在成年大脑的生理功能以及包括神经退行性疾病,脑损伤等在内的病理状况中抑制MMPs。

关键词: 中枢神经系统疾病,MMPs抑制,脑,金属蛋白酶,赘生性疾病,TIMPs。

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