Title:Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases
Volume: 24
Issue: 12
Author(s): Guilherme Felipe dos Santos Fernandes, Aline Renata Pavan and Jean Leandro dos Santos*
Affiliation:
- Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara,Brazil
Keywords:
Heterocyclic N-oxides, N-oxide compounds, tuberculosis, malaria, neglected tropical diseases, leishmaniasis, Chagas disease,
drug discovery.
Abstract: Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders,
especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal
chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity
against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of
heterocyclic N-oxides are described herein, nevertheless, the following chemical classes deserve to be highlighted
due to a large number of reports in the literature about their promising pharmacological effects: furoxan,
benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide. In order to describe
those most promising compounds, we included in this review only those most biologically active heterocyclic Noxide
published since 2000.