Title:Evaluation of the Antidiabetic Property of Capparis Ovata Desf. Var. Palaestina Zoh. Extracts Using In vivo and In vitro Approaches
Volume: 18
Issue: 5
Author(s): Mehmet E. Okur*, Derya C. Polat, Hanefi Ozbek, Sezen Yilmaz, Aysegul Yoltas and Rana Arslan
Affiliation:
- Department of Pharmacology, Istanbul Medipol University, School of Pharmacy, Istanbul,Turkey
Keywords:
Diabetes mellitus, C. ovata var. palaestina, hypoglycemic effect, antioxidant, antimicrobial, hyperglycemia.
Abstract: Background and Objective: This paper is focused on evaluating the various biological activities
of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications.
Methods: Alloxan-induced diabetic BALB-c mice were administered intraperitoneally with 100, 300,
500mg/kg doses of ethanol and aqueous extracts of buds and fruits. Furthermore, HPLC, phenolic and
flavonoid compounds analysis, ABTS and DPPH free radical scavenging activity, anti-inflammatory
activity, agar well diffusion and MIC tests were carried out.
Results: Fruit-aqueous; 100mg/kg, 300mg/kg and bud-aqueous; 500mg/kg extracts showed significant
hypoglycemic activity. All extracts indicated important antioxidant activity, however, bud-aqueous
extract demonstrated the most potent activity. HPLC study exhibited that rutin is found in high
amounts in bud-aqueous and bud-ethanol extracts. Furthermore, the bud-aqueous extract depicted
stronger and broader antimicrobial activity than other extracts. Fruit-ethanol and bud-ethanol extracts
denoted the most potent anti-inflammatory effect even though this effect was significantly shown by
all extracts. Finally, high levels of phenolic and flavonoid content were involved in all extracts, but the
highest levels were found in fruit-ethanol and bud-ethanol extracts.
Conclusion: The results showed that extracts which indicated hypoglycemic, antioxidant, antiinflammatory,
antimicrobial activities may provide a valuable contribution to the management of diabetes
and its complications.
