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摘要
在急性心肌梗死(AMI)中,第一道治疗方法是迅速恢复缺血心肌的血流量,以限制梗死范围。现在已经确定,虽然这种干预是明显有益的,但除了先前的缺血外,这种干预的积极结果还受到再灌注本身的损伤的限制。这一过程被描述为再灌注损伤,并被认为是导致心律失常、微血管功能障碍和心脏收缩功能受损的原因之一,即使在冠脉血流恢复后也是如此。因此,一个重要的,目前尚未解决的治疗挑战是如何处理这种再灌注损伤的结果。本文综述了黄酮类化合物和黄酮类化合物对缺血再灌注心脏功能的保护作用,并对其可能的机制进行了探讨,特别是对激酶的抑制作用。
关键词: 抗氧化剂,心脏保护,缺血-再灌注,活性氧,黄酮,黄酮醇,激酶。
Current Medicinal Chemistry
Title:Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases
Volume: 25 Issue: 34
关键词: 抗氧化剂,心脏保护,缺血-再灌注,活性氧,黄酮,黄酮醇,激酶。
摘要: In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now well established that though clearly beneficial, the positive outcomes of this intervention are limited by injury in response to the reperfusion itself in addition to the prior ischemia. This process is described as reperfusion injury and is considered to contribute to the arrhythmias, microvascular dysfunction and impaired cardiac contractility that is observed even after the restoration of coronary blood flow. Thus an important, currently unmet, therapeutic challenge is to address the outcomes of this reperfusion injury. In this article, we review the evidence that flavonols and flavones may prove useful in preserving cardiac function after ischemia and reperfusion and consider the possible mechanisms, in particular, the inhibition of kinases, by which they may exert protection.
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Cite this article as:
Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867325666180326161730
DOI https://dx.doi.org/10.2174/0929867325666180326161730 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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