Title:Biomarkers Insights in Psoriasis - Regulatory Cytokines
Volume: 7
Issue: 1
Author(s): Mihaela Surcel, Radu Huica, Carolina Constantin, Cornel Ursaciuc and Monica Neagu*
Affiliation:
- Immunology Department, ,Romania
Keywords:
Autoimmunity, biomarkers, chemokines, cytokines, psoriasis, Th17.
Abstract: The psoriatic disease has a multi-factorial determinism being generated by a complex array
of genetic, immunologic, and environmental factors. In this array, cellular interplay takes place maintaining
the epidermal equilibrium. Psoriasis pathophysiology is characterized by keratinocytes hyperproliferation
and immune cell infiltration in the dermis and epidermis. Innate and adaptive immune
cells are highly involved, the main cellular players being dendritic and T lymphocytes, among other
cells. Th17-type cytokines (e.g.,, IL-17A, IL-17F, IL-22, IL-21) as regulatory are at the core of psoriasis
pathogenesis. Cytokines that emerge due to the activation of lymphocytes maintain a chronic inflammatory
response acknowledged in the psoriatic skin. In vivo and in vitro cellular models, along
with clinical trials that acknowledge cytokines as biomarkers and therapy targets are presented.
