Review Article

功能失调性高密度脂蛋白作为动脉粥样硬化预防的治疗靶点

卷 26, 期 9, 2019

页: [1610 - 1630] 页: 21

弟呕挨: 10.2174/0929867325666180316115726

价格: $65

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摘要

高胆固醇血症是动脉粥样硬化发生的主要危险因素之一。然而,在各种脂蛋白类别中,高密度脂蛋白(HDL)与动脉粥样硬化发生率呈负相关,因为它们能够发挥一系列的动脉粥样硬化保护功能。高密度脂蛋白在逆转胆固醇转运、抗氧化和抗炎特性以及维持内皮内稳态的能力中的核心作用可能是高密度脂蛋白介导的动脉粥样硬化保护的原因。然而,有效提高高密度脂蛋白胆固醇的药物并不能降低心血管事件的发生率,这表明血浆中高密度脂蛋白胆固醇水平和高密度脂蛋白功能并不总是相关的。有几个证据表明,不同的病理状况,特别是与炎症反应相关的病理状况,可以引起HDL蛋白和脂质的急剧变化,导致HDL功能障碍。设计用于影响脂质代谢和增加HDL-C的既有药物和研究药物在纠正HDL功能障碍方面仅部分有效。

关键词: 高密度脂蛋白,动脉粥样硬化,冠心病,慢性肾病,糖尿病,自身免疫性疾病,炎症。

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