Title:Protein Tyrosine Nitration in Lung Cancer: Current Research Status and Future Perspectives
Volume: 25
Issue: 29
Author(s): Xianquan Zhan*, Yuda Huang and Shehua Qian
Affiliation:
- Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008,China
Keywords:
Lung cancer, tyrosine nitration, nitroproteomics, mass spectrometry, systems biology, structural biology.
Abstract: Oxidative/nitrative damage is a crucial element among the complex factors that
contribute to lung carcinogenesis. Nitric oxide (NO) free radicals, through chemical modifications
such as tyrosine nitration, are significantly involved in lung carcinogenesis and metastasis.
NO-mediated protein nitration, which is the addition of the nitro group (–NO2) to position
3 of the phenolic ring of a tyrosine residue, is an important molecular event in lung cancer,
and has been studied with mass spectrometry. Nitration is involved in multiple biological
processes, including signal transduction, protein degradation, energy metabolism, mitochondrial
dysfunction, enzyme inactivation, immunogenic response, apoptosis, and cell death. This
article reviews the relationship of NO and its derivates and lung cancer, formation and roles
of tyrosine nitration in lung cancer, differences of protein nitration between lung cancer and
other inflammatory pulmonary diseases, current status of protein nitration and nitroproteomics
in lung cancer, and future perspectives to achieve a better understanding of lung carcinogenesis,
for biomarker discovery; and for new diagnostic and prognostic monitoring, and therapeutic
targets.
