Review Article

ABC转运蛋白在兽医学中的作用:药理毒理学意义

卷 26, 期 7, 2019

页: [1251 - 1269] 页: 19

弟呕挨: 10.2174/0929867325666180201094730

价格: $65

摘要

与医生不同,兽医从业者必须处理一些在解剖学,生理学和新陈代谢方面具有重要差异的动物物种。因此,药物的药代动力学行为,临床功效和药物的不良或毒性作用可能因家畜而异。此外,由于在食用产品中产生化学残留物,在食品生产物种中使用药物可能对人类构成风险,这是公共健康和消费者安全的主要问题。如在人类中清楚地已知的,转运蛋白的ATP结合盒(ABC)也可以影响家畜中的许多药物和其他异生素的生物利用度和消除。目前在兽医市场上可获得的许多药物是一种或多种转运蛋白的底物。因此,ABC底物之间显着的药物 - 药物相互作用可能在不同的兽医物种中具有不可预测的药物毒性后果。在这种情况下,不同的研究揭示了P-gp和其他转运蛋白,如乳腺癌耐药蛋白(BCRP)和多药耐药相关蛋白(MRPs)在伴侣和家畜中的主要相关性。毫无疑问,ABC转运蛋白的发现以及对它们在不同物种中的生理作用的深刻理解为兽医药理学引入了新的范例。本综述着重于兽医感兴趣的物种中表达的主要转运蛋白的表达和功能,以及它们对药物处置,功效和毒性的影响。

关键词: ATP结合盒转运蛋白,P-糖蛋白,乳腺癌耐药蛋白,多药耐药相关蛋白,异生物转运,家畜。

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