Title:Colchicine in Renal Diseases: Present and Future
Volume: 24
Issue: 6
Author(s): Smaragdi Marinaki, Chrysanthi Skalioti and J.N. Boletis*
Affiliation:
- National and Kapodistrian University of Athens, Medical School, Nephrology Department and Renal Transplantation Unit, Laiko Hospital Athens, Athens,Greece
Keywords:
Colchicine, chronic kidney disease, fibrosis, inflammation, lipophilic alkaloid, gouty arthritis.
Abstract: Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties.
Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of
neutrophil adhesion and recruitment.
Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this
review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease
entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main
interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients
with reduced glomerular filtration rate.
