Title:Synthesis and Bioevaluation of Shikonin Derivatives
Volume: 15
Issue: 9
Author(s): Sufen Cao, Jiangang Zhang and Wenhu Duan*
Affiliation:
- Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai,China
Keywords:
Amidation, chemical stability, cytotoxicity, esterification, shikonin derivatives, synthesis, SRB assay, cell lines.
Abstract: Background: Ester and amide derivatives of shikonin were synthesized to improve the
chemical stability of shikonin.
Methods: All synthesized compounds were evaluated for their antiproliferative activity against
A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin.
Results and Conclusion: The most potent compound, 22d, was more stable and potent than
shikonin.