Title:New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
Volume: 26
Issue: 22
关键词:
脂肪因子,糖尿病,2型糖尿病,胰岛素抵抗,肥胖症,葡萄糖代谢。
摘要: A large number of studies have been focused on investigating serum biomarkers
associated with risk or diagnosis of type-2 diabetes mellitus. In the last decade, promising
studies have shown that circulating levels of adipokines could be used as a relevant biomarker
for diabetes mellitus progression as well as therapeutic future targets. Here, we discuss the
possible use of recently described adipokines, including apelin, omentin-1, resistin, FGF-21,
neuregulin-4 and visfatin, as early biomarkers for diabetes. In addition, we also include recent
findings of other well known adipokines such as leptin and adiponectin. In conclusion, further
studies are needed to clarify the pathophysiological significance and clinical value of these
biological factors as potential biomarkers in type-2 diabetes and related dysfunctions.