Title:Amino Acid Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives
Volume: 15
Issue: 4
Author(s): K. Mohammed Mustaque, A. Subramani, T.K. Shabeer, H. Thajudeen and V.S. Jamal Ahamed*
Affiliation:
- PG and Research Dept. of Chemistry, The New College, Chennai-600014, Tamilnadu,India
Keywords:
Amino acid, catalyst, 2, 3-Dihydroquinazolin-4(1H)-ones, 2-aminobenzamide, ketones, water.
Abstract: A simple, convenient and facile approach for the synthesis of a series of 2,3-
dihydroquinazolin-4(1H)-ones in an environmentally benign method has been developed. This method
involves a direct cyclocondensation of 2-aminobenzamide with aromatic aldehydes and ketones using
aspartic acid as a catalyst in water.