Abstract
Clara cell 10-kDa protein (CC10) / uteroglobin (UG) is a nonglycoprotein with a molecular mass of 16 kilodaltons, which is produced by mucosal epithelial cells in the lung (Clara cells), uterus and prostate. Like other low molecular weigh proteins it is catabolized in renal proximal tubules. Structurally it is a homodimer of subunits of 70 amino acids covalently bound in an antiparallel manner. It belongs to secretogobin (SCGB) family and is assigned as subgroup 1A1. The function of the protein so far elucidated is immunoregulatory and anti-inflammatory in innate immunity. The knockout mouse of UG gene resulted in aggravation of inflammation by allergic and hyperoxic stimuli. It also showed very similar pathological features with human IgA nephropathy. The value is changed in the lung fluid and serum of various inflammatory and allergic lung diseases. Several kinds of single nucleotide polymorphisms (SNPs) in human CC10 / UG gene were recently discovered, Adenine allele accumulation in G38A SNP has possible association with asthma and IgA nephropathy, being paralleled with disease severity of IgA nephropathy. Its expression is enhanced by some transcriptional factors induced by cytokines such as interferon-γ. For cancer cells, the protein functions as an antagonist of neoplastic phenotype. CC10 / UG forms one of intra- and intercellular regulators involved in inflammation and malignant transformation in the respiratory and urogenital fields.
Keywords: clara cell 10-kda protein, uteroglobin, protein 1, secretoglobin, inflammatory lung diseases, Iga nephropathy, single nucleotide polymorphism
Current Pharmaceutical Design
Title: Clinical Aspects of Clara Cell 10-kDa Protein / Uteroglobin (Secretoglobin 1A1)
Volume: 9 Issue: 14
Author(s): Noriharu Shijubo, Isao Kawabata, Noriyuki Sato and Yoshihisa Itoh
Affiliation:
Keywords: clara cell 10-kda protein, uteroglobin, protein 1, secretoglobin, inflammatory lung diseases, Iga nephropathy, single nucleotide polymorphism
Abstract: Clara cell 10-kDa protein (CC10) / uteroglobin (UG) is a nonglycoprotein with a molecular mass of 16 kilodaltons, which is produced by mucosal epithelial cells in the lung (Clara cells), uterus and prostate. Like other low molecular weigh proteins it is catabolized in renal proximal tubules. Structurally it is a homodimer of subunits of 70 amino acids covalently bound in an antiparallel manner. It belongs to secretogobin (SCGB) family and is assigned as subgroup 1A1. The function of the protein so far elucidated is immunoregulatory and anti-inflammatory in innate immunity. The knockout mouse of UG gene resulted in aggravation of inflammation by allergic and hyperoxic stimuli. It also showed very similar pathological features with human IgA nephropathy. The value is changed in the lung fluid and serum of various inflammatory and allergic lung diseases. Several kinds of single nucleotide polymorphisms (SNPs) in human CC10 / UG gene were recently discovered, Adenine allele accumulation in G38A SNP has possible association with asthma and IgA nephropathy, being paralleled with disease severity of IgA nephropathy. Its expression is enhanced by some transcriptional factors induced by cytokines such as interferon-γ. For cancer cells, the protein functions as an antagonist of neoplastic phenotype. CC10 / UG forms one of intra- and intercellular regulators involved in inflammation and malignant transformation in the respiratory and urogenital fields.
Export Options
About this article
Cite this article as:
Shijubo Noriharu, Kawabata Isao, Sato Noriyuki and Itoh Yoshihisa, Clinical Aspects of Clara Cell 10-kDa Protein / Uteroglobin (Secretoglobin 1A1), Current Pharmaceutical Design 2003; 9 (14) . https://dx.doi.org/10.2174/1381612033455026
DOI https://dx.doi.org/10.2174/1381612033455026 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employ in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, prediction, to monitor of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Interleukin 1-beta is Linked to Chronic Low-Grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents
Endocrine, Metabolic & Immune Disorders - Drug Targets Current Concept in the Treatment of Atopic Dermatitis
Recent Patents on Inflammation & Allergy Drug Discovery Locked Nucleic Acids (LNA): Versatile Tools for Designing Oligonucleotide Decoys with High Stability and Affinity
Current Drug Targets Use of the Adamantane Structure in Medicinal Chemistry
Current Medicinal Chemistry Should we Target Allergen Protease Activity to Decrease the Burden of Allergic Airway Inflammation?
Inflammation & Allergy - Drug Targets (Discontinued) New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia
Current Cancer Drug Targets Mechanisms of Er Chen Tang on Treating Asthma Explored by Network Pharmacology and Experimental Verification
Combinatorial Chemistry & High Throughput Screening Is There Anybody in There? On The Mechanisms of Wall Crossing of Cell Penetrating Peptides
Current Protein & Peptide Science Bronchial Asthma and Mucociliary Clearance - A Bidirectional Relationship
Current Respiratory Medicine Reviews Effects of a Novel Barley-Based Formulation on Allergic Rhinitis: A Randomized Controlled Trial
Endocrine, Metabolic & Immune Disorders - Drug Targets Autonomic Nervous System in Viral Myocarditis: Pathophysiology and Therapy
Current Pharmaceutical Design Caffeic Acid, A Versatile Pharmacophore: An Overview
Mini-Reviews in Medicinal Chemistry Complex Effect of Adenovirus Early Region Proteins on Innate Immune System
Inflammation & Allergy - Drug Targets (Discontinued) Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria
Current Drug Targets Anti-inflammatory Potential of Alkaloids as a Promising Therapeutic Modality
Letters in Drug Design & Discovery Is α7-nAChR a Possible Target for Lung Cancer and Malignant Pleural Mesothelioma Treatment?
Current Drug Targets Bronchial Epithelial Cells in Allergic Reactions
Current Drug Targets - Inflammation & Allergy Recent Insights into COVID-19 in Children and Clinical Recommendations
Current Pediatric Reviews Role of Vitamin D in Vascular Complications and Vascular Access Outcome in Patients with Chronic Kidney Disease
Current Medicinal Chemistry Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
Current Topics in Medicinal Chemistry