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摘要
遗传背景仅占帕金森病(PD)报告病例的5%至10%,其余病例病因不明。人们认为环境因素可能是因变量。很大一部分PD病例的因果关系。许多PD基因被异生物暴露激活,农药暴露与PD之间存在联系。许多流行病学l研究表明,钯与汞、铅、锰、铜、铁、铝、铋、铊和锌等金属接触有关联。本文综述了生物效应的研究进展。、致病过程、对金属的遗传敏感性以及对未来PD治疗策略的研究,如螯合治疗。
关键词: 黑质,α-突触素,β-淀粉样蛋白,谷氨酸,谷胱甘肽,氧化应激,金属,多巴胺
Current Medicinal Chemistry
Title:Metals and Parkinson's Disease: Mechanisms and Biochemical Processes
Volume: 25 Issue: 19
关键词: 黑质,α-突触素,β-淀粉样蛋白,谷氨酸,谷胱甘肽,氧化应激,金属,多巴胺
摘要: Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.
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Cite this article as:
Metals and Parkinson's Disease: Mechanisms and Biochemical Processes, Current Medicinal Chemistry 2018; 25 (19) . https://dx.doi.org/10.2174/0929867325666171129124616
DOI https://dx.doi.org/10.2174/0929867325666171129124616 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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