Review Article

代谢组学与心脏病:从基础到临床

卷 26, 期 1, 2019

页: [46 - 59] 页: 14

弟呕挨: 10.2174/0929867324666171006151408

价格: $65

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摘要

背景:在过去的15年里,代谢组学领域的规模一直在稳步增长。分析和统计方法的进步使代谢组学在医学的各个领域蓬勃发展。心血管疾病是代谢组学的主要研究对象之一,由于其社会和医学上的相关性,以及代谢改变在其发病机制和进化过程中所起的重要作用。代谢组学已应用于心血管疾病的全谱研究:从患者风险分层到心肌梗死和心力衰竭。然而,尽管有许多关于代谢组学在心血管疾病诊断、预后和治疗评估中的适用性的概念验证研究,但它还没有用于常规临床实践。近年来,在临床环境中建立了大型的现象中心,有望为代谢组学在临床实践中的适用性提供决定性的证据。但中小型中心也有空间处理罕见的病理或解决特定但相关的临床问题。 目的:在本文中,我们将介绍代谢组学,介绍迄今为止在心血管疾病领域所做的代谢组学工作。 结论:心血管领域已处于代谢组学应用的前沿,应在不久的将来将其引入临床。

关键词: 代谢分析,代谢组学,心血管疾病,核磁共振氢谱,代谢表型,精密医学。

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