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摘要
多酚是一类水溶性有机化合物,主要来源于天然.具有5~7个芳香环和超过12个酚羟基的化合物被归类为多酚类化合物。这些是抗氧化剂,保护身体免受氧化损伤。在植物中,它们是作为抵御胁迫因子的防御机制而产生的次生代谢物。多酚类化合物的抗氧化性能被认为可以预防与活性氧(ROS)相关的多种疾病,包括癌症。世界各地开展的各种研究表明,多酚类化合物可以抑制肿瘤的发生,诱导癌细胞凋亡,并干扰肿瘤的进展。这组神奇化合物存在于天然植物和食品中。通过饮食摄入多酚可以清除活性氧,从而有助于预防癌症。该植物衍生产品也可与常规化疗一起使用,以提高化学预防效果。本综述的重点是各种体外和体内的研究,以评估在我们的食物中存在的多酚类物质的抗癌潜力。此外,还讨论了多酚类化合物(黄酮类、木质素类、二苯乙烯类和酚酸类)对癌症的化学预防作用所涉及的途径。
关键词: 多酚,癌症化学预防,凋亡,黄酮,酚酸,致癌,木质素。
Current Medicinal Chemistry
Title:Polyphenols in Food: Cancer Prevention and Apoptosis Induction
Volume: 25 Issue: 36
关键词: 多酚,癌症化学预防,凋亡,黄酮,酚酸,致癌,木质素。
摘要: Polyphenols are a group of water-soluble organic compounds, mainly of natural origin. The compounds having about 5-7 aromatic rings and more than 12 phenolic hydroxyl groups are classified as polyphenols. These are the antioxidants which protect the body from oxidative damage. In plants, they are the secondary metabolites produced as a defense mechanism against stress factors. Antioxidant property of polyphenols is suggested to provide protection against many diseases associated with reactive oxygen species (ROS), including cancer. Various studies carried out across the world have suggested that polyphenols can inhibit the tumor generation, induce apoptosis in cancer cells and interfere in progression of tumors. This group of wonder compounds is present in surplus in natural plants and food products. Intake of polyphenols through diet can scavenge ROS and thus can help in cancer prevention. The plant derived products can also be used along with conventional chemotherapy to enhance the chemopreventive effects. The present review focuses on various in vitro and in vivo studies carried out to assess the anti-carcinogenic potential of polyphenols present in our food. Also, the pathways involved in cancer chemopreventive effects of various subclasses (flavonoids, lignans, stilbenes and phenolic acids) of polyphenols are discussed.
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Cite this article as:
Polyphenols in Food: Cancer Prevention and Apoptosis Induction, Current Medicinal Chemistry 2018; 25 (36) . https://dx.doi.org/10.2174/0929867324666171006144208
DOI https://dx.doi.org/10.2174/0929867324666171006144208 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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