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摘要
癌症治疗仍然是一个挑战,因为目前使用的化疗药物的几个限制,如其不良的药代动力学,不利的化学性质,以及无法区分健康和疾病的组织。纳米技术为克服这些限制提供了有力的工具。(2)改善水溶性差的药物的理化性质,如紫杉醇;(3)选择性地将化疗药物运送到肿瘤病灶,从而减少非靶点的毒性,并促进细胞内的内化。为了实现这一目的,已经制定了几项战略,这些战略是基于在当地和系统地发生的因肿瘤发生而发生的生物和物理变化而制定的。在这里,我们将讨论炎症在肿瘤发展的不同阶段中的作用,以及利用纳米粒子开发炎症途径的策略,以便选择性地将肿瘤相关的微环境作为治疗和诊断的目标。
关键词: 纳米医学,仿生纳米粒子,炎症,活性靶向,癌症,热疗,发炎血管。
Current Medicinal Chemistry
Title:Inflammation and Cancer: In Medio Stat Nano
Volume: 25 Issue: 34
关键词: 纳米医学,仿生纳米粒子,炎症,活性靶向,癌症,热疗,发炎血管。
摘要: Cancer treatment still remains a challenge due to the several limitations of currently used chemotherapeutics, such as their poor pharmacokinetics, unfavorable chemical properties, as well as inability to discriminate between healthy and diseased tissue. Nanotechnology offered potent tools to overcome these limitations. Drug encapsulation within a delivery system permitted i) to protect the payload from enzymatic degradation/ inactivation in the blood stream, ii) to improve the physicochemical properties of poorly water-soluble drugs, like paclitaxel, and iii) to selectively deliver chemotherapeutics to the cancer lesions, thus reducing the off-target toxicity, and promoting the intracellular internalization. To accomplish this purpose, several strategies have been developed, based on biological and physical changes happening locally and systemically as a consequence of tumorigenesis. Here, we will discuss the role of inflammation in the different steps of tumor development and the strategies based on the use of nanoparticles that exploit the inflammatory pathways in order to selectively target the tumor-associated microenvironment for therapeutic and diagnostic purposes.
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Cite this article as:
Inflammation and Cancer: In Medio Stat Nano, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867324666170920160030
DOI https://dx.doi.org/10.2174/0929867324666170920160030 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
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Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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