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摘要
背景:PET和SPECT显像方法可以为纳米药物缓释系统的开发提供很好的帮助,同时,这些研究也为生产特殊的新型诊断和治疗放射性药物提供了机会。有了多功能、纳米尺度的药物传递系统,诊断(成像)方法和治疗(提供药物或β发射放射性核素)可以使用相同的生物和药理学机制进行。通过在一种方法或一种特定靶向纳米粒子系统中结合治疗和诊断,我们可以生产热敏药物,其应用是个性化医学的重要组成部分。目的:简要回顾放射性核素(放射标记)纳米粒子的前身放射性固体,然后描述目前PET和SPECT显像相关纳米粒子产品的一般特征和关键的放射性标记方法,并详细介绍与放射治疗方法和影像引导治疗有关的潜在挑战。
关键词: PET,SPECT,纳米医学,纳米粒子,热疗法,个性化医学。
Current Medicinal Chemistry
Title:Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics
Volume: 25 Issue: 34
关键词: PET,SPECT,纳米医学,纳米粒子,热疗法,个性化医学。
摘要: Background: PET and SPECT imaging methods can be of excellent assistance for the development of new nanoparticle drug delivery systems, and at the same time, these investigations also offer the opportunity to produce exceptional new diagnostic and therapeutic radiopharmaceuticals, as well.
With a multifunctional, nano-scaled drug delivery system, the diagnostic (imaging) methods and the therapy (delivering drugs or beta-emitter radionuclides) can be carried out using the same biological and pharmacological mechanisms. By combining therapy and diagnostics in one method or in one specifically targeted nanoparticle system, we can product theranostic pharmaceuticals, and its applications are important elements of personalized medicine.
Objectives: This review takes a short historical look back to the radiocolloids, the great ancestors of (radiolabeled) nanoparticles and then describes the general features of current types of PET and SPECT imaging associated nanoparticle-based products and key radiolabeling methods; entering into details of potential prospective challenges related to radiotheranostic approaches and imaging guided therapy.
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Cite this article as:
Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867324666170830095553
DOI https://dx.doi.org/10.2174/0929867324666170830095553 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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