Title:Graphene-Based Nanomaterials: Potential Tools for Neurorepair
Volume: 24
Issue: 1
Author(s): Qing Wang, Yan-Hua Li, Wei-Jia Jiang, Jian-Guo Zhao, Bao-Guo Xiao, Guang-Xian Zhang*Cun-Gen Ma*
Affiliation:
- Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107,United States
- "2011" Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan,China
Keywords:
Graphene, neural cells, biocompatibility, biological activity, neurodegeneration, drug carrier.
Abstract: Graphene, with its outstanding electrical properties, large surface area, and excellent mechanical properties,
is found in a wide variety of applications in biomimetic substrates and biomedicine, with the result that
there is growing interest in the effect of graphene-based nanomaterials on neural cells. This review sums up current
research on the effectiveness of graphene and its derivatives on neural cells. We emphasize the biocompatibility
of graphene and its derivatives, and how they affect the behavior of neural cells, including adhesion, proliferation,
neurite outgrowth and differentiation. In addition, we discuss at great length the literature on graphenebased
nanomaterials for drug delivery applications. While their in vivo effects on the nervous system remain to be
explored, encouraging findings indicate that graphene-based nanomaterials have significant potential as novel
therapies for neurodegenerative disease.
