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摘要
背景:可见光被色素和非色素哺乳动物细胞中的光受体吸收,激活信号级联和下游机制,导致细胞过程的调节。大多数研究都研究了紫外光谱和红外光到近红外光谱的分子机制和治疗应用。对于光谱中不含紫外线的蓝色部分,人们付出的努力要少得多。 目的:本文就炎症性皮肤条件下非视觉哺乳动物细胞蓝光受体的分子光受体、信号传导机制及相应的治疗机会的研究进展进行综述。方法:对文献进行扫描,以获取有关蓝光分子机制、细胞效应和治疗应用的同行评论文章。 结果:在分子水平上,蓝光被黄素、卟啉、亚硝化蛋白和视蛋白吸收,诱导活性氧的生成、一氧化氮的释放和G蛋白偶联信号的激活。关于蓝光诱导信号传导的细胞效应,报道的结果有限且具有对比性。一些研究描述了增殖和分化的调节或炎症参数的调节;另一些研究显示生长抑制和凋亡。不管其潜在机制如何,临床研究表明蓝光有助于治疗炎症性皮肤病。 结论:为了加强蓝光在治疗中的应用,对蓝光潜在的分子和细胞机制及其转化为临床应用进行深入研究是十分必要的。
关键词: 光疗、蓝光、活性氧、一氧化氮、S-亚硝基化信号、视蛋白、皮肤细胞、炎症性皮肤状况
Current Medicinal Chemistry
Title:Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities
Volume: 25 Issue: 40
关键词: 光疗、蓝光、活性氧、一氧化氮、S-亚硝基化信号、视蛋白、皮肤细胞、炎症性皮肤状况
摘要: Background: Visible light is absorbed by photoacceptors in pigmented and non-pigmented mammalian cells, activating signaling cascades and downstream mechanisms that lead to the modulation of cellular processes. Most studies have investigated the molecular mechanisms and therapeutic applications of UV and the red to near infrared regions of the visible spectrum. Considerably less effort has been dedicated to the blue, UV-free part of the spectrum.
Objective: In this review, we discuss the current advances in the understanding of the molecular photoacceptors, signaling mechanisms, and corresponding therapeutic opportunities of blue light photoreception in non-visual mammalian cells in the context of inflammatory skin conditions.
Methods: The literature was scanned for peer-reviewed articles focusing on the molecular mechanisms, cellular effects, and therapeutic applications of blue light.
Results: At a molecular level, blue light is absorbed by flavins, porphyrins, nitrosated proteins, and opsins; inducing the generation of ROS, nitric oxide release, and the activation of G protein coupled signaling. Limited and contrasting results have been reported on the cellular effects of blue light induced signaling. Some investigations describe a regulation of proliferation and differentiation or a modulation of inflammatory parameters; others show growth inhibition and apoptosis. Regardless of the elusive underlying mechanism, clinical studies show that blue light is beneficial in the treatment of inflammatory skin conditions.
Conclusion: To strengthen the use of blue light for therapeutic purposes, further in depth studies are clearly needed with regard to its underlying molecular and cellular mechanisms, and their translation into clinical applications.
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Cite this article as:
Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170727112206
DOI https://dx.doi.org/10.2174/0929867324666170727112206 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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