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摘要
背景和理论基础:治疗性药物监测(TDM)是一种在指定的时间间隔内测量患者体内药物浓度的临床实践。这种做法允许在与毒性有关的问题和(或)调整剂量以更好地满足治疗需求的情况下进行迅速的医疗干预。目前,TDM是在中央实验室进行的,使用的仪器,如免疫分析法和质谱仪,只能由训练有素的人员操作。然而,准备、样品分析和数据处理所需的时间,以及相关的财务费用,严重影响了TDM在医疗实践中的应用。因此,有必要建立新一代的分析工具,以及时满足给药或减少药物的需求,从而有效地治疗肿瘤患者。审查的目的:TDM的最新技术:纳米科学和生物传感器领域的技术进步为解决这些问题提供了独特的机会。所谓的纳米生物传感器的兴趣正在显著增加,特别是在药物发现和临床化学方面,尽管只有很少的例子报告了它们在tdm中的应用。采用纳米传感器的技术主要是基于电化学、光学和质量检测系统。结论:在这篇综述中,我们描述了最有希望的方法,在我们看来,这些方法将使tdm在未来的临床实践中进入下一阶段。
关键词: 生物传感器,治疗药物监测,抗癌,电化学,护理点,表面等离子体共振,光谱,受体。
Current Medicinal Chemistry
Title:Biosensing Technologies for Therapeutic Drug Monitoring
Volume: 25 Issue: 34
关键词: 生物传感器,治疗药物监测,抗癌,电化学,护理点,表面等离子体共振,光谱,受体。
摘要: Background and Rationale: Therapeutic drug monitoring (TDM) is the clinical practice of measuring pharmaceutical drug concentrations in patients’ biofluids at designated intervals to allow a close and timely control of their dosage. This practice allows for rapid medical intervention in case of toxicity-related issues and/or adjustment of dosage to better fit the therapeutic demand. Currently, TDM is performed in centralized laboratories employing instruments, such as immunoassay analyzers and mass spectrometers that can be run only by trained personnel. However, the time required for the preparation, samples analysis, and data processing, together with the related financial cost, severely affects the application of TDM in medical practices. Therefore, a new generation of analytical tools is necessary to respond to the timely need of drug administration or reduction aiming at effectively treating oncologic patients.
Aim of the Review: State-of-the-Art Technologies for TDM: Technological advances in the field of nanosciences and biosensors offer the unique opportunity to address such issues. The interest for the so-called nanobiosensors is considerably increasing, particularly in drug discovery and clinical chemistry, even though there are only few examples reporting their use for TDM. The techniques employing nanobiosensors are mainly based on electrochemical, optical, and mass detection systems.
Conclusions: In this review, we described the most promising methodologies that, in our opinion, will bring TDM towards the next stage of clinical practice in the future.
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Cite this article as:
Biosensing Technologies for Therapeutic Drug Monitoring, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867324666170720101736
DOI https://dx.doi.org/10.2174/0929867324666170720101736 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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