摘要
地中海盆地是世界上生物多样性最丰富的地区之一,在这一地区使用药用植物治疗癌症的情况已在不同文化中被记录了好几代。目的:介绍和讨论与药用植物有关的研究结果,并提供有关活性化合物和/或明确的作用方式的确认数据。方法:利用关键词和重点复习问题,对同行评议文献书目进行结构化检索。论文有足够的质量被审查,他们的发现提出和整合到一个一致的,最先进的关于中东野生植物具有抗癌活性的文件。结果:共收录文献121篇,其中中草药10篇,世界癌症现状3篇,生物多样性、化学多样性、民族药理学调查和药用植物保护18篇,用于治疗癌症的植物天然产物12篇,中东野生植物(传统上用于治疗癌症的)特异性化合物和作用方式78篇。结论:几种传统的中药治疗癌症的野生植物存在活性化合物和(或)明确的作用模式的确认数据。然而,药用植物主要是从野外采集的,导致一些常用的草药成为濒危物种。而且,在许多情况下,在不同的时间跨度和生态系统中收获的植物的活动和生化特征可能有所不同。合理的栽培可以保证产量的优化和产品质量的统一。
关键词: 药用植物,癌症,中东,民俗,濒危物种,种植。
Current Medicinal Chemistry
Title:Review on Anti-Cancer Activity in Wild Plants of the Middle East
Volume: 25 Issue: 36
关键词: 药用植物,癌症,中东,民俗,濒危物种,种植。
摘要: Background: The Mediterranean basin is one of the richest biodiversity areas in the world, and the use of medicinal plants for treating cancer in this area has been documented for generations in different cultures.
Objective: To present and discuss the findings related to medicinal plants with confirmed data on active compounds and/or clear mode of action.
Methods: We undertook a structured search of bibliography of peer-reviewed research literature using key words and a focused review question. Papers with sufficient quality were reviewed, their findings presented and integrated into a coherent, state of the art document on wild plants of the Middle East with anti-cancer activity.
Results: 121 papers were included in the review, among them 10 define herbal medicine, 3 describe the status of cancer worldwide, 18 discuss biodiversity, chemodiversity, ethnopharmacological survey and conservation of medicinal plants, 12 describe well known natural products from plants used to treat cancer and 78 papers describe specific compounds and mode of action in different wild plants from the middle east, traditionally used to treat cancer.
Conclusions: Confirmed data on active compounds and/or clear mode of action exist for several wild plants traditionally used in herbal medicine to treat cancer. Yet, medicinal plants were mainly gathered from the wild, resulting in some of the commonly used herbs becoming endangered species. Also, in many cases, the activity and biochemical profile of plants harvested over different time spans and ecosystems may vary. Rational cultivation may ensure optimized yield with a uniform high quality of products.
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Cite this article as:
Review on Anti-Cancer Activity in Wild Plants of the Middle East, Current Medicinal Chemistry 2018; 25 (36) . https://dx.doi.org/10.2174/0929867324666170705113129
DOI https://dx.doi.org/10.2174/0929867324666170705113129 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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