Abstract
Background: For many years, anticancer polyphenols have attracted significant attention as substances that prevent tumor growth and progression. These compounds are simple phenolic acids, complex phenolic acids, such as caffeoylquinic acids, rosmarinic acid and its derivatives, stilbenes, flavones, isoflavones, and anthocyanins. Some compounds, such as tea and coffee polyphenols, can be produced in large quantities by traditional methods, while many others cannot.
Methods: We reviewed the available literature regarding the biotechnological aspects of polyphenol production by cultured plant cells and described approaches that have been used to obtain high levels of anticancer polyphenols (resveratrol, podophyllotoxin, genistein, lithospermic acid B, and others). Additionally, we provide our view on bioengineering strategies that could be important for the further improvement of cell biosynthetic characteristics.
Results: The main trend in the field is the activation of entire biosynthetic pathways based on a comprehensive knowledge of protein-protein interaction networks involved in the regulation of polyphenol biosynthesis. As an example, we consider the jasmonate subnetwork, which will be increasingly used by plant biotechnologists. The next-generation technologies to sustained polyphenol production involve manipulations with microRNAs and reproduction of rol-gene effects.
Conclusion: Plant polyphenols play an important role in maintaining human health, and their role in the prevention of cancer will continue to grow. Targeting mechanisms involved in uncontrolled cancer cell proliferation will increasingly become the standard for cancer patients. Plant biotechnological studies aiming at producing anticancer compounds will be developed in parallel with these studies to provide a wider range of metabolites for each particular case.
Keywords: Anticancer polyphenols, bioengineering strategies, biosynthesis, biotechnology, plant cell culture, secondary metabolism, systems biology.
Current Medicinal Chemistry
Title:Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies
Volume: 25 Issue: 36
Author(s): V.P. Bulgakov*, Y.V. Vereshchagina and G.N. Veremeichik
Affiliation:
- Institute of Biology and Soil Science, Far Eastern Branch of the Russian Academy of Sciences, 159 Stoletija Str., Vladivostok, 690022,Russian Federation
Keywords: Anticancer polyphenols, bioengineering strategies, biosynthesis, biotechnology, plant cell culture, secondary metabolism, systems biology.
Abstract: Background: For many years, anticancer polyphenols have attracted significant attention as substances that prevent tumor growth and progression. These compounds are simple phenolic acids, complex phenolic acids, such as caffeoylquinic acids, rosmarinic acid and its derivatives, stilbenes, flavones, isoflavones, and anthocyanins. Some compounds, such as tea and coffee polyphenols, can be produced in large quantities by traditional methods, while many others cannot.
Methods: We reviewed the available literature regarding the biotechnological aspects of polyphenol production by cultured plant cells and described approaches that have been used to obtain high levels of anticancer polyphenols (resveratrol, podophyllotoxin, genistein, lithospermic acid B, and others). Additionally, we provide our view on bioengineering strategies that could be important for the further improvement of cell biosynthetic characteristics.
Results: The main trend in the field is the activation of entire biosynthetic pathways based on a comprehensive knowledge of protein-protein interaction networks involved in the regulation of polyphenol biosynthesis. As an example, we consider the jasmonate subnetwork, which will be increasingly used by plant biotechnologists. The next-generation technologies to sustained polyphenol production involve manipulations with microRNAs and reproduction of rol-gene effects.
Conclusion: Plant polyphenols play an important role in maintaining human health, and their role in the prevention of cancer will continue to grow. Targeting mechanisms involved in uncontrolled cancer cell proliferation will increasingly become the standard for cancer patients. Plant biotechnological studies aiming at producing anticancer compounds will be developed in parallel with these studies to provide a wider range of metabolites for each particular case.
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Cite this article as:
Bulgakov V.P.*, Vereshchagina Y.V. and Veremeichik G.N., Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies, Current Medicinal Chemistry 2018; 25 (36) . https://dx.doi.org/10.2174/0929867324666170609080357
DOI https://dx.doi.org/10.2174/0929867324666170609080357 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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