摘要
背景:多年来,抗癌多酚作为预防肿瘤生长和发展的物质,受到广泛关注。这些化合物是简单的酚酸,复合酚酸,如咖啡基奎宁酸,迷迭香酸及其衍生物,二苯乙烯,黄酮,异黄酮和花青素。一些化合物,如茶和咖啡多酚,可以通过传统方法大量生产,而其他许多则不能。方法:回顾了植物培养细胞生产多酚的生物技术方面的文献,介绍了获得高水平抗癌多酚(白藜芦醇、鬼臼毒素、染料木黄酮、紫草酸B等)的方法。此外,我们还提供了我们对生物工程策略的看法,这些策略对于进一步改善细胞的生物合成特性具有重要意义。结果:基于对参与多酚生物合成调控的蛋白质-蛋白质相互作用网络的全面了解,该领域的主要趋势是激活整个生物合成途径。作为一个例子,我们考虑了茉莉酸盐子网络,它将越来越多地被植物生物技术人员使用。可持续生产多酚的下一代技术包括利用microRNAs进行操作和复制ROL基因效应。结论:植物多酚在维持人体健康方面起着重要作用,其在预防癌症中的作用将继续增强。不受控制的癌细胞增殖所涉及的靶向机制将日益成为癌症患者的标准。旨在产生抗癌化合物的植物生物技术研究将与这些研究同时进行,以便为每一特定情况提供更广泛的代谢物。
关键词: 抗癌多酚,生物工程策略,生物合成,生物技术,植物细胞培养,次生代谢,系统生物学。
Current Medicinal Chemistry
Title:Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies
Volume: 25 Issue: 36
关键词: 抗癌多酚,生物工程策略,生物合成,生物技术,植物细胞培养,次生代谢,系统生物学。
摘要: Background: For many years, anticancer polyphenols have attracted significant attention as substances that prevent tumor growth and progression. These compounds are simple phenolic acids, complex phenolic acids, such as caffeoylquinic acids, rosmarinic acid and its derivatives, stilbenes, flavones, isoflavones, and anthocyanins. Some compounds, such as tea and coffee polyphenols, can be produced in large quantities by traditional methods, while many others cannot.
Methods: We reviewed the available literature regarding the biotechnological aspects of polyphenol production by cultured plant cells and described approaches that have been used to obtain high levels of anticancer polyphenols (resveratrol, podophyllotoxin, genistein, lithospermic acid B, and others). Additionally, we provide our view on bioengineering strategies that could be important for the further improvement of cell biosynthetic characteristics.
Results: The main trend in the field is the activation of entire biosynthetic pathways based on a comprehensive knowledge of protein-protein interaction networks involved in the regulation of polyphenol biosynthesis. As an example, we consider the jasmonate subnetwork, which will be increasingly used by plant biotechnologists. The next-generation technologies to sustained polyphenol production involve manipulations with microRNAs and reproduction of rol-gene effects.
Conclusion: Plant polyphenols play an important role in maintaining human health, and their role in the prevention of cancer will continue to grow. Targeting mechanisms involved in uncontrolled cancer cell proliferation will increasingly become the standard for cancer patients. Plant biotechnological studies aiming at producing anticancer compounds will be developed in parallel with these studies to provide a wider range of metabolites for each particular case.
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Cite this article as:
Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies, Current Medicinal Chemistry 2018; 25 (36) . https://dx.doi.org/10.2174/0929867324666170609080357
DOI https://dx.doi.org/10.2174/0929867324666170609080357 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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