Title:Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents
Volume: 15
Issue: 2
Author(s): Chekuri Sharmila Rani, Meda Haritha, Mandava V. Basaveswara Rao*Manojit Pal*
Affiliation:
- Department of Chemistry, Krishna University, Machilipatnam-521001, Andhra Pradesh,India
- Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046,India
Keywords:
2-amino benzo[h]chromene, MCR, Pd/C, cytotoxicity, cytotoxic agents, potential treatment.
Abstract: Background: We report the design, synthesis and evaluation of a series of 4-biaryl
substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents.
Methods: The one-pot synthesis of this class of compounds was carried out under
ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a
key step.
Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested
against cancer cell lines but no or little effects on non-cancerous cell lines.